中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2013年
9期
665-669
,共5页
刘丽萍%张艳辉%范俊英%王彩丽
劉麗萍%張豔輝%範俊英%王綵麗
류려평%장염휘%범준영%왕채려
慢性肾脏病%高血压%MYH9%基因多态性
慢性腎髒病%高血壓%MYH9%基因多態性
만성신장병%고혈압%MYH9%기인다태성
Chronic kidney disease%Hypertension%MYH9%Gene polymorphism
目的 探讨慢性肾脏病(CKD)患者非肌性肌球蛋白重链9(MYH9)基因多态性与高血压易感性的相关性.方法 收集本院301例CKD患者临床资料,采用PCR法检测MYH9基因rs3752462、rs4821480两位点基因多态性,294名体检健康者作为健康对照组.分析不同MYH9基因型CKD患者的发病年龄、性别、收缩压、舒张压、原发病分布频率、服用降压药频率上的差异,以及rs3752462位点不同基因型与CKD患者高血压易感性的相关关系.结果 单因素分析结果显示,CT基因型患者的收缩压[(147.94±27.40) mm Hg]高于CC基因型[(136.43±19.09) mm Hg,P＜0.05]；CC基因型患者使用各种降压药的频率(7.4％)低于TT(43.9％)、CT(48.7％)基因型(P＜0.05)；校正年龄因素后,多因素Logistic回归分析结果显示,rs3752462位点CC基因型是CKD收缩压增高的保护因素,CT基因型CKD患者患高血压的概率是CC基因型的0.175倍.结论 携带MYH9基因rs3752462位点CC基因型的CKD患者相对不易患高血压,CC基因型是CKD患者收缩压增高的保护因素,等位基因C突变为T可导致收缩压升高.基因检测可作为CKD患者高血压发生率的预测因子之一.
目的 探討慢性腎髒病(CKD)患者非肌性肌毬蛋白重鏈9(MYH9)基因多態性與高血壓易感性的相關性.方法 收集本院301例CKD患者臨床資料,採用PCR法檢測MYH9基因rs3752462、rs4821480兩位點基因多態性,294名體檢健康者作為健康對照組.分析不同MYH9基因型CKD患者的髮病年齡、性彆、收縮壓、舒張壓、原髮病分佈頻率、服用降壓藥頻率上的差異,以及rs3752462位點不同基因型與CKD患者高血壓易感性的相關關繫.結果 單因素分析結果顯示,CT基因型患者的收縮壓[(147.94±27.40) mm Hg]高于CC基因型[(136.43±19.09) mm Hg,P＜0.05]；CC基因型患者使用各種降壓藥的頻率(7.4％)低于TT(43.9％)、CT(48.7％)基因型(P＜0.05)；校正年齡因素後,多因素Logistic迴歸分析結果顯示,rs3752462位點CC基因型是CKD收縮壓增高的保護因素,CT基因型CKD患者患高血壓的概率是CC基因型的0.175倍.結論 攜帶MYH9基因rs3752462位點CC基因型的CKD患者相對不易患高血壓,CC基因型是CKD患者收縮壓增高的保護因素,等位基因C突變為T可導緻收縮壓升高.基因檢測可作為CKD患者高血壓髮生率的預測因子之一.
목적 탐토만성신장병(CKD)환자비기성기구단백중련9(MYH9)기인다태성여고혈압역감성적상관성.방법 수집본원301례CKD환자림상자료,채용PCR법검측MYH9기인rs3752462、rs4821480량위점기인다태성,294명체검건강자작위건강대조조.분석불동MYH9기인형CKD환자적발병년령、성별、수축압、서장압、원발병분포빈솔、복용강압약빈솔상적차이,이급rs3752462위점불동기인형여CKD환자고혈압역감성적상관관계.결과 단인소분석결과현시,CT기인형환자적수축압[(147.94±27.40) mm Hg]고우CC기인형[(136.43±19.09) mm Hg,P＜0.05]；CC기인형환자사용각충강압약적빈솔(7.4％)저우TT(43.9％)、CT(48.7％)기인형(P＜0.05)；교정년령인소후,다인소Logistic회귀분석결과현시,rs3752462위점CC기인형시CKD수축압증고적보호인소,CT기인형CKD환자환고혈압적개솔시CC기인형적0.175배.결론 휴대MYH9기인rs3752462위점CC기인형적CKD환자상대불역환고혈압,CC기인형시CKD환자수축압증고적보호인소,등위기인C돌변위T가도치수축압승고.기인검측가작위CKD환자고혈압발생솔적예측인자지일.
Objective To explore the association between polymorphisms in non-muscle myosin heavy chain 9 gene (MYH9) and hypertension susceptibility in chronic kidney disease (CKD)patients.Methods Five hundred and ninety-five persons,including 301 patients with CKD and 294 healthy controls,were enrolled in the study.Two single nucleotide polymorphisms (SNPs) (rs3752462,rs4821480) were genotyped by TaqMan assay or a restriction fragment length polymorphism assay for a further case-control study.The discrepancies of the patients'quantitive traits (including age,sex,systolic and diastolic blood pressure,frequency of different primary diseases and using different kinds of antihypertensive drugs) among different genotypes of the two MYH9 SNPs were analyzed.Meanwhile,the association between polymorphisms in MYH9 and hypertension susceptibility in CKD patients were analyzed in the rs3752462 site.Results The systolic blood pressure of CT genotype patients [(147.94± 27.40) mm Hg] was significantly higher than that of C C genotype patients [(136.43 ± 19.09)mm Hg] by single factor analysis of variance (P ＜ 0.05).The frequency of using all kinds of antihypertensive drugs for CC genotype patients (7.4％) was lower than that of TT (43.9％) and CT (48.7％) genotype patients (P ＜ 0.05).After correcting the age factor,the result of Logistic regression analysis showed that CC genotype was a protective factor of systolic blood pressure increasing.The probability of high blood pressure for CT genotype patients with CKD was 0.175 times than that of CC genotype (95％ CI 0.071,0.431).Conclusions The CKD patients who carry the rs3752462 site CC genotype of MYH9 gene are not prone to high blood pressure.Polymorphism of MYH9 gene rs3752462 site is associated with systolic blood pressure in CKD patients.It may indicate that allele C mutation for T can lead to the increase in systolic blood pressure.
