中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
4期
887-888
,共2页
初发脑梗死%同型半胱氨酸%白细胞介素-1β%肿瘤坏死因子-α%抑郁
初髮腦梗死%同型半胱氨痠%白細胞介素-1β%腫瘤壞死因子-α%抑鬱
초발뇌경사%동형반광안산%백세포개소-1β%종류배사인자-α%억욱
Primary cerebral infarction%Homocysteine%Interleukin-1β%Tumor necrosis factor-α%Depression
目的 探讨初发脑梗死患者同型半胱氨酸、白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α水平与并发焦虑抑郁状态的相关性.方法 收集发生脑梗死患者98例,根据其预后将其分为脑梗死后抑郁组42例和脑梗死后非抑郁组56例,比较两组患者血清IL-1β、TNF-α水平和血浆HCY水平以及进一步的分析抑郁严重程度与血清IL-1β、TNF-α水平和血浆HCY水平的关系.结果 脑梗死抑郁组患者的血清IL-1β[(39.28 ±4.35) ng/L]、TNF-α水平[(35.62 ±6.21) ng/L]和血浆HCY水平[(18.02 ±5.44) μmol/L]明显高于非抑郁组[分别为(18.52 ±3.21)、(21.24±3.83) ng/L、(10.98 ±2.56) μmol/L],差异有统计学意义(P＜0.05).Pearson相关分析结果显示抑郁患者抑郁严重程度与血清IL-1β、TNF-α水平和血浆HCY水平呈正相关(r=0.781 3,P＜0.05).结论 高HCY和高血清IL-1β、TNF-α浓度可能是脑梗死后抑郁发生的危险因素,临床上通过检测血浆HCY和血清IL-1β、TNF-α浓度水平可以在一定程度上反映抑郁的严重程度.
目的 探討初髮腦梗死患者同型半胱氨痠、白細胞介素(IL)-1β、腫瘤壞死因子(TNF)-α水平與併髮焦慮抑鬱狀態的相關性.方法 收集髮生腦梗死患者98例,根據其預後將其分為腦梗死後抑鬱組42例和腦梗死後非抑鬱組56例,比較兩組患者血清IL-1β、TNF-α水平和血漿HCY水平以及進一步的分析抑鬱嚴重程度與血清IL-1β、TNF-α水平和血漿HCY水平的關繫.結果 腦梗死抑鬱組患者的血清IL-1β[(39.28 ±4.35) ng/L]、TNF-α水平[(35.62 ±6.21) ng/L]和血漿HCY水平[(18.02 ±5.44) μmol/L]明顯高于非抑鬱組[分彆為(18.52 ±3.21)、(21.24±3.83) ng/L、(10.98 ±2.56) μmol/L],差異有統計學意義(P＜0.05).Pearson相關分析結果顯示抑鬱患者抑鬱嚴重程度與血清IL-1β、TNF-α水平和血漿HCY水平呈正相關(r=0.781 3,P＜0.05).結論 高HCY和高血清IL-1β、TNF-α濃度可能是腦梗死後抑鬱髮生的危險因素,臨床上通過檢測血漿HCY和血清IL-1β、TNF-α濃度水平可以在一定程度上反映抑鬱的嚴重程度.
목적 탐토초발뇌경사환자동형반광안산、백세포개소(IL)-1β、종류배사인자(TNF)-α수평여병발초필억욱상태적상관성.방법 수집발생뇌경사환자98례,근거기예후장기분위뇌경사후억욱조42례화뇌경사후비억욱조56례,비교량조환자혈청IL-1β、TNF-α수평화혈장HCY수평이급진일보적분석억욱엄중정도여혈청IL-1β、TNF-α수평화혈장HCY수평적관계.결과 뇌경사억욱조환자적혈청IL-1β[(39.28 ±4.35) ng/L]、TNF-α수평[(35.62 ±6.21) ng/L]화혈장HCY수평[(18.02 ±5.44) μmol/L]명현고우비억욱조[분별위(18.52 ±3.21)、(21.24±3.83) ng/L、(10.98 ±2.56) μmol/L],차이유통계학의의(P＜0.05).Pearson상관분석결과현시억욱환자억욱엄중정도여혈청IL-1β、TNF-α수평화혈장HCY수평정정상관(r=0.781 3,P＜0.05).결론 고HCY화고혈청IL-1β、TNF-α농도가능시뇌경사후억욱발생적위험인소,림상상통과검측혈장HCY화혈청IL-1β、TNF-α농도수평가이재일정정도상반영억욱적엄중정도.
Objective To explore the relation between homocysteine (HCY),interleukin (IL)-1β,tumor necrosis factor (TNF)-α levels in the patients with primary cerebral infarction and anxiety and depression symptoms.Methods 98 patients who stayed at the hospital' s inpatient department between August 2012 and October 2013with primary cerebral infarction were selected,and divided into two groups based on their prognosis:42 depressed patients with cerebral infarction and 56 non-depressed counterparts.Then the serum IL-1β,TNF-α and plasma HCY levels in the patients of two groups were compared,and the relation between the severity of depression and serum IL-1β,TNF-α and plasma HCY levels in the patients was further analyzed.Results The serum IL-1β[(39.28 ±4.35) ng/L],TNF-α [(35.62 ±6.21) ng/L] and plasma HCY [(18.02 ±5.44) μmol/L] levels in the patients of the depression group were distinctly higher than that of non-depression group [(18.52 ± 3.21),(21.24 ± 3.83) ng/L,(10.98 ± 2.56) μmol/L],and the difference was statistically significant (P ＜ 0.05).According to Pearson relevant analysis results,the severity of depression in depression group was positively correlated with the serum IL-1β,TNF-α and plasma HCY levels (r =0.781 3,P ＜ 0.05).Conclusion High serum IL-1β,TNF-α and plasma HCY levels could be the risk factors leading to depression of patients with cerebral infarction.The clinically tested serum IL-1β,TNF-α and plasma HCY levels in part reflect the severity of depression,and guide the clinical treatment and prognosis of patients with cerebral infarction.In addition,these levels can be used as effective clinical monitoring indexes to show the severity of depression of patients with cerebral infarction,having great value of clinical application.
