CAJ | 학술논문

目的探讨白细胞介素(IL)-8多态性与食管癌发生危险因素的关系.方法采用以医院为基础的病例对照研究方法,以高分辨率熔解曲线(HRM)小片段扩增子法分析351例食管癌和384例非肿瘤对照IL-8基因多态性,计算各种基因型的食管癌发生风险及其95%可信区间.结果 IL-8-251(A/T)多态3种基因型TT、AT、AA在食管癌组和非肿瘤对照组的频率分别为39.9%(IT)、54.7%(AT)、5.4%(AA)和43.8%(TT)、45.3%(AT)、10.9%(AA),与携带IL-8-251TT基因型的个体比较,IL-8-251 AA等位基因型可以减少46%食管癌的发病风险.结论 IL-8-25l(A/T)基因多态性AA基因型可能是食管癌发生的保护性因素.
목적 탐토백세포개소(IL)-8다태성여식관암발생위험인소적관계.방법 채용이의원위기출적병례대조연구방법,이고분변솔용해곡선(HRM)소편단확증자법분석351례식관암화384례비종류대조IL-8기인다태성,계산각충기인형적식관암발생풍험급기95%가신구간.결과 IL-8-251(A/T)다태3충기인형TT、AT、AA재식관암조화비종류대조조적빈솔분별위39.9%(IT)、54.7%(AT)、5.4%(AA)화43.8%(TT)、45.3%(AT)、10.9%(AA),여휴대IL-8-251TT기인형적개체비교,IL-8-251 AA등위기인형가이감소46%식관암적발병풍험.결론 IL-8-25l(A/T)기인다태성AA기인형가능시식관암발생적보호성인소.
Objective To investigate the relationship between interleukin-8 (IL-8) polymorphism and the susceptibility to esophageal cancer in a Chinese Han population. Methods Genotypes were determined by the high resolution melting (HRM) method in 351 esophageal cancer cases and 384 controls without cancers. Results The IL-8 genotype frequency was 39. 9% ( TF), 54. 7% (AT), 5.4% (AA)in the esophageal cancer group, and 43.8% (TT), 45. 3% (AT), 10. 9% (AA) in the control group respectively. Logistic regression analyses revealed that the risk associated with IL-8 variant genotype was 0. 54 (95% CI =0. 30-0. 98) for IL-8 AA compared with its wild-type homozygote. Conclusion IL-8 AA polymorphism may serve as a protective biomarker of esophageal cancer susceptibility.