CAJ | 학술논문

目的探讨局部密网血流转向支架治疗兔侧壁型囊状动脉瘤的可行性.方法 10只家兔成功建立侧壁型动脉瘤9个,其中6个作为实验组置入局部密网血流转向支架,支架置入术后立即及术后28 d分别进行造影随访,并行病理学检查;另外3个动脉瘤作为对照组不置入支架,于建模成功后立即及术后28 d分别进行造影随访,并行病理学检查.结果实验组6个动脉瘤支架置入术后均即刻动脉瘤腔显影,造影剂在腔内滞留时间延长,流速变慢,未见涡流,载瘤动脉通畅无狭窄,支架位置准确;支架置入术后28 d动脉瘤腔闭塞,支架无移位,载瘤动脉通畅无狭窄;病理检查示支架置入术后28 d支架的内皮化基本完成,动脉瘤腔内均有血栓及纤维组织充填,支架嵌于载瘤动脉血管壁内,表面被新生内膜覆盖.而对照组兔3个动脉瘤无变化.结论局部密网血流转向支架治疗动脉瘤简单、安全、有效.
목적 탐토국부밀망혈류전향지가치료토측벽형낭상동맥류적가행성.방법 10지가토성공건립측벽형동맥류9개,기중6개작위실험조치입국부밀망혈류전향지가,지가치입술후립즉급술후28 d분별진행조영수방,병행병이학검사;령외3개동맥류작위대조조불치입지가,우건모성공후립즉급술후28 d분별진행조영수방,병행병이학검사.결과 실험조6개동맥류지가치입술후균즉각동맥류강현영,조영제재강내체류시간연장,류속변만,미견와류,재류동맥통창무협착,지가위치준학;지가치입술후28 d동맥류강폐새,지가무이위,재류동맥통창무협착;병리검사시지가치입술후28 d지가적내피화기본완성,동맥류강내균유혈전급섬유조직충전,지가감우재류동맥혈관벽내,표면피신생내막복개.이대조조토3개동맥류무변화.결론 국부밀망혈류전향지가치료동맥류간단、안전、유효.
Objective To assess the feasibility of flow-diverting stent in the treatment of lateral aneurysm models in common carotid artery of rabbits.Methods Ten rabbits were included in our study.Six of 9 successful experimental aneurysms were treated by flow-diverting stents,and the rest 3 aneurysms were untreated as controls.Angiography was performed immediately and 28 days after the procedure.Aneurysm and stented arteries were removed for histopathological examination.Results In experimental group,before stent placement the angiography of the common artery showed round saccular side-wall aneurysms and complex pattern of flow.Immediatrly after stent placement the aneurysms were still visble and the stented common carotid arteryies remained patent,but the time for the contrast agent in the aneurysm was longer,the complex pattern of flow disappeared.At 28th day after stent placement the aneurysms were no longer visble and the stented common carotid arteryies remained widely patent.All controlled aneurysms and common carotid arteries have been patent and unchanged for 28 days.Histological analysis indicated that all treated aneurismal pouches were almost filled with thrombus as well as fibrotic reactive scar tissue.Stent wires were found to be located within the vessel wall and encased by an extension of the tunica intima.The endothelium was almost mature at 28th day,and various degrees sof degenerative cells were seen under the transmission electron microscopy.Conclusion The occlusion of lateral aneurysm in common carotid artery of rabbits by flow-diverting stent is safe and effective.