CAJ | 학술논문

目的探讨人斯钙素2蛋白(STC2)在胃癌组织中的表达及其临床意义.方法应用免疫组织化学技术[链霉菌抗生物素蛋白-过氧化物酶(SP)三步法]检测STC2在50例胃癌组织中的表达,并选取40例癌旁黏膜组织作为对照组.回顾性分析胃癌患者的临床病理特征与STC2表达的关系.结果 STC2在胃癌组织和癌旁黏膜组织中阳性表达率为分别为68.00％和35.00％,差异有统计学意义(P＜0.01).胃癌组织中,侵犯黏膜层和肌层组STC2的阳性表达率为38.46％,明显低于侵及浆膜层及浆膜外组的78.38％,差异有统计学意义(P＜0.01);淋巴结转移组的阳性表达率为80.65％,高于无转移组的42.11％,差异有统计学意义(P＜0.05);而不同性别、年龄、肿瘤大小、组织分化、TNM分期和远处转移的STC2表达水平差异无统计学意义(P＞0.05).STC2在不同浸润程度组和不同淋巴转移组中阳性表达强度均不同,差异有统计学意义(P＜ 0.05).结论 STC2的表达与胃癌的浸润、淋巴结转移密切相关,可能是胃癌侵袭转移的促进因素之一,使胃癌的恶性程度增加.
목적 탐토인사개소2단백(STC2)재위암조직중적표체급기림상의의.방법 응용면역조직화학기술[련매균항생물소단백-과양화물매(SP)삼보법]검측STC2재50례위암조직중적표체,병선취40례암방점막조직작위대조조.회고성분석위암환자적림상병리특정여STC2표체적관계.결과 STC2재위암조직화암방점막조직중양성표체솔위분별위68.00％화35.00％,차이유통계학의의(P＜0.01).위암조직중,침범점막층화기층조STC2적양성표체솔위38.46％,명현저우침급장막층급장막외조적78.38％,차이유통계학의의(P＜0.01);림파결전이조적양성표체솔위80.65％,고우무전이조적42.11％,차이유통계학의의(P＜0.05);이불동성별、년령、종류대소、조직분화、TNM분기화원처전이적STC2표체수평차이무통계학의의(P＞0.05).STC2재불동침윤정도조화불동림파전이조중양성표체강도균불동,차이유통계학의의(P＜ 0.05).결론 STC2적표체여위암적침윤、림파결전이밀절상관,가능시위암침습전이적촉진인소지일,사위암적악성정도증가.
Objective To investigate the expression of human Stanniocalcin 2 (STC2) protein in gastric cancer (GC) tissue and its clinical significance.Methods Immunohistochemistry were conducted to detect STC2 expression in paraffin-embedded gastric cancer tissues of 50 cases and normal gastric mucosa of 40 cases.The relationship between the expression of STC2 and the clinical pathological characteristics was explored.The clinical and pathologic parameters for this study included sex,age,maximum tumor size,depth of invasion,lymphatic metastasis,tumor stage,histologic grade,and distant metastasis.Resuits The positive expression rates of STC2 in 50 gastric cancer tissues is significantly higher than in 40 normal tissues (68.00％＞ 35.00％,P ＜ 0.01).STC2 expression was significantly higher in cases with serosa-invasion (78.38％) than in those without serosa-invasion (38.46％) (P ＜ 0.01).And the lymphatic metastasis group had a higher rate of STC2 expression than that without lymphatic metastasis group (80.65％＞42.11％,P ＜ 0.05).However,the other parameters,including sex ratio,age,maximum tumor size,histologic grade,tumor stage and distant metastasis,did not show signifi-cant differences in STC2 expression (P ＞ 0.05).The expressive intensity of STC2 was correlated with depth of invasion and lymphatic metastasis,the differences were statistically significant (P ＜ 0.05).Conclusion The expression of STC2 in gastric cancer is correlated to the tumor invasion and lymphatic metastasis,it may serve as one of the factors that promote the invasion and metastasis and increase the malignant degree in the development of GC.