CAJ | 학술논문

目的探讨区域灌注依据药敏实验选择的化疗药物对不能手术切除的肝癌患者的疗效.方法 120例不能手术切除的原发性肝癌患者随机分组,实验组按药敏实验选择化疗药经肝动脉/门静脉化疗泵输入,对照组经肝动脉栓塞化疗.对比两组患者的肿瘤反应率、甲胎蛋白(AFP)变化、并发症、二期手术切除率和生存时间.结果实验组肿瘤缩小或稳定分别为28、14例,对照组为17、7例.实验组AFP下降为51例而对照组为30例(P＜0.05).实验组中位随访21个月,6、12、18个月无进展生存率(PFS)及总生存期(OS)分别为:78％、70％、65％和86％、72％、65％,优于对照组(P＜0.05),实验组的化疗不良反应较对照组低(P＜0.01).结论药敏指导不能手术切除的原发性肝癌区域灌注化疗可延长生存时间并降低并发症发生率.
목적 탐토구역관주의거약민실험선택적화료약물대불능수술절제적간암환자적료효.방법 120례불능수술절제적원발성간암환자수궤분조,실험조안약민실험선택화료약경간동맥/문정맥화료빙수입,대조조경간동맥전새화료.대비량조환자적종류반응솔、갑태단백(AFP)변화、병발증、이기수술절제솔화생존시간.결과 실험조종류축소혹은정분별위28、14례,대조조위17、7례.실험조AFP하강위51례이대조조위30례(P＜0.05).실험조중위수방21개월,6、12、18개월무진전생존솔(PFS)급총생존기(OS)분별위:78％、70％、65％화86％、72％、65％,우우대조조(P＜0.05),실험조적화료불량반응교대조조저(P＜0.01).결론 약민지도불능수술절제적원발성간암구역관주화료가연장생존시간병강저병발증발생솔.
Objective To evaluate the effectiveness of sensitivity test-guided area-perfusion chemotherapy for unresectable primaryliver cancer.Methods 120 cases of human liver cancer were divided into two groups at random:experimental group and control group.Guided by the results of drug sensitivity test,3 drugs were chosen and transfused from the liver artery and portal vein pump in the experimental group.The 60 patients in the control group were subjected to transarterial chemoembolization(TACE).The tumor size,levels of alpha fetal protein (AFP),two-step operation rate,survival rate,and complications were compared between two groups.Results The tumor size measured by CT or MRI was ruduced in 28 (47.6％) cases,or stable in 14 (23.3％) cases in experimental group after six courses of chemotherapy,and 17 (28.5％) cases and7 (11.5％) cases in the control group (P＜0.05).The AFP level was declined in 51 cases of experimental group,while in 30 cases of control group (P ＜0.05).In experimental group,the median follow-up time was 21 months,the progression-free survival(PFS) and overall survival (OS) ratio at 6th,12th,and 18th month was 78％,70％,65％ and 86％,72％,and 65％ respectively,which were superior to those in control group (P ＜ 0.05).The incidence of complications in experimental group was lower than in control group (P ＜ O.01).Conclusion The artery and portal vein pump transfusion chemotherapy guided by drug Sensitivity test-guided area-perfusion chemotherapy for unresectable primary liver cancer can prelong PFS and OS,and reduce the incidence of complication.