中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
9期
1831-1832
,共2页
许孝飞%吴日乐%刘爱华%姜鹏%彭汤明%郭社卫%钱增辉%吴中学
許孝飛%吳日樂%劉愛華%薑鵬%彭湯明%郭社衛%錢增輝%吳中學
허효비%오일악%류애화%강붕%팽탕명%곽사위%전증휘%오중학
犬%兔%顶端动脉瘤%模型,动物
犬%兔%頂耑動脈瘤%模型,動物
견%토%정단동맥류%모형,동물
Canines%Rabbits%Terminal aneurysm%Model,animal
目的 建立犬与兔两种顶端动脉瘤模型并比较.方法 分别选用10条犬和25只兔,采用血管移植法结合酶诱导法分别制成犬与兔的顶端动脉瘤模型.结果 建立犬顶端动脉瘤模型10个,1例术后1d破裂,犬动脉瘤模型建立术后的直径为(5.20±0.37) mm(n=10),术后3周动脉瘤直径为(5.42±0.42) mm(n =9),两者差异无统计学意义(P＞0.05).建立兔顶端动脉瘤模型25个,3例分别于术后1、14、16d破裂,兔动脉瘤模型建立术后的直径为(2.10 ±0.22) mm(n=25),术后3周动脉瘤直径为(3.02±0.36) mm(n =22),两者差异有统计学意义(P＜0.05).结论 血管移植法结合酶诱导法制作动脉瘤模型成功率高、成本低,在形态、病理方面与临床动脉瘤更加相似.犬动脉瘤模型手术耐受力强、存活率高,适合行造影及介入栓塞实验.兔动脉瘤模型具有自发生长、自发破裂的生物学特点,适合进行组织学和病理学研究.
目的 建立犬與兔兩種頂耑動脈瘤模型併比較.方法 分彆選用10條犬和25隻兔,採用血管移植法結閤酶誘導法分彆製成犬與兔的頂耑動脈瘤模型.結果 建立犬頂耑動脈瘤模型10箇,1例術後1d破裂,犬動脈瘤模型建立術後的直徑為(5.20±0.37) mm(n=10),術後3週動脈瘤直徑為(5.42±0.42) mm(n =9),兩者差異無統計學意義(P＞0.05).建立兔頂耑動脈瘤模型25箇,3例分彆于術後1、14、16d破裂,兔動脈瘤模型建立術後的直徑為(2.10 ±0.22) mm(n=25),術後3週動脈瘤直徑為(3.02±0.36) mm(n =22),兩者差異有統計學意義(P＜0.05).結論 血管移植法結閤酶誘導法製作動脈瘤模型成功率高、成本低,在形態、病理方麵與臨床動脈瘤更加相似.犬動脈瘤模型手術耐受力彊、存活率高,適閤行造影及介入栓塞實驗.兔動脈瘤模型具有自髮生長、自髮破裂的生物學特點,適閤進行組織學和病理學研究.
목적 건립견여토량충정단동맥류모형병비교.방법 분별선용10조견화25지토,채용혈관이식법결합매유도법분별제성견여토적정단동맥류모형.결과 건립견정단동맥류모형10개,1례술후1d파렬,견동맥류모형건립술후적직경위(5.20±0.37) mm(n=10),술후3주동맥류직경위(5.42±0.42) mm(n =9),량자차이무통계학의의(P＞0.05).건립토정단동맥류모형25개,3례분별우술후1、14、16d파렬,토동맥류모형건립술후적직경위(2.10 ±0.22) mm(n=25),술후3주동맥류직경위(3.02±0.36) mm(n =22),량자차이유통계학의의(P＜0.05).결론 혈관이식법결합매유도법제작동맥류모형성공솔고、성본저,재형태、병리방면여림상동맥류경가상사.견동맥류모형수술내수력강、존활솔고,괄합행조영급개입전새실험.토동맥류모형구유자발생장、자발파렬적생물학특점,괄합진행조직학화병이학연구.
Objective To establish and compare terminal aneurysm models in canines and rabbits.Methods Terminal aneurysm models in 10 canines and 25 rabbits were established by using an arterial pouch pre-digested in vitro with combined elastase and collagenase.Results Ten terminal aneurysm models in canines were established,and one model ruptured at the first day after the construction.The aneurysmal models enlarged from the initial diameters of (5.20 ±0.37) mm (n =10) to (5.42 ±0.42) mm (n =9) at 3rd week after establishment (P ＞ 0.05).Twenty-five terminal aneurysm models in rabbits were established,and three models ruptured at the first day,14th day and 16th day respectively after the construction.The aneurysmal models enlarged from the initial diameters of (2.10 ± 0.22) mm (n =25) to (3.02 ±0.36) mm (n=22) at 3rd week after establishment (P＜0.05).Conclusion The successful rate of terminal aneurysm models in our group is high and the cost is low.The models are quite similar to the human intracranial aneurysm morphologically and pathologically.The models in canines endure more,have a high survival rate and are very useful for the study of angiography and embolization.The models in rabbits could spontaneously grow and rupture and are very useful for the study of histology and pathology.
