CAJ | 학술논문

目的观察吡格列酮(Pio)在心脏移植排斥反应中的作用,探讨Pio减轻心脏移植排斥反应的机制.方法建立大鼠腹部心脏移植模型,分组给予全量环孢素A(CsA)5 mg/kg、半量CsA、Pio,以及Pio与不同剂量的CsA联合应用,术后3、7、14、28 d观察移植心脏存活时间、病理变化、脾脏CD25+、CD28+T细胞的表达以及血清白细胞介素(IL)-2的变化.结果 Pio与CsA联合应用能够明显延长移植心脏的存活时间,减轻心脏的排斥反应,降低脾脏CD25+、CD28+的表达,降低血清IL-2的浓度(P＜0.05).结论 Pio与CsA联合应用可减少CsA的用量,减轻排斥反应,改善受体的生存状态.
목적 관찰필격렬동(Pio)재심장이식배척반응중적작용,탐토Pio감경심장이식배척반응적궤제.방법 건립대서복부심장이식모형,분조급여전량배포소A(CsA)5 mg/kg、반량CsA、Pio,이급Pio여불동제량적CsA연합응용,술후3、7、14、28 d관찰이식심장존활시간、병리변화、비장CD25+、CD28+T세포적표체이급혈청백세포개소(IL)-2적변화.결과 Pio여CsA연합응용능구명현연장이식심장적존활시간,감경심장적배척반응,강저비장CD25+、CD28+적표체,강저혈청IL-2적농도(P＜0.05).결론 Pio여CsA연합응용가감소CsA적용량,감경배척반응,개선수체적생존상태.
Objective To study the role of pioglitazone (Pio) in heart transplantation rejection and the mechanism.Methods In the rat heart transplantation model,pio was combined with cyclosporin A (CsA) in different doses as the experimental group,and CsA was used alone in different doses as the control group.On the post-transplantation day 3,7,14 and 28,the survival,patholgogical changes,expression of splenic CD25 + and CD28 + T cells and serum interleukin (IL)-2 were observed.Results The combined use of Pio and CsA could significantly prologn the survival of the donor hearts,alleviated rejection of the transplanted hearts,reduced the expression of splenic CD25 + and CD28 + T cells,and decreased the levels of serum IL-2 (P ＜ 0.05).Conclusion The combined use of Pio and CsA could reduce the usage of CsA,alleviate rejection and impromve the survival state of the recipients.