中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
5期
1065-1066
,共2页
骨性关节炎%骨化三醇%疗效
骨性關節炎%骨化三醇%療效
골성관절염%골화삼순%료효
Osteoarthritis%Rocalirol%Treatment effect
目的 观察骨化三醇对原发性骨性关节炎的治疗效果.方法 收集2011年10月至2012年10月在海口市人民医院骨化三醇治疗的膝关节骨性关节炎的患者30例,测定并分析血1,25-二羟基维生素D3(1,25-(OH)2D3)与24 h的尿钙、磷水平.对治疗前与治疗后的数据采用单因素方差分析及相关性检测评估其疗效.结果 1年内30例患者按时回院检查,随访率为100％.与治疗前比较,治疗半月至1年病患的膝关节疼痛均有不同程度的好转:西安大略和曼彻斯特大学骨关节炎指数(WOMAC)可视量化,骨关节炎指数显著降低(治疗前为7.2±1.5,1年后为2.6±1.0,P＜0.05),腰椎骨密度增高[治疗前为(0.70 ±0.04) g/cm2,1年后为(0.83 ±0.07) g/cm2,P＜0.05],血浆1,25-(OH)2D3水平显著增高[治疗前为(35.6±18.2) nmol/L,1年后(50.3±11.2) nmol/L,P＜0.05],24h尿钙、磷水平显著降低[治疗前尿钙为(4.98±0.67) nmol/L,尿磷为(32.6±7.2)nmol/L;1年后尿钙为(2.84 ±0.57) nmol/L,尿磷为(20.9±6.5)nmol/L,P＜0.05].结论 骨化三醇通过抑制骨质流失,达到缓解疼痛和恢复关节功能.
目的 觀察骨化三醇對原髮性骨性關節炎的治療效果.方法 收集2011年10月至2012年10月在海口市人民醫院骨化三醇治療的膝關節骨性關節炎的患者30例,測定併分析血1,25-二羥基維生素D3(1,25-(OH)2D3)與24 h的尿鈣、燐水平.對治療前與治療後的數據採用單因素方差分析及相關性檢測評估其療效.結果 1年內30例患者按時迴院檢查,隨訪率為100％.與治療前比較,治療半月至1年病患的膝關節疼痛均有不同程度的好轉:西安大略和曼徹斯特大學骨關節炎指數(WOMAC)可視量化,骨關節炎指數顯著降低(治療前為7.2±1.5,1年後為2.6±1.0,P＜0.05),腰椎骨密度增高[治療前為(0.70 ±0.04) g/cm2,1年後為(0.83 ±0.07) g/cm2,P＜0.05],血漿1,25-(OH)2D3水平顯著增高[治療前為(35.6±18.2) nmol/L,1年後(50.3±11.2) nmol/L,P＜0.05],24h尿鈣、燐水平顯著降低[治療前尿鈣為(4.98±0.67) nmol/L,尿燐為(32.6±7.2)nmol/L;1年後尿鈣為(2.84 ±0.57) nmol/L,尿燐為(20.9±6.5)nmol/L,P＜0.05].結論 骨化三醇通過抑製骨質流失,達到緩解疼痛和恢複關節功能.
목적 관찰골화삼순대원발성골성관절염적치료효과.방법 수집2011년10월지2012년10월재해구시인민의원골화삼순치료적슬관절골성관절염적환자30례,측정병분석혈1,25-이간기유생소D3(1,25-(OH)2D3)여24 h적뇨개、린수평.대치료전여치료후적수거채용단인소방차분석급상관성검측평고기료효.결과 1년내30례환자안시회원검사,수방솔위100％.여치료전비교,치료반월지1년병환적슬관절동통균유불동정도적호전:서안대략화만철사특대학골관절염지수(WOMAC)가시양화,골관절염지수현저강저(치료전위7.2±1.5,1년후위2.6±1.0,P＜0.05),요추골밀도증고[치료전위(0.70 ±0.04) g/cm2,1년후위(0.83 ±0.07) g/cm2,P＜0.05],혈장1,25-(OH)2D3수평현저증고[치료전위(35.6±18.2) nmol/L,1년후(50.3±11.2) nmol/L,P＜0.05],24h뇨개、린수평현저강저[치료전뇨개위(4.98±0.67) nmol/L,뇨린위(32.6±7.2)nmol/L;1년후뇨개위(2.84 ±0.57) nmol/L,뇨린위(20.9±6.5)nmol/L,P＜0.05].결론 골화삼순통과억제골질류실,체도완해동통화회복관절공능.
Objective To examine the curative effects of calcitril in the treatment of primary osteoarthritis.Methods From October 2011 to October 2012,30 cases of osteoarthritis in our hospital were collected and studied.Blood 1,25-two hydroxy vitamin D 3 [1,25-(OH)2D3],and urinary calcium and phosphorus in 24 h were measured.Results During one year,30 cases came back for check-up.As compared with before treatment,patients had different degrees of recovery after treatment for 6 months and one year:western Ontario and McMaster universities osteoarthritis index (WOMAC) was significantly reduced (20.9 ± 6.5 and 2.6 ± 1.0 before and one year after treatment respectively,P ＜ 0.05),lumbar spine BMD increased significantly [(0.70 ± 0.04) g/cm2 and (0.83 ± 0.07) g/cm2 before and one year after treatment respectively,P ＜ 0.05],plasma 1,25-(OH),2D3 levels significantly increased [(35.6 ± 18.2) nmol/L and (50.3 ± 11.2) nmol/L before and one year after treatment respectively,P ＜ 0.05],and 24 h urinary calcium and phosphorus levels significantly reduced [for urinary calcium and phosphorus levels,(4.98 ±0.67) nmol/L and (32.6 ±7.2) nmol/L,and (2.84 ±0.57) nmol/L and (20.9 ±6.5) nmol/L before and one year after treatment respectively,P ＜ 0.05].Conclusion Calcitriol can inhibit bone loss,relieve pain and restore joint function.
