CAJ | 학술논문

目的探讨胶质母细胞瘤转录因子(Gli1)在肺腺癌中的表达及其意义.方法采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶(SP)法检测40例肺腺癌组织及40例癌旁组织中的Gli1蛋白的表达,并对肺腺癌组中Gli1的表达与临床病理特征之间的关系进行分析.结果 40例肺腺癌组织中的Gli1阳性率为100％,40例癌旁组织中的Gli1阳性率为0,两组Gli1阳性表达率差异有统计学意义(P＜0.01);肺腺癌组中Gli1阳性表达率与分化程度、淋巴结是否转移明显相关(P＜0.05),而Gli1阳性表达率与年龄、性别、肿瘤大小及TNM分期无明显相关(P＞0.05).结论 Gli1在肺腺癌进展中具有重要作用.
목적 탐토효질모세포류전록인자(Gli1)재폐선암중적표체급기의의.방법 채용면역조직화학련매균항생물소단백-과양화물매(SP)법검측40례폐선암조직급40례암방조직중적Gli1단백적표체,병대폐선암조중Gli1적표체여림상병리특정지간적관계진행분석.결과 40례폐선암조직중적Gli1양성솔위100％,40례암방조직중적Gli1양성솔위0,량조Gli1양성표체솔차이유통계학의의(P＜0.01);폐선암조중Gli1양성표체솔여분화정도、림파결시부전이명현상관(P＜0.05),이Gli1양성표체솔여년령、성별、종류대소급TNM분기무명현상관(P＞0.05).결론 Gli1재폐선암진전중구유중요작용.
Objective To investigate the expression of gioblastoma transcriptional factor (Gli1) and its significance in lung adenocarcinoma.Methods Gli1 protein in 40 cases of lung adenocarcinoma tissues and 40 cases of adjacent normal tissues was detected by the immunohistochemical streptavid-in-peroxidase (SP) method.The relationship between the expression of Gli1 protein and clinicopathological features in lung adenocarcinoma was analyzed.Results The positive rate of Gli1 in 40 cases of lung adenocarcinoma was 100％,and that was 0 in the adjacent normal tissues (P ＜0.01).Gli1 positive expression rate was significantly correlated with degree of differentiation of lung adenocarcinoma and lymph node metastasis (P ＜0.05),but not with age,gender,tumor size,histological type and TNM stage (P ＞ 0.05).Conclusion Gli1 may play an important role in the progression of lung cancer.