中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
8期
1808-1810
,共3页
胆囊癌%高迁移率族蛋白B1%p53%免疫组织化学
膽囊癌%高遷移率族蛋白B1%p53%免疫組織化學
담낭암%고천이솔족단백B1%p53%면역조직화학
Gallbladder carcinoma%High mobility group protein B1%p53%Immunohistochemistry
目的 探讨高迁移率族蛋白B1(HMGB1)和p53在胆囊癌组织中的表达及意义.方法 应用免疫组织化学的方法测定HMGB1及p53在30例胆囊癌及30例胆囊良性病变组织中的表达,来探讨HMGB1及p53和胆囊癌生物学特性之间的关系.结果 HMGB1和p53在胆囊癌组中的阳性表达率分别为83.3％(25/30)和76.7％(23/30),显著高于其在胆囊良性病变的阳性表达率(分别为16.7％、13.3％,P＜0.05).HMGB1和p53在胆囊癌组中的阳性表达与胆囊癌患者的性别、年龄及病理组织学类型无相关(P＞0.05),而与胆囊癌的临床分期和分化程度明显相关(P＜0.05).HMGB1和p53在胆囊癌组中的阳性表达明显相关(r=0.526,P＜0.05).结论 HMGB1和p53在胆囊癌中呈高表达.HMGB1和p53在胆囊癌的发生、发展和侵袭中共同发挥作用.
目的 探討高遷移率族蛋白B1(HMGB1)和p53在膽囊癌組織中的錶達及意義.方法 應用免疫組織化學的方法測定HMGB1及p53在30例膽囊癌及30例膽囊良性病變組織中的錶達,來探討HMGB1及p53和膽囊癌生物學特性之間的關繫.結果 HMGB1和p53在膽囊癌組中的暘性錶達率分彆為83.3％(25/30)和76.7％(23/30),顯著高于其在膽囊良性病變的暘性錶達率(分彆為16.7％、13.3％,P＜0.05).HMGB1和p53在膽囊癌組中的暘性錶達與膽囊癌患者的性彆、年齡及病理組織學類型無相關(P＞0.05),而與膽囊癌的臨床分期和分化程度明顯相關(P＜0.05).HMGB1和p53在膽囊癌組中的暘性錶達明顯相關(r=0.526,P＜0.05).結論 HMGB1和p53在膽囊癌中呈高錶達.HMGB1和p53在膽囊癌的髮生、髮展和侵襲中共同髮揮作用.
목적 탐토고천이솔족단백B1(HMGB1)화p53재담낭암조직중적표체급의의.방법 응용면역조직화학적방법측정HMGB1급p53재30례담낭암급30례담낭량성병변조직중적표체,래탐토HMGB1급p53화담낭암생물학특성지간적관계.결과 HMGB1화p53재담낭암조중적양성표체솔분별위83.3％(25/30)화76.7％(23/30),현저고우기재담낭량성병변적양성표체솔(분별위16.7％、13.3％,P＜0.05).HMGB1화p53재담낭암조중적양성표체여담낭암환자적성별、년령급병리조직학류형무상관(P＞0.05),이여담낭암적림상분기화분화정도명현상관(P＜0.05).HMGB1화p53재담낭암조중적양성표체명현상관(r=0.526,P＜0.05).결론 HMGB1화p53재담낭암중정고표체.HMGB1화p53재담낭암적발생、발전화침습중공동발휘작용.
Objective To study the expression and significance of high mobility group box protein-1 (HMGB1) and p53 in gallbladder carcinoma.Methods The expression of HMGB1 and p53 in 30 cases of gallbladder carcinoma tissues and 30 cases of gallbladder benign lesions was detected by immunohistochemistry,and their correlation with clinicopathological features of gallbladder carcinoma was analyzed.Results The positive expression rate of HMGB1 and p53 in gallbladder carcinoma was 83.3％ (25/30) and 76.7％ (23/30) respectively,significantly higher than in gallbladder benign lesions (16.7％ and 13.3％ respectively,P ＜ 0.05).The expression of HMGB1 and p53 in gallbladder carcinoma was not related with age,sex,and histologic type (P ＞ 0.05),but significantly correlated with clinical stage and differentiation (P ＜ 0.05).There was obvious correlation between the expression of HMGB1 and p53 in gallbladder carcinoma (r =0.526,P ＜ 0.05).Conclusion Both HMGB1 and p53 were up-regulated in gallbladder carcinoma,suggesting their synergistic effects played in the carcinogenesis,development and invasion of gallbladder carcinoma.
