中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
8期
1632-1634,封3
,共4页
肺癌%磷酸果糖激酶4
肺癌%燐痠果糖激酶4
폐암%린산과당격매4
Lung cancer%6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
目的 探讨磷酸果糖激酶4(PFKFB4)在男性肺癌患者中的表达及预后意义.方法 免疫组织化学法检测90例男性肺癌组织及20例正常肺组织PFKFB4蛋白的表达,分析其表达与临床病理参数及患者预后的关系.结果 PFKFB4在肺癌组织中的阳性表达率明显高于正常肺组织(65.6％比0,P＜0.05).PFKFB4在肺癌组织中的表达与吸烟史、淋巴结转移及TNM分期密切相关(P＜0.05).Kaplan-Meier法显示PFKFB4高表达的中位生存期为24个月,明显低于低表达组(60个月),差异有统计学意义(P＜0.05).多因素Cox回归分析显示PFKFB4表达可作为肺癌患者术后生存时间评估的独立因子(P＜0.05).结论 PFKFB4在男性肺癌的发展中起重要作用,有助于肺癌患者的预后评估.
目的 探討燐痠果糖激酶4(PFKFB4)在男性肺癌患者中的錶達及預後意義.方法 免疫組織化學法檢測90例男性肺癌組織及20例正常肺組織PFKFB4蛋白的錶達,分析其錶達與臨床病理參數及患者預後的關繫.結果 PFKFB4在肺癌組織中的暘性錶達率明顯高于正常肺組織(65.6％比0,P＜0.05).PFKFB4在肺癌組織中的錶達與吸煙史、淋巴結轉移及TNM分期密切相關(P＜0.05).Kaplan-Meier法顯示PFKFB4高錶達的中位生存期為24箇月,明顯低于低錶達組(60箇月),差異有統計學意義(P＜0.05).多因素Cox迴歸分析顯示PFKFB4錶達可作為肺癌患者術後生存時間評估的獨立因子(P＜0.05).結論 PFKFB4在男性肺癌的髮展中起重要作用,有助于肺癌患者的預後評估.
목적 탐토린산과당격매4(PFKFB4)재남성폐암환자중적표체급예후의의.방법 면역조직화학법검측90례남성폐암조직급20례정상폐조직PFKFB4단백적표체,분석기표체여림상병리삼수급환자예후적관계.결과 PFKFB4재폐암조직중적양성표체솔명현고우정상폐조직(65.6％비0,P＜0.05).PFKFB4재폐암조직중적표체여흡연사、림파결전이급TNM분기밀절상관(P＜0.05).Kaplan-Meier법현시PFKFB4고표체적중위생존기위24개월,명현저우저표체조(60개월),차이유통계학의의(P＜0.05).다인소Cox회귀분석현시PFKFB4표체가작위폐암환자술후생존시간평고적독립인자(P＜0.05).결론 PFKFB4재남성폐암적발전중기중요작용,유조우폐암환자적예후평고.
Objective To investigate the expression and prognostic significance of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) in male patients with lung cancer.Methods PFKFB4 protein expression was detected in 90 cases of lung cancer and 20 cases of normal lung tissue by immunohistochemistry,and the relationship of PFKFB4 protein expression with clinicopathological characteristics and prognosis was evaluated.Results The positive rate of PFKFB4 in lung cancer tissues was significantly higher than that in normal lung tissue (65.6％ vs.0％,P ＜0.05).PFKFB4 expression was associated with smoking history,lymph node metastasis and TNM stage in lung cancer (P ＜ 0.05).Kaplan-Meier method showed the median survival time (24 months) of patients with PFKFB4 high-expression was significantly shortened as compared with that in patients with PFKFB4 low-expression (60 months) (P ＜ 0.05).Multivariate Cox regression analysis showed PFKFB4 could be used as an independent factor for prognostic evaluation in lung cancer (P ＜ 0.05).Conclusion PFKFB4 may play an important role in the development of lung cancer and may be used as a marker to evaluate the prognosis of male patients with lung cancer.
