中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
3期
552-553
,共2页
丁素春%李明川%丁永波%李爱芝%姜秀良%黄海波
丁素春%李明川%丁永波%李愛芝%薑秀良%黃海波
정소춘%리명천%정영파%리애지%강수량%황해파
氨溴索%呼吸,人工%炎症%兔
氨溴索%呼吸,人工%炎癥%兔
안추색%호흡,인공%염증%토
Ambroxol%Respiratory,artificial%Inflammation%Rabbit
目的 观察小剂量氨溴索经氧气驱动雾化吸入对家兔单肺通气(OLV)时非通气肺炎性反应的影响.方法 健康家兔40只,随机分为双肺通气组(C组)、单肺通气组(OLV组)、静脉注射氨溴索组(IA组)、氧气驱动雾化吸入氨溴索组(IAI组).C组行双肺通气2h,其余3组行右侧肺通气2h.IA组和AIA组分别在右肺通气前10 min静注氨溴索15 mg/kg或采用自制装置氧气驱动雾化吸入氨溴索7.5 mg.比较各组通气后左肺(非通气)支气管肺泡灌洗液中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-8、IL-1O浓度的变化.结果 AIA组左肺灌洗液TNF-α、IL-1β、IL-8浓度分别为(69.88±18.54)、(61.54±10.92)、(49.53±8.28) ng/L,较OLV组[(16.04±1.41)、(3.46 ±0.27)、(16.87±1.73) ng/L]明显降低；IL-1O浓度为(12.60 ±0.98) ng/L,较OLV组[(16.56±1.36) ng/L]明显升高(P＜0.01).结论 氨溴索小剂量氧气驱动雾化吸入,可有效抑制家兔OLV非通气侧肺内炎性反应.
目的 觀察小劑量氨溴索經氧氣驅動霧化吸入對傢兔單肺通氣(OLV)時非通氣肺炎性反應的影響.方法 健康傢兔40隻,隨機分為雙肺通氣組(C組)、單肺通氣組(OLV組)、靜脈註射氨溴索組(IA組)、氧氣驅動霧化吸入氨溴索組(IAI組).C組行雙肺通氣2h,其餘3組行右側肺通氣2h.IA組和AIA組分彆在右肺通氣前10 min靜註氨溴索15 mg/kg或採用自製裝置氧氣驅動霧化吸入氨溴索7.5 mg.比較各組通氣後左肺(非通氣)支氣管肺泡灌洗液中腫瘤壞死因子(TNF)-α、白細胞介素(IL)-1β、IL-8、IL-1O濃度的變化.結果 AIA組左肺灌洗液TNF-α、IL-1β、IL-8濃度分彆為(69.88±18.54)、(61.54±10.92)、(49.53±8.28) ng/L,較OLV組[(16.04±1.41)、(3.46 ±0.27)、(16.87±1.73) ng/L]明顯降低；IL-1O濃度為(12.60 ±0.98) ng/L,較OLV組[(16.56±1.36) ng/L]明顯升高(P＜0.01).結論 氨溴索小劑量氧氣驅動霧化吸入,可有效抑製傢兔OLV非通氣側肺內炎性反應.
목적 관찰소제량안추색경양기구동무화흡입대가토단폐통기(OLV)시비통기폐염성반응적영향.방법 건강가토40지,수궤분위쌍폐통기조(C조)、단폐통기조(OLV조)、정맥주사안추색조(IA조)、양기구동무화흡입안추색조(IAI조).C조행쌍폐통기2h,기여3조행우측폐통기2h.IA조화AIA조분별재우폐통기전10 min정주안추색15 mg/kg혹채용자제장치양기구동무화흡입안추색7.5 mg.비교각조통기후좌폐(비통기)지기관폐포관세액중종류배사인자(TNF)-α、백세포개소(IL)-1β、IL-8、IL-1O농도적변화.결과 AIA조좌폐관세액TNF-α、IL-1β、IL-8농도분별위(69.88±18.54)、(61.54±10.92)、(49.53±8.28) ng/L,교OLV조[(16.04±1.41)、(3.46 ±0.27)、(16.87±1.73) ng/L]명현강저；IL-1O농도위(12.60 ±0.98) ng/L,교OLV조[(16.56±1.36) ng/L]명현승고(P＜0.01).결론 안추색소제량양기구동무화흡입,가유효억제가토OLV비통기측폐내염성반응.
Objective To investigate the effects of oxygen atomizing inhalation of low dose ambroxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation (OLV).Methods Fourty healthy rabbits were randomly divided into control group (group C) receiving two-lung ventilation for two h,group OLV receiving right-lung ventilation for 2 h,group intravenous administration of ambroxol (IA) receiving intraveous injection of ambroxol 15 mg/kg,and group oxygen drive atomization inhalation of ambroxol (AIA) receiving oxygen atomizing inhalation of ambroxol 7.5 mg before right-lung ventilation for 2 h.The concentrations of tumor necrosis factor (TNF)-α,interleukin (IL)-1β,IL-8,and IL-10 in left tracheal fluid were determined.Results TNF-α,IL-1β and IL-8 concentrations in left tracheal fluid were (69.88 ± 18.54),(61.54 ± 10.92),and (49.53 ± 8.28) ng/L respectively,which were significantly increased in group AIA as compared with those in group OLV [(16.04 ± 1.41),(3.46 ± 0.27),and (16.87 ± 1.73) ng/L],while IL-10 concentration was (12.60 ± 0.98) ng/L,which was significantly higher in group AIA than in group OLV [(16.56 ± 1.36) ng/L] (P ＜ 0.01).Conclusion Oxygen atomizing inhalation of low dose ambroxol can inhibit the inflammatory response to non-ventilatied lung undergoing OLV in rabbits.
