中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
8期
1723-1725
,共3页
胃癌%疼痛%SCN9A%单核苷酸多态性
胃癌%疼痛%SCN9A%單覈苷痠多態性
위암%동통%SCN9A%단핵감산다태성
Gastric carcinoma%Pain%SCN9A%Single nucleotide polymorphism
目的 SCN9A基因单核苷酸多态性(SNPs)对胃癌手术术后患者疼痛敏感性的影响,寻找干预术后疼痛的靶点.方法 选取胃癌手术患者232例,术前进行疼痛阈值以及疼痛耐受力检测,术后进行疼痛敏感性检测并记录术后镇痛药的使用剂量.对每位患者的SCN9A基因进行SNPs检测(3312G＞T).比较SCN9A 3312G＞T和术后疼痛敏感性以及术后镇痛药使用剂量之间的关系.结果 SCN9A 3312 T的等位基因的患者有28例(12.1％),3312G的患者为204例(87.9％)；术后镇痛药的给药频率[(2.78±0.75)比(2.01±0.63)小时/次,P＜0.0S]和给药量[(105.3±21.6)比(69.8±17.3) ml,P＜0.05]在3312G的患者明显高于3312T的患者；3312G组患者发生镇痛不良的概率高于3312T的患者(29.4％比8.6％,P＜0.05)；回归相关分析表明SCN9A在3312位的基因改变以及疼痛阈值高与术后疼痛的敏感性有较强相关性[比值比(OR) =0.12；OR=0.29].结论 SCN9A 3312G ＞T可以降低大型手术术后患者的疼痛敏感性.
目的 SCN9A基因單覈苷痠多態性(SNPs)對胃癌手術術後患者疼痛敏感性的影響,尋找榦預術後疼痛的靶點.方法 選取胃癌手術患者232例,術前進行疼痛閾值以及疼痛耐受力檢測,術後進行疼痛敏感性檢測併記錄術後鎮痛藥的使用劑量.對每位患者的SCN9A基因進行SNPs檢測(3312G＞T).比較SCN9A 3312G＞T和術後疼痛敏感性以及術後鎮痛藥使用劑量之間的關繫.結果 SCN9A 3312 T的等位基因的患者有28例(12.1％),3312G的患者為204例(87.9％)；術後鎮痛藥的給藥頻率[(2.78±0.75)比(2.01±0.63)小時/次,P＜0.0S]和給藥量[(105.3±21.6)比(69.8±17.3) ml,P＜0.05]在3312G的患者明顯高于3312T的患者；3312G組患者髮生鎮痛不良的概率高于3312T的患者(29.4％比8.6％,P＜0.05)；迴歸相關分析錶明SCN9A在3312位的基因改變以及疼痛閾值高與術後疼痛的敏感性有較彊相關性[比值比(OR) =0.12；OR=0.29].結論 SCN9A 3312G ＞T可以降低大型手術術後患者的疼痛敏感性.
목적 SCN9A기인단핵감산다태성(SNPs)대위암수술술후환자동통민감성적영향,심조간예술후동통적파점.방법 선취위암수술환자232례,술전진행동통역치이급동통내수력검측,술후진행동통민감성검측병기록술후진통약적사용제량.대매위환자적SCN9A기인진행SNPs검측(3312G＞T).비교SCN9A 3312G＞T화술후동통민감성이급술후진통약사용제량지간적관계.결과 SCN9A 3312 T적등위기인적환자유28례(12.1％),3312G적환자위204례(87.9％)；술후진통약적급약빈솔[(2.78±0.75)비(2.01±0.63)소시/차,P＜0.0S]화급약량[(105.3±21.6)비(69.8±17.3) ml,P＜0.05]재3312G적환자명현고우3312T적환자；3312G조환자발생진통불량적개솔고우3312T적환자(29.4％비8.6％,P＜0.05)；회귀상관분석표명SCN9A재3312위적기인개변이급동통역치고여술후동통적민감성유교강상관성[비치비(OR) =0.12；OR=0.29].결론 SCN9A 3312G ＞T가이강저대형수술술후환자적동통민감성.
Objective To explore the role of SCN9A single nucleotide polymorphism (SNPs) in postoperative pain of gastrectomy patients and define a new target for analgesia.Methods 232 gastric cancer patients who were subjected to gastrectomy were included in this study.SCN9A 3312G ＞ T alleles in each patient were detected by genetic analysis.The preoperative pressure pain thresholds and tolerance were measured before the operation,and the incidence of inadequate analgesia and average patient-controlled analgesia pressing frequency and opioid consumption were recorded after operation.These variables were compared according to the SCN9A SNPs.The role of preoperative variables in postoperative inadequate analgesia was predicted by Logistic regression analysis.Results The ratio of SCN9A 3312G ＞ T was 12.1％ (28 cases of SCN9A 3312T and rest of SCN9A 3312G).The incidence of inadequate analgesia was higher in 3312G group than in 3312T group (29.4％ vs.8.6％,P ＜0.05).The average patient-controlled analgesia pressing frequency and opioid consumption were also increased in 3312G group as compared with 3312T group [(2.78 ±0.75) vs.(2.01 ±0.63) h/time; (105.3 ±21.6) vs.(69.8 ± 17.3) ml,P ＜0.05].SCN9A 3312G ＞ T alleles and higher pressure pain threshold predicted a lower risk of postoperative inadequate analgesia (with an odds ratio of 0.12 and 0.29 respectively).Conclusion SCN9A SNPs (3312G ＞ T alleles) was related to postoperative pain in gastrectomy patients.
