CAJ | 학술논문

目的观察纳米磁流体靶向栓塞食道曲张静脉破裂出血的止血效果及安全性.方法将10条食道静脉曲张破裂出血动物模型(犬)随机分为栓塞治疗组和对照组,治疗组经股静脉注射吸附纤维蛋白原的磁流体10 ml,食道内磁控30 min,观察出血量及止血时间,并取食道、脑组织、肝、肺、肾、心肌进行病理学检查.结果治疗组出血量(46±18)ml小于对照组(66±15)ml,差异有统计学意义(P＜0.05).治疗组止血时间(4.60±0.44)min小于对照组(5.00±0.52)min,差异有统计学意义(P＜0.05).病理学检查发现治疗组食道黏膜下静脉及穿支静脉血栓形成,脑组织、肝、肺、肾、心肌均未发现异位栓塞.结论纳米磁流体可以用于食道曲张静脉破裂出血的靶向栓塞,缩短止血时间,减少出血量,避免发生异位栓塞.
목적 관찰납미자류체파향전새식도곡장정맥파렬출혈적지혈효과급안전성.방법 장10조식도정맥곡장파렬출혈동물모형(견)수궤분위전새치료조화대조조,치료조경고정맥주사흡부섬유단백원적자류체10 ml,식도내자공30 min,관찰출혈량급지혈시간,병취식도、뇌조직、간、폐、신、심기진행병이학검사.결과 치료조출혈량(46±18)ml소우대조조(66±15)ml,차이유통계학의의(P＜0.05).치료조지혈시간(4.60±0.44)min소우대조조(5.00±0.52)min,차이유통계학의의(P＜0.05).병이학검사발현치료조식도점막하정맥급천지정맥혈전형성,뇌조직、간、폐、신、심기균미발현이위전새.결론 납미자류체가이용우식도곡장정맥파렬출혈적파향전새,축단지혈시간,감소출혈량,피면발생이위전새.
Objective To observe the hemostasis effect and safety of targeted embolization of esophagus varix hemorrhage with nano-magnetic fluid. Methods Ten canine models of esophagus varix hemorrhage were randomly divided into embolotherapy group and control group. In embolotherapy group,10 nl nano-magnetic fluid treated with fibrinogen was injected through vena femoralis and exposed to magnetic field for 10 min. Bleeding volume and hemostasis effect were recorded. Pathological changes of the esophagus, brain, liver, lung, kidney and myocardium were observed. Results Bleeding volume in embolotherapy group (46 ±18) ml was less than in control group (66±15) ml (P＜0. 05). Hemostasis time in embolotherapy group (4.60 ±0.44) min was shorter than in control group (5.00 ±0.52) min (P ＜0.05).Thromboses were found in the submucosal vein and perforating branch vein of embolotherapy group. However, no thrombosis was found in the brain, liver, lung, kidney and myocardium. Conclusion Nano-magnetic fluid can be used for targeted embolization of esophagus varix hemorrhage to promote hemostasis and avoid allotopia thrombosis.