中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
4期
684-686
,共3页
姚水宝%许红霞%陈莹蓉%沈霞萍%居星耀%吴伟平%黄惠莲%戴利成
姚水寶%許紅霞%陳瑩蓉%瀋霞萍%居星耀%吳偉平%黃惠蓮%戴利成
요수보%허홍하%진형용%침하평%거성요%오위평%황혜련%대리성
醌氧化还原酶1%基因多态性%乳腺癌%化疗
醌氧化還原酶1%基因多態性%乳腺癌%化療
곤양화환원매1%기인다태성%유선암%화료
Quinone oxidoreductase 1%Single nucleotide polymorphism%Breast carcinoma%Chemotherapeutic effect
目的 探讨醌氧化还原酶1(NQO1)基因rs1800566多态性与乳腺癌易感性及化疗敏感性的关系.方法 乳腺癌患者162名,健康对照者190例,乳腺癌患者分别接受多西紫杉醇+环磷酰胺(TC)方案和表阿霉素+5-氟尿嘧啶+环磷酰胺(FEC)方案化疗,采用TaqMan-MGB探针终点分型法检测NQO1 rs1800566位点的多态性分布,并进行统计学分析.结果 NQO1 rs1800566位点C携带患者的危险度较对照组降低[P＜0.05,比值比(OR)=0.60,95％可信区间(CI)=0.37～0.97].NQO1rs1800566位点的TT基因型是乳腺癌高危基因型(P＜0.05).NQO1 rs1800566位点C等位基因携带患者的化疗有效率为64.9％,显著高于TT基因型患者(P＜0.05).TC方案化疗患者组中,NQO1 rs1800566位点CT基因型患者的化疗有效率为71.0％,显著高于TT基因型(P＜0.05),但在FEC方案化疗组中差异无统计学意义(P＞0.05).结论 NQO1 rs1800566的基因多态性可能与乳腺癌的发生发展有一定的关系.
目的 探討醌氧化還原酶1(NQO1)基因rs1800566多態性與乳腺癌易感性及化療敏感性的關繫.方法 乳腺癌患者162名,健康對照者190例,乳腺癌患者分彆接受多西紫杉醇+環燐酰胺(TC)方案和錶阿黴素+5-氟尿嘧啶+環燐酰胺(FEC)方案化療,採用TaqMan-MGB探針終點分型法檢測NQO1 rs1800566位點的多態性分佈,併進行統計學分析.結果 NQO1 rs1800566位點C攜帶患者的危險度較對照組降低[P＜0.05,比值比(OR)=0.60,95％可信區間(CI)=0.37～0.97].NQO1rs1800566位點的TT基因型是乳腺癌高危基因型(P＜0.05).NQO1 rs1800566位點C等位基因攜帶患者的化療有效率為64.9％,顯著高于TT基因型患者(P＜0.05).TC方案化療患者組中,NQO1 rs1800566位點CT基因型患者的化療有效率為71.0％,顯著高于TT基因型(P＜0.05),但在FEC方案化療組中差異無統計學意義(P＞0.05).結論 NQO1 rs1800566的基因多態性可能與乳腺癌的髮生髮展有一定的關繫.
목적 탐토곤양화환원매1(NQO1)기인rs1800566다태성여유선암역감성급화료민감성적관계.방법 유선암환자162명,건강대조자190례,유선암환자분별접수다서자삼순+배린선알(TC)방안화표아매소+5-불뇨밀정+배린선알(FEC)방안화료,채용TaqMan-MGB탐침종점분형법검측NQO1 rs1800566위점적다태성분포,병진행통계학분석.결과 NQO1 rs1800566위점C휴대환자적위험도교대조조강저[P＜0.05,비치비(OR)=0.60,95％가신구간(CI)=0.37～0.97].NQO1rs1800566위점적TT기인형시유선암고위기인형(P＜0.05).NQO1 rs1800566위점C등위기인휴대환자적화료유효솔위64.9％,현저고우TT기인형환자(P＜0.05).TC방안화료환자조중,NQO1 rs1800566위점CT기인형환자적화료유효솔위71.0％,현저고우TT기인형(P＜0.05),단재FEC방안화료조중차이무통계학의의(P＞0.05).결론 NQO1 rs1800566적기인다태성가능여유선암적발생발전유일정적관계.
Objective To expolre the relationshio between genetic polymorphisms of quinone oxidoreductase 1 (NQO1) and susceptibility and chenosensitivity of breast cancer.Methods Totally 162 breast cancer patients and 190 non-cancer female controls were selected.The breast cancer patients were treated with TC and FEC chemotherapy.The genotypes were detected by using TaqMan-MGB probe-based real time quantitive polymerase chain reaction technology method.Results The risk of breast cancer was decreased in NQO1rs1800566 C genetic carrier [odds ratio (OR) =0.60,95％ confidence interval (CI) =0.37-0.97],compared with the controls.NQO1rs1800566 TT was the high risk genotype.The RR of C genetic carrier in NQO1rs1800566 cases was64.9％,which was significantly higher than that of the TT genotype.Among the cased administrated with TC regimens,the RR of CT genotype in NQO1rs1800566 cases was 71.0％,which was singificantly higher than that of the TT genotype.Conclusion The results indicated that the polymorphisms in NQO1 genes,which might be associated with breast cancer risk of Chinese women.
