CAJ | 학술논문

目的观察梗阻性无精症患者采用附睾精子或睾丸精子行卵胞质内单精子注射(ICSI)助孕后胚胎发育、妊娠结局及子代安全性差异.方法梗阻性无精症患者ICSI治疗395个周期,分经皮附睾穿刺取精(PESA)组和经皮睾丸穿刺取精(TESA)组,记录和分析两组胚胎发育和妊娠结局指标.结果 PESA组正常受精率(73.02％比68.82％)、卵裂率(98.73％比97.27％)高于TESA组(P＜0.05)；两组优胚率、种植率、临床妊娠率、流产率及新生儿出生缺陷比较,差异均无统计学意义(P＞0.05).结论 PESA或TESA取精行ICSI患者妊娠结局及子代安全性差异无统计学意义,临床上可视具体情况选择取精方式.
목적 관찰경조성무정증환자채용부고정자혹고환정자행란포질내단정자주사(ICSI)조잉후배태발육、임신결국급자대안전성차이.방법 경조성무정증환자ICSI치료395개주기,분경피부고천자취정(PESA)조화경피고환천자취정(TESA)조,기록화분석량조배태발육화임신결국지표.결과 PESA조정상수정솔(73.02％비68.82％)、란렬솔(98.73％비97.27％)고우TESA조(P＜0.05)；량조우배솔、충식솔、림상임신솔、유산솔급신생인출생결함비교,차이균무통계학의의(P＞0.05).결론 PESA혹TESA취정행ICSI환자임신결국급자대안전성차이무통계학의의,림상상가시구체정황선택취정방식.
Objective To analyze the difference of embryonic development,pregnancy outcomes and safety of the offspring between percutaneous epididymal sperm aspiration-introcytoplasmic sperm injection (PESA-ICSI) and testicular sperm aspiration (TESA-ICSI).Methods The embryonic development and clinical outcomes in both groups of PESA-ICSI and TESA-ICSI were recorded and retrospectively analyzed.Results Both the normal fertilization rate and normal cleavage rate of the PESA group were significantly higher than in the TESA group (P ＜ 0.05).In contrast,no significant difference was detected in high-quality embryo rate,implantation rate,clinical pregnancy,miscarriage rate and birth defects between these two groups (P ＞ 0.05).Conclusion There was no significant difference in pregnancy outcomes and safety of the offspring between PESA-ICSI and TESA-ICSI.