中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
8期
1758-1760
,共3页
前列腺增生%雄激素受体%蛋白B淋巴细胞/白血病-xL%衰老逃逸
前列腺增生%雄激素受體%蛋白B淋巴細胞/白血病-xL%衰老逃逸
전렬선증생%웅격소수체%단백B림파세포/백혈병-xL%쇠로도일
Benign prostatic hyperplasia%Androgen receptor%B lymphocytes/leukemia-xL%Aging escape
目的 探讨抗凋亡蛋白B淋巴细胞/白血病-xL (bcl-xL)在良性前列腺增生(BPH)发病机制中的作用及其与临床指标的关系.方法 采用免疫组织化学法检测bcl-xL和雄激素受体(AR)在30例BPH和16例正常前列腺标本(正常对照组)中的表达；用等级相关分析方法分析bcl-xL与临床数据的关系.结果 bcl-xL和AR在BPH组中的表达分别为7.982±2.542和9.837±3.493,在正常对照组的表达分别为3.991±0.508和7.328±0.612,BPH组的表达量明显高于正常对照组(P＜0.05)；在BPH组30例患者中bcl-xL与AR的表达采用Spearman等级相关系数分析结果(r =0.540,P＜0.01),两者呈正相关(P＜0.05)；此外,bcl-xL的表达与BPH患者的年龄、前列腺体积及前列腺特异抗原(PSA)值相关系数分别为0.712、0.684和0.379,均呈正相关(P＜0.05).结论 bcl-xL在良性前列腺增生衰老逃逸发病机制中可能具有重要作用,并且与BPH的进展明显相关.
目的 探討抗凋亡蛋白B淋巴細胞/白血病-xL (bcl-xL)在良性前列腺增生(BPH)髮病機製中的作用及其與臨床指標的關繫.方法 採用免疫組織化學法檢測bcl-xL和雄激素受體(AR)在30例BPH和16例正常前列腺標本(正常對照組)中的錶達；用等級相關分析方法分析bcl-xL與臨床數據的關繫.結果 bcl-xL和AR在BPH組中的錶達分彆為7.982±2.542和9.837±3.493,在正常對照組的錶達分彆為3.991±0.508和7.328±0.612,BPH組的錶達量明顯高于正常對照組(P＜0.05)；在BPH組30例患者中bcl-xL與AR的錶達採用Spearman等級相關繫數分析結果(r =0.540,P＜0.01),兩者呈正相關(P＜0.05)；此外,bcl-xL的錶達與BPH患者的年齡、前列腺體積及前列腺特異抗原(PSA)值相關繫數分彆為0.712、0.684和0.379,均呈正相關(P＜0.05).結論 bcl-xL在良性前列腺增生衰老逃逸髮病機製中可能具有重要作用,併且與BPH的進展明顯相關.
목적 탐토항조망단백B림파세포/백혈병-xL (bcl-xL)재량성전렬선증생(BPH)발병궤제중적작용급기여림상지표적관계.방법 채용면역조직화학법검측bcl-xL화웅격소수체(AR)재30례BPH화16례정상전렬선표본(정상대조조)중적표체；용등급상관분석방법분석bcl-xL여림상수거적관계.결과 bcl-xL화AR재BPH조중적표체분별위7.982±2.542화9.837±3.493,재정상대조조적표체분별위3.991±0.508화7.328±0.612,BPH조적표체량명현고우정상대조조(P＜0.05)；재BPH조30례환자중bcl-xL여AR적표체채용Spearman등급상관계수분석결과(r =0.540,P＜0.01),량자정정상관(P＜0.05)；차외,bcl-xL적표체여BPH환자적년령、전렬선체적급전렬선특이항원(PSA)치상관계수분별위0.712、0.684화0.379,균정정상관(P＜0.05).결론 bcl-xL재량성전렬선증생쇠로도일발병궤제중가능구유중요작용,병차여BPH적진전명현상관.
Objective To study the effects of antiapoptotic protein B lymphocytes/leukemia-xL (bcl-xL) on benign prostatic hyperplasia (BPH) pathogenesis and their relationship to the clinical indicators.Methods The expression of bcl-xL and androgen receptor (AR) in 30 BPH tissues and 16 normal prostatic tissues was detected by using immunohistochemistry.The relationship between bcl-xL and clinical indicators was analyzed by Spearman correlation test.Results As compared with normal prostatic tissues (3.991 ± 0.508 and 7.328 ± 0.612),the expression of bcl-xL and AR was significantly increased in BPH tissues (7.982 ± 2.542 and 9.837 ± 3.493,P ＜ 0.05),and there was a positive correlation (0.540,P ＜ 0.01) between the expression of bcl-xL and AR in BPH.In addition,the expression of bcl-xL had a positive correlation with patients' age,prostate volume and PSA with the correlation coefficient being 0.712,0.684 and 0.379 respectivcly(P ＜ 0.05).Conclusion bcl-xL may play an important role in aging escape mechanism of BPH and have certain relevance with the progress of BPH.
