CAJ | 학술논문

目的观察心脏辅助装置对于急性心力衰竭(HF,简称心衰)犬血流动力学参数的影响.方法 10条健康犬,体质量25～ 35 kg,应用冠状动脉(简称冠脉)微栓塞法建立急性心衰模型,对于造模成功的犬采用双心室辅助,并在实验开始时采用1∶1的频率辅助,记录主动脉压力、心输出量等血流动力学参数.结果冠脉微栓塞使心输出量[CO:(2.88±0.38) L/min比(1.58±0.23) L/min]、平均动脉压[MAP:(117.2±9.0) mmHg(1 mmHg =0.133 kPa)比(75.0±6.7)mmHg]等其他血流动力学参数减少(30％～50％).通过应用心脏直接辅助装置,能提高心输出量[CO:(1.58±0.23) L/min比(2.41±0.34) L/min]和平均动脉压[MAP:(75.0±6.7) mmHg比(103.8±10.0) mmHg],CO和MAP增加20％.收缩压[(93.6±8.03) mmHg比(126.8±7.8)mmHg]、舒张压[(60.4±5.0) mmHg比(87.0 ±6.1)mmHg]也相应提高,差异有统计学意义(P＜0.05).辅助前后心率变化不大[(125.4±9.0)次/分比(129.0±10.3)次/分],差异无统计学意义(P＞0.05).结论与心脏收缩同步的心脏辅助装置对于急性心衰犬能够改善心脏的收缩能力,辅助心脏的收缩,提高其心输出量,使其血流动力学参数得以提高.
목적 관찰심장보조장치대우급성심력쇠갈(HF,간칭심쇠)견혈류동역학삼수적영향.방법 10조건강견,체질량25～ 35 kg,응용관상동맥(간칭관맥)미전새법건립급성심쇠모형,대우조모성공적견채용쌍심실보조,병재실험개시시채용1∶1적빈솔보조,기록주동맥압력、심수출량등혈류동역학삼수.결과 관맥미전새사심수출량[CO:(2.88±0.38) L/min비(1.58±0.23) L/min]、평균동맥압[MAP:(117.2±9.0) mmHg(1 mmHg =0.133 kPa)비(75.0±6.7)mmHg]등기타혈류동역학삼수감소(30％～50％).통과응용심장직접보조장치,능제고심수출량[CO:(1.58±0.23) L/min비(2.41±0.34) L/min]화평균동맥압[MAP:(75.0±6.7) mmHg비(103.8±10.0) mmHg],CO화MAP증가20％.수축압[(93.6±8.03) mmHg비(126.8±7.8)mmHg]、서장압[(60.4±5.0) mmHg비(87.0 ±6.1)mmHg]야상응제고,차이유통계학의의(P＜0.05).보조전후심솔변화불대[(125.4±9.0)차/분비(129.0±10.3)차/분],차이무통계학의의(P＞0.05).결론 여심장수축동보적심장보조장치대우급성심쇠견능구개선심장적수축능력,보조심장적수축,제고기심수출량,사기혈류동역학삼수득이제고.
Objective To observe the effects of direct cardiac compression device (DCC) on hemodynamic parameters of acute heart failure in dogs.Methods Ten healthy clean dogs (body weight 2535 kg) were used in this study,The coronary micro embolization method was used to establish the acute heart failure model.For the successful models,the biventricular assist was used,with a 1:1 assisted frequency at the beginning of the experiment.The aortic pressure,cardiac output and other hemodynamic parameters were recorded.Results By using coronary micro embolization method,cardiac output (CO) was reduced from (2.88± 0.38) L/min to (1.58 ± 0.23) L/min and mean arterial pressure (MAP) increased from (75.0 ±6.7) mmHg (1 mmHg =0.133 kPa) to (103.8 ± 10.0) mmHg.The application of direct cardiac assist devices could increase CO [(1.58 ±0.23) L/min vs.(2.41 ±0.34) L/min] and MAP [(75.0±6.7) mmHg vs.(103.8 ± 10.0) mmHg] by about 20％.Systolic arterial pressure (SAP) [(93.6±8.03) mmHg to (126.8 ±7.8) mmHg] and diastolic arterial pressure (DAP) [(60.4 ± 5.0) mmHg to (87.0 ± 6.1) mmHg] could be increased.The difference was statistically significant in SAP and DAP (P ＜ 0.05).The heart rate had little change from (125.4 ± 9.0) to (129.0 ± 10.3)beats/min (P ＞ 0.05).Conclusion Direct cardiac compression device for systolic synchronization of dogs with acute heart failure could improve systolic contractility and increase CO,leading to the improvement of other hemodynamic parameters.