CAJ | 학술논문

目的探讨星形细胞上调基因-1(AEG-1)和血管内皮生长因子(VEGF)在胆管癌中的表达水平及临床意义.方法用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶(SP)法检测112例胆管癌组织和29例癌旁正常组织中AEG-1和VEGF的表达水平.结果 AEG-1和VEGF在胆管癌中的表达阳性率分别为71.4％和70.5％,高于癌旁正常组织0％(P＜0.01).AEG-1在胆管癌中的表达阳性率与组织学分级(高分化45.5％、中分化64.9％、低分化86.8％)、临床分期(Ⅰ～Ⅱ期61.8％、Ⅲ～Ⅳa期91.7％)、淋巴结转移(无淋巴结转移61.8％,伴淋巴结转移91.7％)呈正相关(P＜0.05),而与患者年龄和病理类型无明显相关(P＞0.05).结论胆管癌中AEG-1和VEGF高表达提示预后较差,可作为临床评估预后的指标.
목적 탐토성형세포상조기인-1(AEG-1)화혈관내피생장인자(VEGF)재담관암중적표체수평급림상의의.방법 용면역조직화학련매균항생물소단백-과양화물매(SP)법검측112례담관암조직화29례암방정상조직중AEG-1화VEGF적표체수평.결과 AEG-1화VEGF재담관암중적표체양성솔분별위71.4％화70.5％,고우암방정상조직0％(P＜0.01).AEG-1재담관암중적표체양성솔여조직학분급(고분화45.5％、중분화64.9％、저분화86.8％)、림상분기(Ⅰ～Ⅱ기61.8％、Ⅲ～Ⅳa기91.7％)、림파결전이(무림파결전이61.8％,반림파결전이91.7％)정정상관(P＜0.05),이여환자년령화병리류형무명현상관(P＞0.05).결론 담관암중AEG-1화VEGF고표체제시예후교차,가작위림상평고예후적지표.
Objective To investigate the expression and clinical significance of astrocyte elevated gene-1 (AEG-1) and vascular endothelial growth factor (VEGF) in cholangiocarcinoma.Methods The expression levels of AEG-1 and VEGF in bile duct neoplasms were detected by using immunohistochemistry,including 112 cases of malignant tumors and 29 cases of benign tissues.Results The positive expression rate of AEG-1 and VEGF was respectively 71.4％ and 70.5％ in malignant tumors,higher than 0％ in benign tissues (P ＜0.01).The positive expression rate of AEG-1 was positively associated with histological classification (well-differentiated 45.5％,moderately differentiated 64.9％,and poorly differentiated 86.8％),clinical stage (stage Ⅰ-Ⅱ 61.8％,stage Ⅲ-Ⅳ a 91.7％) and lymph node metastasis (positive lymph node metastasis 61.8％,and negative lymph node metastasis 91.7％) (P ＜ 0.05),but not with ages and pathologic types (P ＞ 0.05).Conclusion Overexpression of AEG-1 and VEGF in cholangiocarcinoma suggests poor prognosis.They can be used as detection indexes to evaluate prognosis.