CAJ | 학술논문

目的探讨丛生蛋白在胰腺导管癌中的表达及其临床意义.方法用免疫组织化学方法对52例胰腺导管癌组织进行检测,计算阳性率并以各项临床指标进行统计学分析.结果有32.7％的胰腺导管癌表达丛生蛋白;丛生蛋白的表达与淋巴结的转移明显相关(P＜0.05),但与神经淋巴管、血管的侵犯无明显相关(P＞0.05),与患者术前血糖链抗原19-9(CA19-9)水平无明显相关(P＞0.05),与癌胚抗原(CEA)水平明显相关(P＜0.05),但与癌肿的分化、分期大小无明显相关(P＞0.05).丛生蛋白的表达与患者生存率无明显相关(P＞0.05),但生存率与淋巴结转移明显相关(P＜0.05).结论丛生蛋白可作为分子生物学预后因子在胰腺导管癌的预后判断上起一定作用.
목적 탐토총생단백재이선도관암중적표체급기림상의의.방법 용면역조직화학방법대52례이선도관암조직진행검측,계산양성솔병이각항림상지표진행통계학분석.결과 유32.7％적이선도관암표체총생단백;총생단백적표체여림파결적전이명현상관(P＜0.05),단여신경림파관、혈관적침범무명현상관(P＞0.05),여환자술전혈당련항원19-9(CA19-9)수평무명현상관(P＞0.05),여암배항원(CEA)수평명현상관(P＜0.05),단여암종적분화、분기대소무명현상관(P＞0.05).총생단백적표체여환자생존솔무명현상관(P＞0.05),단생존솔여림파결전이명현상관(P＜0.05).결론 총생단백가작위분자생물학예후인자재이선도관암적예후판단상기일정작용.
Objective To trace the expression pattern of clusterin in pancreatic adenocarcinoma and investigate the relationship between clusterin and clinicopathologic features.Methods Clusterin was detected by immunohistouchemical staining in 52 cases of pancreatic adenocacinoma.The positive rate and survival time were analyzed.Results Clusterin was expressed in tumor cells (32.7％) and clusterin expression showed significant correlations with lymph node metastasis (P ＜ 0.05) and preoperative serum carcinoembryonic antigen (CEA) level (P ＜ 0.05).However,no significant relationship was found between clusterin expression and cancer differentiation,carbohydrate antigen 19-9 (CA19-9) or lymphovascular invasion (P ＞ 0.05).Prognostically,clusterin expression had no significant correlation with survival (P ＞ 0.05),while survival had a strong correlation with lymph node metastasis (P ＞ 0.05).Conclusion Clusterin can be a potential molecular biologic prognostic marker for pancreatic adenocarcinoma.