CAJ | 학술논문

目的探讨首次前列腺穿刺活检病理结果为阴性但仍高度怀疑为前列腺癌的前列腺特异性抗原(PSA)升高患者需行重复穿刺活检的预测因素.方法 112例重复穿刺患者根据第2次活检病理结果分为前列腺癌组33例和非癌组79例.比较两组患者的临床资料并确定重复穿刺活检的阳性预测因素.结果两组间PSA密度(PSAD)、前列腺移行区体积(TZV)和首次穿刺结果为高级别上皮内瘤变(HGPIN)比较差异有统计学意义(P＜0.05).回归分析显示,PSAD和TZV是前列腺重复穿刺结果为前列腺癌的高危因素.结论对于首次穿刺活检病理结果为阴性但PSA升高患者,PSAD和TZV可作为其接受再活检的预测因素.
목적 탐토수차전렬선천자활검병리결과위음성단잉고도부의위전렬선암적전렬선특이성항원(PSA)승고환자수행중복천자활검적예측인소.방법 112례중복천자환자근거제2차활검병리결과분위전렬선암조33례화비암조79례.비교량조환자적림상자료병학정중복천자활검적양성예측인소.결과 량조간PSA밀도(PSAD)、전렬선이행구체적(TZV)화수차천자결과위고급별상피내류변(HGPIN)비교차이유통계학의의(P＜0.05).회귀분석현시,PSAD화TZV시전렬선중복천자결과위전렬선암적고위인소.결론 대우수차천자활검병리결과위음성단PSA승고환자,PSAD화TZV가작위기접수재활검적예측인소.
Objective The predictive factors of prostate cancer at repeat biopsy in patients with elevated serum total prostate specific antigen (tPSA) after initial negative biopsy.Methods A total of 112 men with suspected prostate cancer underwent prostate biopsy.All of them were diagnosed as having negative results and received the second biopsy.They were divided into a prostate cancer group (33 cases) and a non-cancer group (79 cases) according to the final pathological diagnosis from the second biopsy.We analyzed and compared the clinical characteristics of the two groups to determine the predictors for the repeat biopsy pathology results of prostate cancer.Results There were significant differences in high grade intraepithelial neoplasm (HGPIN),PSA density (PSAD) and transitional zone volume (TZV) between the two groups.The logistic regression analysis showed that PSAD and TZV had a statistically significant correlation with cancer detection.Conclusion PSAD and TZV are predictive factors of prostate cancer in patients with an initial negative biopsy of elevated PSA levels.Early repeat biopsy is especially recommended in cases with high parameters which are mentioned above.