中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2014年
2期
112-118
,共7页
石会兰%郑振峰%林珊%马慧%李峰坦%张敬%张云亭%于春水
石會蘭%鄭振峰%林珊%馬慧%李峰坦%張敬%張雲亭%于春水
석회란%정진봉%림산%마혜%리봉탄%장경%장운정%우춘수
肾皮质%肾髓质%磁共振成像%各向异性%弥散张量成像
腎皮質%腎髓質%磁共振成像%各嚮異性%瀰散張量成像
신피질%신수질%자공진성상%각향이성%미산장량성상
Kidney cortex%Kidney medulla%Magnetic resonance imaging%Anisotropy%Diffusion tensor imaging
目的 探索成人正常肾脏弥散张量磁共振成像(DTI-MRI)特点,以及与部分人体测量指标的相关性.方法 研究纳入80例行腹部磁共振检查的非肾脏病患者.DTI-MRI扫描采用单次激发自旋回波平面成像序列(SE-EPI)以及阵列空间敏感度编码技术(ASSET).测量双侧肾脏皮髓质平均弥散率(MD),轴向弥散率(AD),辐射弥散率(RD),第1、2、3特征向量值(λ1、λ2、λ3)和各向异性分数(FA).采集人体测量指标包括年龄、性别、身高、体质量、体质量指数(BMI)、体表面积(BSA)和估算的肾小球滤过率(eGFR).分析DTI参数与人体测量指标的相关性.结果 皮质区MD,λ2、λ3、RD值高于髓质区.皮质区FA值低于髓质区.左侧肾脏皮质区FA、λ1值和髓质区FA值高于右侧肾脏,左侧肾脏髓质λ3和RD值低于右侧肾脏.女性髓质区λ2、λ3和RD值高于男性而髓质FA值低于男性.髓质FA值(r=0.351,P=0.002)和λ1值(r=0.277,P=0.018)与eGFR正相关,而髓质FA值与年龄(r=-0.250,P=0.033)负相关.结论 肾脏水分子弥散特性在两侧肾脏和不同性别之间存在差异,髓质肾小管结构的规则性和小管内液弥散和灌注水平随年龄增加而改变.
目的 探索成人正常腎髒瀰散張量磁共振成像(DTI-MRI)特點,以及與部分人體測量指標的相關性.方法 研究納入80例行腹部磁共振檢查的非腎髒病患者.DTI-MRI掃描採用單次激髮自鏇迴波平麵成像序列(SE-EPI)以及陣列空間敏感度編碼技術(ASSET).測量雙側腎髒皮髓質平均瀰散率(MD),軸嚮瀰散率(AD),輻射瀰散率(RD),第1、2、3特徵嚮量值(λ1、λ2、λ3)和各嚮異性分數(FA).採集人體測量指標包括年齡、性彆、身高、體質量、體質量指數(BMI)、體錶麵積(BSA)和估算的腎小毬濾過率(eGFR).分析DTI參數與人體測量指標的相關性.結果 皮質區MD,λ2、λ3、RD值高于髓質區.皮質區FA值低于髓質區.左側腎髒皮質區FA、λ1值和髓質區FA值高于右側腎髒,左側腎髒髓質λ3和RD值低于右側腎髒.女性髓質區λ2、λ3和RD值高于男性而髓質FA值低于男性.髓質FA值(r=0.351,P=0.002)和λ1值(r=0.277,P=0.018)與eGFR正相關,而髓質FA值與年齡(r=-0.250,P=0.033)負相關.結論 腎髒水分子瀰散特性在兩側腎髒和不同性彆之間存在差異,髓質腎小管結構的規則性和小管內液瀰散和灌註水平隨年齡增加而改變.
목적 탐색성인정상신장미산장량자공진성상(DTI-MRI)특점,이급여부분인체측량지표적상관성.방법 연구납입80례행복부자공진검사적비신장병환자.DTI-MRI소묘채용단차격발자선회파평면성상서렬(SE-EPI)이급진렬공간민감도편마기술(ASSET).측량쌍측신장피수질평균미산솔(MD),축향미산솔(AD),복사미산솔(RD),제1、2、3특정향량치(λ1、λ2、λ3)화각향이성분수(FA).채집인체측량지표포괄년령、성별、신고、체질량、체질량지수(BMI)、체표면적(BSA)화고산적신소구려과솔(eGFR).분석DTI삼수여인체측량지표적상관성.결과 피질구MD,λ2、λ3、RD치고우수질구.피질구FA치저우수질구.좌측신장피질구FA、λ1치화수질구FA치고우우측신장,좌측신장수질λ3화RD치저우우측신장.녀성수질구λ2、λ3화RD치고우남성이수질FA치저우남성.수질FA치(r=0.351,P=0.002)화λ1치(r=0.277,P=0.018)여eGFR정상관,이수질FA치여년령(r=-0.250,P=0.033)부상관.결론 신장수분자미산특성재량측신장화불동성별지간존재차이,수질신소관결구적규칙성화소관내액미산화관주수평수년령증가이개변.
Objective To explore the characteristics of diffusion tensor imaging (DTI) magnetic resonance(MR) imaging in healthy native kidneys.Methods Eighty patients without chronic kidney disease underwent DTI-MRI with spin echo-echo planar (SE-EPI) sequences and array spatial sensitivity encoding technique (ASSET).Cortical and medullary mean diffusivity (MD),axial and radial diffusivity (AD and RD) values and primary,secondary and tertiary eigenvalues (λ1,λ2,λ3) and fractional anisotropy (FA) were analyzed in both kidneys and in different genders.Physiological indexes including age,gender,height,weight,body mass index (BMI),body surface area (BSA),and estimated glomerular filtration rate (eGFR) were recorded.Correlations between DTI parameters and physiological indexes were analyzed.Results Cortical MD,λ2,λ3,RD values were higher than corresponding medullary values except for λ1 value.Cortical FA value was lower than medullary FA value.Cortical FA,λ1 values and medullary FA were higher in left kidney than in right kidney.Medullary λ3 and RD values were lower in left kidney than in right kidney.Medullary λ2,λ3 and RD values were higher and medullary FA values were lower in female than in male.Medullary FA (r =0.351,P =0.002) and λ1 (r=0.277,P=0.018) positively correlated with eGFR and medullary FA (r=-0.250,P=0.033)negatively correlated with age.Conclusions Renal water molecular diffusion differences exist in human bilateral kidneys and different genders.Renal medullary tubular regularity,tubular diffusion and perfusion correlate with age.
