中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
9期
1916-1918
,共3页
张新元%冯娟%秦海林%王在贵%刘征%范艳%别毕洲%祝源
張新元%馮娟%秦海林%王在貴%劉徵%範豔%彆畢洲%祝源
장신원%풍연%진해림%왕재귀%류정%범염%별필주%축원
白细胞介素%C反应蛋白%ω-6多聚不饱和脂肪酸%ω-3多聚不饱和脂肪酸
白細胞介素%C反應蛋白%ω-6多聚不飽和脂肪痠%ω-3多聚不飽和脂肪痠
백세포개소%C반응단백%ω-6다취불포화지방산%ω-3다취불포화지방산
Interleukin%C-reactive protein%ω-6 polyunsaturated fatty acid%ω-3 polyunsaturated fatty acid
目的 观察使用ω-6多聚不饱和脂肪酸(单药组)和ω-3联合ω-6多聚不饱和脂肪酸(联合组)对开颅血肿清除术患者白细胞介素(IL)及C反应蛋.白(CRP)的影响.方法 将21例开颅血肿清除术患者随机分为单药组(n=10)和联合组(n=11).观察两组术前、用药后第3天、用药后第7天IL、CRP、住院时间等指标.结果 用药后第3天,单药组IL-6[(318.5 ±51.7) mg/L]和CRP浓度[(93.1±33.6)mg/L]较术前IL-6[(338.9 ±44.6)mg/L]和CRP浓度[(123.7 ±37.2) mg/L]显著降低(P＜0.05),联合组IL-2[(650.1 ±59.3)mg/L,P＜0.01]、IL-6[(286.4±34.9)mg/L,P＜0.01]、IL-8[(306.4 ±44.8) mg/L,P＜0.01]、IL-10[(82.8±32.1)mg/L,P＜0.05]和CRP浓度[(89.2±37.1)mg/L,P＜0.01]较术前显著降低;使用后第7天,单药组IL-2[(635.1 ±70.3)mg/L,P＜0.01]、IL-6[(286.2 ±41.8) mg/L,P＜0.01]、IL-10[(158.6±51.1)mg/L,P＜0.05]和CRP浓度[(88.9±29.2) mg/L,P＜0.05]较术前显著降低,联合组中IL及CRP浓度进一步降低.结论 联合使用ω-3和ω-6多聚不饱和脂肪酸可提高患者治疗效果,促进患者术后恢复及改善患者预后.
目的 觀察使用ω-6多聚不飽和脂肪痠(單藥組)和ω-3聯閤ω-6多聚不飽和脂肪痠(聯閤組)對開顱血腫清除術患者白細胞介素(IL)及C反應蛋.白(CRP)的影響.方法 將21例開顱血腫清除術患者隨機分為單藥組(n=10)和聯閤組(n=11).觀察兩組術前、用藥後第3天、用藥後第7天IL、CRP、住院時間等指標.結果 用藥後第3天,單藥組IL-6[(318.5 ±51.7) mg/L]和CRP濃度[(93.1±33.6)mg/L]較術前IL-6[(338.9 ±44.6)mg/L]和CRP濃度[(123.7 ±37.2) mg/L]顯著降低(P＜0.05),聯閤組IL-2[(650.1 ±59.3)mg/L,P＜0.01]、IL-6[(286.4±34.9)mg/L,P＜0.01]、IL-8[(306.4 ±44.8) mg/L,P＜0.01]、IL-10[(82.8±32.1)mg/L,P＜0.05]和CRP濃度[(89.2±37.1)mg/L,P＜0.01]較術前顯著降低;使用後第7天,單藥組IL-2[(635.1 ±70.3)mg/L,P＜0.01]、IL-6[(286.2 ±41.8) mg/L,P＜0.01]、IL-10[(158.6±51.1)mg/L,P＜0.05]和CRP濃度[(88.9±29.2) mg/L,P＜0.05]較術前顯著降低,聯閤組中IL及CRP濃度進一步降低.結論 聯閤使用ω-3和ω-6多聚不飽和脂肪痠可提高患者治療效果,促進患者術後恢複及改善患者預後.
목적 관찰사용ω-6다취불포화지방산(단약조)화ω-3연합ω-6다취불포화지방산(연합조)대개로혈종청제술환자백세포개소(IL)급C반응단.백(CRP)적영향.방법 장21례개로혈종청제술환자수궤분위단약조(n=10)화연합조(n=11).관찰량조술전、용약후제3천、용약후제7천IL、CRP、주원시간등지표.결과 용약후제3천,단약조IL-6[(318.5 ±51.7) mg/L]화CRP농도[(93.1±33.6)mg/L]교술전IL-6[(338.9 ±44.6)mg/L]화CRP농도[(123.7 ±37.2) mg/L]현저강저(P＜0.05),연합조IL-2[(650.1 ±59.3)mg/L,P＜0.01]、IL-6[(286.4±34.9)mg/L,P＜0.01]、IL-8[(306.4 ±44.8) mg/L,P＜0.01]、IL-10[(82.8±32.1)mg/L,P＜0.05]화CRP농도[(89.2±37.1)mg/L,P＜0.01]교술전현저강저;사용후제7천,단약조IL-2[(635.1 ±70.3)mg/L,P＜0.01]、IL-6[(286.2 ±41.8) mg/L,P＜0.01]、IL-10[(158.6±51.1)mg/L,P＜0.05]화CRP농도[(88.9±29.2) mg/L,P＜0.05]교술전현저강저,연합조중IL급CRP농도진일보강저.결론 연합사용ω-3화ω-6다취불포화지방산가제고환자치료효과,촉진환자술후회복급개선환자예후.
Objective Comparing the effects of ω-6polyunsaturated fatty acid (Single group)and ω-3 combine ω-6 polyunsaturated fatty acid (Combine group) on interleukin (IL) and C-reactive protein (CRP) of patients with craniotomy evacuation of hematoma.Methods 21 patients were randomly assigned into Single group (n =10) and Combine croup (n =11).The index of IL and CRP of pre-operation,3 days and 7 days after administration drugs,and resident time was recorded detailed.Results After 3 days of administration drugs,concentrations of IL-6 [(318.5 ± 51.7) mg/L,P ＜ 0.01] and CRP [(93.1 ±33.6) mg/L,P ＜ 0.05] in single group andIL-2 [(650.1 ± 59.3) mg/L,P ＜ 0.01)],IL-6 [(286.4 ±34.9) mg/L,P＜0.01)],IL-8 [(306.4±44.8) mg/L,P＜0.01)],IL-10 [(82.8±32.1) mg/L,P ＜0.05] and CRP [(89.2 ± 37.1) mg/L,P ＜ 0.01)] in combine group were significantly lower than pre-operation,respectively.After 7 days of administration drugs,concentrations of IL-2 [(635.1 ±70.3) mg/L,P＜0.01)],IL-6 [(286.2 ±41.8) mg/L,P＜0.01)],IL-10 [(158.6 ±51.1) mg/L,P＜0.05)] and CRP [(88.9 ± 29.2) mg/L,P ＜ 0.05)] in single group were significantly lower than pre-operation,respectively.Concentrations of ILand CRP in combine group reducedmore than 3 days after administration drugs.Conclusion Combined use of ω-3 and ω-6 polyunsaturated fatty acid may play an important role in improving the effects of treatment,recovering and prognosis of patients.
