中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
9期
1819-1820
,共2页
高建国%陈锋龙%翁名相%龙建武%刁艺%叶惠龙
高建國%陳鋒龍%翁名相%龍建武%刁藝%葉惠龍
고건국%진봉룡%옹명상%룡건무%조예%협혜룡
神经胶质瘤%出核因子%表皮生长因子受体
神經膠質瘤%齣覈因子%錶皮生長因子受體
신경효질류%출핵인자%표피생장인자수체
Glioma%Chromosome region maintenance 1%Epidermal growth factor receptor
目的 探讨出核因子(CRM1)和表皮生长因子受体(EGFR)在胶质瘤中的表达及相关性.方法 免疫组织化学链霉菌抗生物素蛋白-过氧化物酶(SP)法检测75例胶质瘤标本中CRM1和EGFR表达,并分析两蛋白间的相关性.结果 Ⅰ～Ⅳ级胶质瘤中CRM1阳性率分别为25.00％ (2/8)、58.33％ (14/24)、80.77％ (21/26)及94.12％(16/17) (x2=15.6,P＜0.05);EGFR阳性率分别为25.00％(2/8)、54.17％ (13/24)、69.23％ (18/26)及88.23％(15/17)(x2=10.70,P＜0.05).CRM1和EGFR共阳性表达40例,EGFR和CRM1共阴性表达14例,EGFR阳性而CRM1阴性表达8例,EGFR阴性而CRM1阳性表达13例(r=0.371,P＜0.05).结论 EGFR和CRM1在胶质瘤中表达呈正相关,有助于判断患者预后.
目的 探討齣覈因子(CRM1)和錶皮生長因子受體(EGFR)在膠質瘤中的錶達及相關性.方法 免疫組織化學鏈黴菌抗生物素蛋白-過氧化物酶(SP)法檢測75例膠質瘤標本中CRM1和EGFR錶達,併分析兩蛋白間的相關性.結果 Ⅰ～Ⅳ級膠質瘤中CRM1暘性率分彆為25.00％ (2/8)、58.33％ (14/24)、80.77％ (21/26)及94.12％(16/17) (x2=15.6,P＜0.05);EGFR暘性率分彆為25.00％(2/8)、54.17％ (13/24)、69.23％ (18/26)及88.23％(15/17)(x2=10.70,P＜0.05).CRM1和EGFR共暘性錶達40例,EGFR和CRM1共陰性錶達14例,EGFR暘性而CRM1陰性錶達8例,EGFR陰性而CRM1暘性錶達13例(r=0.371,P＜0.05).結論 EGFR和CRM1在膠質瘤中錶達呈正相關,有助于判斷患者預後.
목적 탐토출핵인자(CRM1)화표피생장인자수체(EGFR)재효질류중적표체급상관성.방법 면역조직화학련매균항생물소단백-과양화물매(SP)법검측75례효질류표본중CRM1화EGFR표체,병분석량단백간적상관성.결과 Ⅰ～Ⅳ급효질류중CRM1양성솔분별위25.00％ (2/8)、58.33％ (14/24)、80.77％ (21/26)급94.12％(16/17) (x2=15.6,P＜0.05);EGFR양성솔분별위25.00％(2/8)、54.17％ (13/24)、69.23％ (18/26)급88.23％(15/17)(x2=10.70,P＜0.05).CRM1화EGFR공양성표체40례,EGFR화CRM1공음성표체14례,EGFR양성이CRM1음성표체8례,EGFR음성이CRM1양성표체13례(r=0.371,P＜0.05).결론 EGFR화CRM1재효질류중표체정정상관,유조우판단환자예후.
Objective To investigate the expression and correlation of chromosome region maintenance 1 (CRM1) and epidermal growth factor receptor (EGFR) in glioma.Methods The expression and correlation of CRM1 and EGFR in 75 glioma specimens were analyzed by using immunohistochemical technique,and the correlation analysis between the two different proteins was performed by statistical method.Results Ratio of CRM1 expression was 25.00％ (2/8),58.33％ (14/24),80.77％ (21/26) and 94.12％ (16/17) (x2 =15.6,P ＜ 0.05),and that of EGFR expression was 25.00％ (2/8),54.17％ (13/24),69.23 ％ (18/26) and 88.23 ％ (15/17) (x2 =10.70,P ＜ 0.05) in grades Ⅰ-Ⅵ of glioma respectively.Positive coexpression of CRM1 and EGFR was found in 40 cases,and negative coexpression of EGFR and CRM1 in 14 cases.The positive expression of EGFR and negative expression of CRM1 were found in 8cases,and negative expression of EGFR accompanied with positive expression of CRM1 in 13 cases (r =0.371,P ＜ 0.05).Conclusion Positive correlation between CRM1 and EGFR expression in glioma can be used as an important indicator to determine the prognosis of patients with glioma.
