CAJ | 학술논문

目的观察腹腔镜和开腹结直肠癌根治术患者术后全身炎症反应综合征(SIRS)的发生,比较两种不同手术方式对患者的创伤程度.方法将85例结直肠癌患者分成开腹手术组(OP组,n=33)和腹腔镜手术组(LP组,n=52),检测术后患者SIRS发生率和持续时间,采用酶联免疫吸附法(ELISA)连续检测血清肿瘤坏死因子(TNF)-а、白细胞介素(IL)-6及IL-10水平.结果与OP组比较,LP组患者血清TNF-а和IL-6水平明显降低,IL-10水平升高,差异有统计学意义(P<0.01).LP组SIRS发生率为36.5%,低于OP组的63.6%(P<0.01),SIRS持续时间短于OP组(P<0.05).结论腹腔镜结直肠癌根治术术后患者SIRS发生率和程度较低,对机体创伤较小.
목적 관찰복강경화개복결직장암근치술환자술후전신염증반응종합정(SIRS)적발생,비교량충불동수술방식대환자적창상정도.방법 장85례결직장암환자분성개복수술조(OP조,n=33)화복강경수술조(LP조,n=52),검측술후환자SIRS발생솔화지속시간,채용매련면역흡부법(ELISA)련속검측혈청종류배사인자(TNF)-а、백세포개소(IL)-6급IL-10수평.결과 여OP조비교,LP조환자혈청TNF-а화IL-6수평명현강저,IL-10수평승고,차이유통계학의의(P<0.01).LP조SIRS발생솔위36.5%,저우OP조적63.6%(P<0.01),SIRS지속시간단우OP조(P<0.05).결론 복강경결직장암근치술술후환자SIRS발생솔화정도교저,대궤체창상교소.
Objective To compare the surgical invasiveness of laparoscopic radical resection on colorectal cancer with that of open surgery when the invasiveness is evaluated by the incidence of systemic inflammatory response syndrome (SIRS).Methods Patients with colorectal cancer who underwent open radical resection (OP group, 33 patients) and those who underwent laparoscopic radical resection (LP group,52 patients) were included in this study.We prospectly investigated the incidence and duration of SIRS in the two groups.Enzyme-linked immunoadsorbent assay (ELISA) was used to determine the serum beginning of surgery and on 1,3,5,7 day after surgery.Results No patient had any severe or life-threat-nificantly lower than those in control group (P<0.01), meanwhile, IL-10 concentration in LP group sig-nificantly higher than OP group.The incidence of SIRS in LP group was 36.5%,which was lower signifi-cantly than OP group (63.6%,P <0.01).The mean duration of SIRS was 4.8 days in the open group and 2.7 days in the laparoscopic group (P<0.05).Conclusion Laparoscopic radical resection seems less invasive than open surgery, when the magnitude of the invasiveness is evaluated by the incidence of SIRS.