CAJ | 학술논문

目的探讨术前外周血中性粒细胞与淋巴细胞比值(NLR)与胃癌各种临床病理指标的关系.方法分析201例胃癌患者术前NLR与肿瘤浸润深度、病理组织学特征、淋巴结转移及复发等各种临床病理指标的关系.结果胃癌术前的NLR与肿瘤浸润深度(x2=6.147,P＜0.05)、淋巴结转移(x2=28.297,P＜0.01)、术前血清癌胚抗原(CEA)水平(2=25.722,P＜0.01)、复发(x2=43.620,P ＜0.01)呈正相关,与肿瘤的组织学类型无明显相关.Kaplan-Meier生存分析表明NLR升高的胃癌患者生存时间为(28.448±3.395)个月,NLR正常组生存时间为(65.802±2.982)个月,预后明显差于NLR值低者(x2=54.585,P＜0.01).结论 NLR可能是胃癌预后的重要指标,NLR是胃癌淋巴结转移及术后复发的指标之一.
목적 탐토술전외주혈중성립세포여림파세포비치(NLR)여위암각충림상병리지표적관계.방법 분석201례위암환자술전NLR여종류침윤심도、병리조직학특정、림파결전이급복발등각충림상병리지표적관계.결과 위암술전적NLR여종류침윤심도(x2=6.147,P＜0.05)、림파결전이(x2=28.297,P＜0.01)、술전혈청암배항원(CEA)수평(2=25.722,P＜0.01)、복발(x2=43.620,P ＜0.01)정정상관,여종류적조직학류형무명현상관.Kaplan-Meier생존분석표명NLR승고적위암환자생존시간위(28.448±3.395)개월,NLR정상조생존시간위(65.802±2.982)개월,예후명현차우NLR치저자(x2=54.585,P＜0.01).결론 NLR가능시위암예후적중요지표,NLR시위암림파결전이급술후복발적지표지일.
Objective To find out the relationship between periferal blood neutrophil to lympnocyte ratio and various clinicopathological factors in patients with gastric cancer.Methods A total of 201 patients with gastric cancer,who underwent curative resection in our hospital,were included.A total of 65 patients with neutrophil to lymphocyte ratio (NLR) of 2.9 or more were classified as high NLR individuals,while the NLR of other patients was under 2.9 in this study.Various clinicopathological factors including depth of invasion,pathological and histological characteristics,lymph node metastasis and tumor recurrence were analyzed retrospectively.Results Chis-Square test showed that the preoperative NLR was positively correlated with the depth of invasion,lymph node metastasis,recurrence and preoperative serum-carcinoembryonic antigen(CEA) level,but not with the pathological and histological characteristics (P ＞ 0.05).Multivariate logistic regression analysis revealed that the lymph node metastasis,postoperative recurrence and preoperative serum-CEA level were the relevant factor of value of NLR among all the clinicopathologic variables.The Kaplan-Meier methodology indicated the prognosis of patients with a high NLR was significantly worse than that of patients with a low NLR (x2 =54.585,P ＜ 0.01).Conclusion The NLR is one of independent prognostic indicator,and it is one of independent factors as lymph node metastasis and postoperative recurrence in gastric cancer patients.