中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
9期
1871-1873
,共3页
胶质瘤%微小RNA-145%基因表达%预后
膠質瘤%微小RNA-145%基因錶達%預後
효질류%미소RNA-145%기인표체%예후
Glioma%MicroRNA-145%Gene expression%Prognosis
目的 探讨微小RNA(miR)-145在胶质瘤中的表达及其与临床病理特征之间的关系,评估其在预测胶质瘤患者预后中的价值.方法 检测96例胶质瘤及26例正常脑组织中miR-145的表达水平,用Kaplan-Meier法评估胶质瘤患者累积生存率和无进展生存率.结果 miR-145在胶质瘤中表达水平显著低于正常脑组织(P＜0.01);miR-145的表达和胶质瘤世界卫生组织(WHO)分级、KPS评分、复发时间及生存时间显著相关(P＜0.05),而与患者年龄、性别、肿瘤部位、大小、肿瘤切除范围、辅助治疗方式等无明显相关(P ＞0.05);miR-145高表达患者与低表达患者生存时间分别为(45.89±2.53)、(36.29±2.88)个月,差异有统计学意义(P＜0.05);miR-145低表达胶质瘤患者死亡风险比(HR)为miR-145高表达胶质瘤患者的2.023倍(95％可信区间:1.107 ～3.695,P＜0.05).结论 miR-145在胶质瘤中起到抑制肿瘤的作用.胶质瘤中miR-145异常低表达,其表达水平与胶质瘤患者生存时间呈正相关.
目的 探討微小RNA(miR)-145在膠質瘤中的錶達及其與臨床病理特徵之間的關繫,評估其在預測膠質瘤患者預後中的價值.方法 檢測96例膠質瘤及26例正常腦組織中miR-145的錶達水平,用Kaplan-Meier法評估膠質瘤患者纍積生存率和無進展生存率.結果 miR-145在膠質瘤中錶達水平顯著低于正常腦組織(P＜0.01);miR-145的錶達和膠質瘤世界衛生組織(WHO)分級、KPS評分、複髮時間及生存時間顯著相關(P＜0.05),而與患者年齡、性彆、腫瘤部位、大小、腫瘤切除範圍、輔助治療方式等無明顯相關(P ＞0.05);miR-145高錶達患者與低錶達患者生存時間分彆為(45.89±2.53)、(36.29±2.88)箇月,差異有統計學意義(P＜0.05);miR-145低錶達膠質瘤患者死亡風險比(HR)為miR-145高錶達膠質瘤患者的2.023倍(95％可信區間:1.107 ～3.695,P＜0.05).結論 miR-145在膠質瘤中起到抑製腫瘤的作用.膠質瘤中miR-145異常低錶達,其錶達水平與膠質瘤患者生存時間呈正相關.
목적 탐토미소RNA(miR)-145재효질류중적표체급기여림상병리특정지간적관계,평고기재예측효질류환자예후중적개치.방법 검측96례효질류급26례정상뇌조직중miR-145적표체수평,용Kaplan-Meier법평고효질류환자루적생존솔화무진전생존솔.결과 miR-145재효질류중표체수평현저저우정상뇌조직(P＜0.01);miR-145적표체화효질류세계위생조직(WHO)분급、KPS평분、복발시간급생존시간현저상관(P＜0.05),이여환자년령、성별、종류부위、대소、종류절제범위、보조치료방식등무명현상관(P ＞0.05);miR-145고표체환자여저표체환자생존시간분별위(45.89±2.53)、(36.29±2.88)개월,차이유통계학의의(P＜0.05);miR-145저표체효질류환자사망풍험비(HR)위miR-145고표체효질류환자적2.023배(95％가신구간:1.107 ～3.695,P＜0.05).결론 miR-145재효질류중기도억제종류적작용.효질류중miR-145이상저표체,기표체수평여효질류환자생존시간정정상관.
Objective To investigate the relationship between the microRNA (miR)-145 expression and clinicopathologic factors in glioma tissue,and to evaluate the role of miR-145 in predicting prognosis of glioma patients.Methods We examined the miR-145 expression of 96 cases of glioma and 26 cases of normal brainformalin-fixed,paraffin-embedded (FFPE) tissues by reverse transcription polymerase chain reaction (RT-PCR).The cumulative survival and progression-free survival rate of glioma were assessed by Kaplan-Meier method.Results The low expression of miR-145 was correlated with World Health Organization (WHO) grade,Karnofsky performance score (KPS),time to recurrence,and survival (P ＜ 0.05),but there was no clear relationshib between the expression of miR-145 and age,gender,the extent of resection,tumor location,size,and adjuvant treatment (P＞ 0.05).The median survival time in the high miR-145 expression group [(45.89 ±2.53) months] was longer than that of the low miR-145 expression group [(36.29 ±2.88) months,P ＜0.05].The miR-145 appeared as significantly independent prognostic factors with a relative risk of 2.023 (95％ confidence interval,1.107-3.695) in Cox multivariate analysis.Conclusion Those results suggest that miR-145 may function as a tumor suppressor in glioma.Abnormal expression of miR-145 has been implicated in glioma.
