中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
6期
1266-1267
,共2页
神经母细胞瘤%cdc25B%N-myc%原癌基因%基因表达
神經母細胞瘤%cdc25B%N-myc%原癌基因%基因錶達
신경모세포류%cdc25B%N-myc%원암기인%기인표체
Neuroblastoma%cdc25B%N-myc%Proto-oncogene%Gene expression
目的 探讨儿童神经母细胞瘤患者cdc25B mRNA与原癌基因N-myc表达水平相关性.方法 通过使用实时定量聚合酶链反应(Real-time PCR)观察15例神经母细胞瘤患者肿瘤细胞cdc25B和N-myc mRNA表达水平,探讨患者临床表征.结果 cdc25B的表达水平在不同临床分期患者之间差异无统计学意义(P＞0.05)；cdc25B和N-myc mRNA表达水平间呈正相关(P＜0.01)；cdc25B表达量不同两组患者中的存活率差异无统计学意义(P＞0.05).结论 cdc25B的表达水平与患者的年龄、性别、临床分期无明显相关,但和N-myc的mRNA表达水平明显相关.
目的 探討兒童神經母細胞瘤患者cdc25B mRNA與原癌基因N-myc錶達水平相關性.方法 通過使用實時定量聚閤酶鏈反應(Real-time PCR)觀察15例神經母細胞瘤患者腫瘤細胞cdc25B和N-myc mRNA錶達水平,探討患者臨床錶徵.結果 cdc25B的錶達水平在不同臨床分期患者之間差異無統計學意義(P＞0.05)；cdc25B和N-myc mRNA錶達水平間呈正相關(P＜0.01)；cdc25B錶達量不同兩組患者中的存活率差異無統計學意義(P＞0.05).結論 cdc25B的錶達水平與患者的年齡、性彆、臨床分期無明顯相關,但和N-myc的mRNA錶達水平明顯相關.
목적 탐토인동신경모세포류환자cdc25B mRNA여원암기인N-myc표체수평상관성.방법 통과사용실시정량취합매련반응(Real-time PCR)관찰15례신경모세포류환자종류세포cdc25B화N-myc mRNA표체수평,탐토환자림상표정.결과 cdc25B적표체수평재불동림상분기환자지간차이무통계학의의(P＞0.05)；cdc25B화N-myc mRNA표체수평간정정상관(P＜0.01)；cdc25B표체량불동량조환자중적존활솔차이무통계학의의(P＞0.05).결론 cdc25B적표체수평여환자적년령、성별、림상분기무명현상관,단화N-myc적mRNA표체수평명현상관.
Objective To study the correlation between cdc25B mRNA expression and N-myc expression in children with neuroblastoma.Methods The expression of cdc25B and N-myc mRNA was detected by using RT-PCR in 15 children with neuroblastima,and its correlation with clinicopathological features was analyzed.Results There was no significant difference in the cdc25B expression among different clinical stages in neuroblastima.The cdc25B mRNA expression levels waere significantly correlated with N-myc mRNA levels (P ＜ 0.005).Conclusion The cdc25 B mRNA expression level was not correlated with age,gender and clinical stage of children with neuroblastima,significantly with the N-myc expression level.
