CAJ | 학술논문

目的探讨使用氨甲环酸是否能够安全、有效地减少全髋关节置换术围手术期的出血量和输血率.方法将100例行全髋关节置换术患者随机平均分为两组,氨甲环酸组于切皮前15 min将氨甲环酸按20 mg/kg单一剂量静脉输注,对照组同时间点给予等量生理盐水.对比术后2d的血红蛋白减少量、输血量、输血人数和术后静脉血栓形成风险的差异.结果氨甲环酸组患者血红蛋白减少量、输血量和输血人数分别为(44.3±13.2) g/L、(338.8 ±92.7) ml、13例(26％),低于对照组的(53.4±8.9) g/L、(459.7±188.5)ml、29例(58％,P＜0.05);两组患者术后深静脉血栓发生率差异无统计学意义(P＞0.05).结论氨甲环酸能够减少全髋关节置换术患者围手术期的出血量和输血率,不增加术后血栓形成的风险.
목적 탐토사용안갑배산시부능구안전、유효지감소전관관절치환술위수술기적출혈량화수혈솔.방법 장100례행전관관절치환술환자수궤평균분위량조,안갑배산조우절피전15 min장안갑배산안20 mg/kg단일제량정맥수주,대조조동시간점급여등량생리염수.대비술후2d적혈홍단백감소량、수혈량、수혈인수화술후정맥혈전형성풍험적차이.결과 안갑배산조환자혈홍단백감소량、수혈량화수혈인수분별위(44.3±13.2) g/L、(338.8 ±92.7) ml、13례(26％),저우대조조적(53.4±8.9) g/L、(459.7±188.5)ml、29례(58％,P＜0.05);량조환자술후심정맥혈전발생솔차이무통계학의의(P＞0.05).결론 안갑배산능구감소전관관절치환술환자위수술기적출혈량화수혈솔,불증가술후혈전형성적풍험.
Objective To investigate the efficacy and safety of single preoperative dose tranexamic acid use for perioperative blood loss control in patients having primary total hip arthroplasty.Methods One hundred patients having primary total hip arthroplasty were randomly divided into 2 groups,the tranexamic acid group and the control group,with 50 patients in each.In the tranexamic acid group,a single dose of 20 mg/kg was infused intravenously within 15 minutes before skin incision,while an equal volume of normal saline was given instead in the control group.Hemoglobin losses,blood transfusion volume and blood transfusion rate of these two groups were measured before and two days after operation,the comparative analysis was conducted.Deep vein thrombosis was also observed in these two groups.Results Hemoglobin losses,blood transfusion volume and blood transfusion rate in the tranexamic acid group were (44.3 ± 13.2) g/L,(338.8 ±92.7) ml,13 (26％),lower than the control group (53.4 ± 8.9) g/L,(459.7 ± 188.5) ml,29 (58％) (P ＜ 0.05); while no significant difference was detected in the incidence of venous thrombosis (P ＞ 0.05).Conclusion Tranexamic acid use preoperatively can reduce perioperative blood loss without increasing risk for venous thrombosis.