中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
4期
677-680
,共4页
顾玉翠%孙刚%马斌林%单美慧%许睿玮%周梅
顧玉翠%孫剛%馬斌林%單美慧%許睿瑋%週梅
고옥취%손강%마빈림%단미혜%허예위%주매
乳腺癌%核糖体S6蛋白激酶1%细胞质%预后
乳腺癌%覈糖體S6蛋白激酶1%細胞質%預後
유선암%핵당체S6단백격매1%세포질%예후
Infiltrating breast carcinoma%Phospho-ribosomal protein S6 kinase 1%Cytoplasmice%Prognosis
目的 探讨磷酸化核糖体S6蛋白激酶1(p-S6K1)在浸润性乳腺癌中的定位表达与临床病理特征和预后的关系.方法 对185例浸润性乳腺癌中不同亚细胞部位p-S6K1的表达及其与临床病理特征和预后的关系进行分析.结果 细胞质p-S6K1在癌和癌旁组织中的阳性表达率分别为48.1％和20.0％,差异有统计学意义(P＜0.05).细胞质p-S6K1的表达与淋巴结转移有关(P＜0.05),细胞核p-S6K1的表达与临床分期有关(P＜0.05).细胞质p-S6K1阳性表达者其无疾病生存率小于细胞质p-S6K1阴性者,差异有统计学意义(P＜0.05).临床分期、淋巴结转移和细胞质p-S6K1的表达是浸润性乳腺癌的独立预后因素(P＜0.05).结论 不同亚细胞部位p-S6K1的表达可用来标志浸润性乳腺癌不同的病理生物学特征.细胞质p-S6K1的表达是浸润性乳腺癌的一个独立的预后因素.
目的 探討燐痠化覈糖體S6蛋白激酶1(p-S6K1)在浸潤性乳腺癌中的定位錶達與臨床病理特徵和預後的關繫.方法 對185例浸潤性乳腺癌中不同亞細胞部位p-S6K1的錶達及其與臨床病理特徵和預後的關繫進行分析.結果 細胞質p-S6K1在癌和癌徬組織中的暘性錶達率分彆為48.1％和20.0％,差異有統計學意義(P＜0.05).細胞質p-S6K1的錶達與淋巴結轉移有關(P＜0.05),細胞覈p-S6K1的錶達與臨床分期有關(P＜0.05).細胞質p-S6K1暘性錶達者其無疾病生存率小于細胞質p-S6K1陰性者,差異有統計學意義(P＜0.05).臨床分期、淋巴結轉移和細胞質p-S6K1的錶達是浸潤性乳腺癌的獨立預後因素(P＜0.05).結論 不同亞細胞部位p-S6K1的錶達可用來標誌浸潤性乳腺癌不同的病理生物學特徵.細胞質p-S6K1的錶達是浸潤性乳腺癌的一箇獨立的預後因素.
목적 탐토린산화핵당체S6단백격매1(p-S6K1)재침윤성유선암중적정위표체여림상병리특정화예후적관계.방법 대185례침윤성유선암중불동아세포부위p-S6K1적표체급기여림상병리특정화예후적관계진행분석.결과 세포질p-S6K1재암화암방조직중적양성표체솔분별위48.1％화20.0％,차이유통계학의의(P＜0.05).세포질p-S6K1적표체여림파결전이유관(P＜0.05),세포핵p-S6K1적표체여림상분기유관(P＜0.05).세포질p-S6K1양성표체자기무질병생존솔소우세포질p-S6K1음성자,차이유통계학의의(P＜0.05).림상분기、림파결전이화세포질p-S6K1적표체시침윤성유선암적독립예후인소(P＜0.05).결론 불동아세포부위p-S6K1적표체가용래표지침윤성유선암불동적병리생물학특정.세포질p-S6K1적표체시침윤성유선암적일개독립적예후인소.
Objective To assess the relation of the localisation of phospho-ribosomal protein S6 kinase 1 (p-S6K1) expression with clinicopathological characteristics,as well as prognosis in infiltrating breast cancer.Methods The expression of p-S6K1 in different subcellular sites was evaluated in 185 samples of infiltrating breast cancer tissues.The relationship between the expression of different sites and the clinicopathologic variables was analyzed,as well as the prognosis of breast cancer.Results The positive expression rate of cytoplasmic p-S6K1 was 48.1％ in tumors and 20.0％ in the adjacent tissues,respectively (P ＜0.05).The expression of cytoplasmic p-S6K1 was significantly associated with lymph node metastasis (P ＜ 0.05),whereas its nuclear expression was correlated with clinical stage (P ＜ 0.05).The disease-free survival of tumors with p-S6K1 positively expressed in cytoplasm was significantly shorter than that of the tumors with negative expression (P ＜ 0.05).Clinical stage,lymph node metastasis and cytoplasmic expression of p-S6K1 were independent prognostic factors (P ＜ 0.05).Conclusion Cytoplasmic p-S6K1 expressions can be considered as indicators of different clinicopathological characteristics of tumors and may act as an independent prognostic factor of infiltrating breast cancer.
