CAJ | 학술논문

目的探讨抑癌基因p53和细胞核增殖抗原细胞核增殖抗原(Ki-67)在肝细胞肝癌中的表达及其临床意义.方法运用组织芯片和免疫组织化学法分别检测p53和Ki-67在87例肝细胞癌中的表达.结果在87例肝细胞癌患者中,p53的表达与组织学分型、淋巴结转移、血清甲胎蛋白(AFP)含量有相关(P＜0.05),与其他指标无明显相关(P＞0.05)；Ki-67的表达与组织学分型、临床分期、淋巴结转移有相关(P＜0.05),而与其他指标无明显相关(P＞0.05).p53和Ki-67阳性表达患者的中位生存时间相对于阴性表达患者均较短,且差异有统计学意义(x2=31.256,P＜0.01;x2 =41.366,P＜0.01),但两个指标之间差异无统计学意义(r=0.003,P＞0.05).结论 p53和Ki-67在肝细胞癌患者中的阳性表达与临床预后密切相关.
목적 탐토억암기인p53화세포핵증식항원세포핵증식항원(Ki-67)재간세포간암중적표체급기림상의의.방법 운용조직심편화면역조직화학법분별검측p53화Ki-67재87례간세포암중적표체.결과 재87례간세포암환자중,p53적표체여조직학분형、림파결전이、혈청갑태단백(AFP)함량유상관(P＜0.05),여기타지표무명현상관(P＞0.05)；Ki-67적표체여조직학분형、림상분기、림파결전이유상관(P＜0.05),이여기타지표무명현상관(P＞0.05).p53화Ki-67양성표체환자적중위생존시간상대우음성표체환자균교단,차차이유통계학의의(x2=31.256,P＜0.01;x2 =41.366,P＜0.01),단량개지표지간차이무통계학의의(r=0.003,P＞0.05).결론 p53화Ki-67재간세포암환자중적양성표체여림상예후밀절상관.
Objective To investigate the expression and clinical implications of p53 and proliferation cell nuclear antigen (Ki-67) in hepatocellular carcinoma (HCC).Methods Tissue microarray and immunohistochemistry (IHC) were used to detect the expression of p53 and Ki-67 in 87 HCC patients.Results The positive expression of p53 was correlated to the histological grade,lymph node metastasis and serum AFP level (P ＜ 0.05),but not to other clinical factors (P ＞ 0.05).The expression of Ki-67 in HCC patients was correlated with histological grade,TNM stage and lymph node metastasis (P ＜ 0.05),but not to other clinical factors (P ＞ 0.05).Among the patients positive for the expression of p53 and Ki67,their middle survival months were shorter than those negative for the expression (x2 =31.256,P ＜0.01;x2 =41.366,P＜ 0.01).The expression of p53 had no correlation with the expression of Ki-67 (r =0.003,P ＞ 0.05).Conclusion The positive expression of p53 and Ki-67 correlates with the clinical prognosis of HCC.