中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2013年
9期
1952-1954
,共3页
张家衡%杨泳%李杰宝%崔天盆%冯先华
張傢衡%楊泳%李傑寶%崔天盆%馮先華
장가형%양영%리걸보%최천분%풍선화
乳腺癌%肿瘤标志物%糖类抗原153%癌胚抗原
乳腺癌%腫瘤標誌物%糖類抗原153%癌胚抗原
유선암%종류표지물%당류항원153%암배항원
Breast cancer%Tumor marker%Carbohydrate antigen 153%Carcinoembryonic antigen
目的 探讨乳脂肪球表面生长因子8(MFGE8)、糖类抗原153(CA153)和癌胚抗原(CEA)在乳腺癌中的表达及其意义.方法 选取乳腺癌患者、乳腺纤维瘤患者和健康体检者各30例,采用酶联免疫吸附试验(ELISA)检测MFGE8水平,采用电化学发光法检测CA153、CEA水平.结果 乳腺癌患者血清中MFGE8、CA153、CEA分别为(6032.3±3043.7) ng/L、(58.72±28.80) U/ml、(4.35 ± 3.20) μg,/L,明显高于良性组和对照组,与两组间差异有统计学意义(P＜0.01).MFGE8、CA153、CEA诊断乳腺癌的敏感性分别为68.4％、55.9％、33.5％,良性组分别为8.1％、5.7％、3.1％,对照组分别为1.1％、0.7％、0.3％,各组间两两比较,差异有统计学意义(P＜0.05).三者联合检测的敏感性为86.3％；准确性分别为88.3％、63.3％、55.6％,三者联合检测为92.2％.结论 MFGE8、CA153、CEA联合检测可做为乳腺癌的预测指标.
目的 探討乳脂肪毬錶麵生長因子8(MFGE8)、糖類抗原153(CA153)和癌胚抗原(CEA)在乳腺癌中的錶達及其意義.方法 選取乳腺癌患者、乳腺纖維瘤患者和健康體檢者各30例,採用酶聯免疫吸附試驗(ELISA)檢測MFGE8水平,採用電化學髮光法檢測CA153、CEA水平.結果 乳腺癌患者血清中MFGE8、CA153、CEA分彆為(6032.3±3043.7) ng/L、(58.72±28.80) U/ml、(4.35 ± 3.20) μg,/L,明顯高于良性組和對照組,與兩組間差異有統計學意義(P＜0.01).MFGE8、CA153、CEA診斷乳腺癌的敏感性分彆為68.4％、55.9％、33.5％,良性組分彆為8.1％、5.7％、3.1％,對照組分彆為1.1％、0.7％、0.3％,各組間兩兩比較,差異有統計學意義(P＜0.05).三者聯閤檢測的敏感性為86.3％；準確性分彆為88.3％、63.3％、55.6％,三者聯閤檢測為92.2％.結論 MFGE8、CA153、CEA聯閤檢測可做為乳腺癌的預測指標.
목적 탐토유지방구표면생장인자8(MFGE8)、당류항원153(CA153)화암배항원(CEA)재유선암중적표체급기의의.방법 선취유선암환자、유선섬유류환자화건강체검자각30례,채용매련면역흡부시험(ELISA)검측MFGE8수평,채용전화학발광법검측CA153、CEA수평.결과 유선암환자혈청중MFGE8、CA153、CEA분별위(6032.3±3043.7) ng/L、(58.72±28.80) U/ml、(4.35 ± 3.20) μg,/L,명현고우량성조화대조조,여량조간차이유통계학의의(P＜0.01).MFGE8、CA153、CEA진단유선암적민감성분별위68.4％、55.9％、33.5％,량성조분별위8.1％、5.7％、3.1％,대조조분별위1.1％、0.7％、0.3％,각조간량량비교,차이유통계학의의(P＜0.05).삼자연합검측적민감성위86.3％；준학성분별위88.3％、63.3％、55.6％,삼자연합검측위92.2％.결론 MFGE8、CA153、CEA연합검측가주위유선암적예측지표.
Objective To discuss the expression and significance of milk fat globule epidermal growth factor 8 (MFGE8) and carbohydrate antigen 153 (CA153),carcinoembryonic antigen (CEA) in breast cancer.Methods 30 patients with breast cancer,30 patients with mammary gland fibroma and 30 healthy volunteers were selected.Eenzyme-linked immunosorbent assay was used to detect serum level of MFGES,and electrochemiluminescence immunoassay to detect serum level of CA153 and CEA.Results The serum levels of MFGE8,CA153 and CEA in patients with breast cancer were (6032.3 ±3043.7) ng/L,(58.72 ± 28.8) U/ml and (4.35 ± 3.2) μg/L respectively,which were significantly higher than others (P ＜ 0.01 for all).The positive rate of MFGES,CA153 and CEA in patients with breast cancer was 68.4％,55.9％ and 33.5％,that was 8.1％,5.7％ and 3.1％ in patients with mammary gland fibroma,and that was 1.1％,0.7％ and 0.3％ in control group,respectively.There was significant difference between each two groups (P ＜ 0.05).By combined detection of MFGE8,CA153 and CEA,the positive rate of breast cancer could be greatly improved to 86.3％.The accuracy of MFGE8,CA153 and CEA in patients with breast cancer was 88.3％,63.3％ and 55.6％ respectively.By combined detection of MFGE8,CA153 and CEA,the positive rate of breast cancer could be greatly improved to 92.2％.Conclusion The combined detection of MFGE8,CA153 and CEA can be used as predictors of breast cancer.
