中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
4期
842-844
,共3页
维吾尔族%汉族%帕金森病%ATP13A2基因%多态性
維吾爾族%漢族%帕金森病%ATP13A2基因%多態性
유오이족%한족%파금삼병%ATP13A2기인%다태성
Uygur nationality%Han nationality%Parkinson' s disease%ATP13A2 genes%Polymorphism
目的 探讨ATP13A2基因丙氨酸(Ala)746苏氨酸(Thr)多态性在新疆维吾尔族和汉族人群中的分布及与帕金森病(PD)的关系.方法 采用病例-对照研究,以聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)对429例PD患者及年龄、性别、民族相匹配的健康对照组390例进行ATP13A2基因Ma746Thr多态性分析.结果 新疆维吾尔族和汉族PD组与正常对照组间ATP13A2基因Ala746Thr基因型及等位基因频率,差异无统计学意义(基因型x2 =0.91,P＞0.05;等位基因x2 =0.91,P＞0.05).分层分析中,PD组与正常对照组中年龄、性别与种族亚组间ATP13A2基因Ala746Thr基因型及等位基因频率,差异均无统计学意义(P＞0.05).结论 ATP13A2基因Ala746Thr多态性与新疆维吾尔族和汉族PD的发生可能无相关性.
目的 探討ATP13A2基因丙氨痠(Ala)746囌氨痠(Thr)多態性在新疆維吾爾族和漢族人群中的分佈及與帕金森病(PD)的關繫.方法 採用病例-對照研究,以聚閤酶鏈反應-限製性片段長度多態性方法(PCR-RFLP)對429例PD患者及年齡、性彆、民族相匹配的健康對照組390例進行ATP13A2基因Ma746Thr多態性分析.結果 新疆維吾爾族和漢族PD組與正常對照組間ATP13A2基因Ala746Thr基因型及等位基因頻率,差異無統計學意義(基因型x2 =0.91,P＞0.05;等位基因x2 =0.91,P＞0.05).分層分析中,PD組與正常對照組中年齡、性彆與種族亞組間ATP13A2基因Ala746Thr基因型及等位基因頻率,差異均無統計學意義(P＞0.05).結論 ATP13A2基因Ala746Thr多態性與新疆維吾爾族和漢族PD的髮生可能無相關性.
목적 탐토ATP13A2기인병안산(Ala)746소안산(Thr)다태성재신강유오이족화한족인군중적분포급여파금삼병(PD)적관계.방법 채용병례-대조연구,이취합매련반응-한제성편단장도다태성방법(PCR-RFLP)대429례PD환자급년령、성별、민족상필배적건강대조조390례진행ATP13A2기인Ma746Thr다태성분석.결과 신강유오이족화한족PD조여정상대조조간ATP13A2기인Ala746Thr기인형급등위기인빈솔,차이무통계학의의(기인형x2 =0.91,P＞0.05;등위기인x2 =0.91,P＞0.05).분층분석중,PD조여정상대조조중년령、성별여충족아조간ATP13A2기인Ala746Thr기인형급등위기인빈솔,차이균무통계학의의(P＞0.05).결론 ATP13A2기인Ala746Thr다태성여신강유오이족화한족PD적발생가능무상관성.
Objective To explore the distribution of Ala746Thr ATP13A2 gene polymorphism in Xinjiang Uygur and Han People,and its association with Parkinson' s disease (PD).Methods A casecontrol study with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed on 439 cases of PD and 390 age-,sex-and national-matched healthy controls for ATP13A2 gene polymorphism analysis.Results The frequencies of Ala746Thr genotype and allele between PD and control groups in Uygur and Han people showed no significant difference (for genotype,x2 =0.91,P ＞ 0.05 ; for allele,x2 =0.91,P ＞ 0.05).Sratified analysis showed that no differences in allele and genotype frequencies of Ala746Thr genotype between PD and control groups among the age,gender or race (P ＞0.05).Conclusion The polymorphism of ATP13A2 gene Ala746Thr may have nothing to do with the occurrence of PD in Uygur and Han people of Xinjiang.
