中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2014年
4期
254-261
,共8页
布海霞%程李涛%张爱华%汪涛%王悦%范敏华
佈海霞%程李濤%張愛華%汪濤%王悅%範敏華
포해하%정리도%장애화%왕도%왕열%범민화
高血压%血管僵硬%脉搏波分析%慢性肾脏病
高血壓%血管僵硬%脈搏波分析%慢性腎髒病
고혈압%혈관강경%맥박파분석%만성신장병
Hypertension%Vascular stiffness%Pulse wave analysis%Chronic kidney disease
目的 探讨在慢性肾脏病患者中,不同高血压亚型的大动脉僵硬度是否不同.方法 选取慢性肾脏病各期(CKD1～5期)患者626例患者,按高血压种类分为4个组:正常血压[收缩压(SBP)＜140 mmHg,舒张压(DBP)＜ 90 mmHg]、孤立性收缩期高血压[SBP≥140 mmHg,DBP＜ 90 mmHg]、孤立性舒张期高血压[SBP＜ 140 mmHg,DBP≥90 mmHg]和双期高血压[SBP≥140 mmHg,DBP≥90 mmHg].评估大动脉僵硬度的指标为脉压和脉搏波速度.结果 与其他组相比,孤立性舒张期高血压组平均年龄较低(P＜0.01).在孤立性收缩期高血压组糖尿病的百分比高于其他组.孤立性收缩期高血压组和双期高血压组大动脉僵硬度高于正常血压组和孤立性舒张期高血压组(P＜0.01),孤立性收缩期高血压组的大动脉僵硬度也高于双期高血压组,但在正常血压组和孤立性舒张期高血压组之间大动脉僵硬度差异无统计学意义.结论 不同高血压亚型的大动脉僵硬度明显不同,这可能是心血管疾病的病死率在不同高血压亚型中不同的潜在原因.
目的 探討在慢性腎髒病患者中,不同高血壓亞型的大動脈僵硬度是否不同.方法 選取慢性腎髒病各期(CKD1～5期)患者626例患者,按高血壓種類分為4箇組:正常血壓[收縮壓(SBP)＜140 mmHg,舒張壓(DBP)＜ 90 mmHg]、孤立性收縮期高血壓[SBP≥140 mmHg,DBP＜ 90 mmHg]、孤立性舒張期高血壓[SBP＜ 140 mmHg,DBP≥90 mmHg]和雙期高血壓[SBP≥140 mmHg,DBP≥90 mmHg].評估大動脈僵硬度的指標為脈壓和脈搏波速度.結果 與其他組相比,孤立性舒張期高血壓組平均年齡較低(P＜0.01).在孤立性收縮期高血壓組糖尿病的百分比高于其他組.孤立性收縮期高血壓組和雙期高血壓組大動脈僵硬度高于正常血壓組和孤立性舒張期高血壓組(P＜0.01),孤立性收縮期高血壓組的大動脈僵硬度也高于雙期高血壓組,但在正常血壓組和孤立性舒張期高血壓組之間大動脈僵硬度差異無統計學意義.結論 不同高血壓亞型的大動脈僵硬度明顯不同,這可能是心血管疾病的病死率在不同高血壓亞型中不同的潛在原因.
목적 탐토재만성신장병환자중,불동고혈압아형적대동맥강경도시부불동.방법 선취만성신장병각기(CKD1～5기)환자626례환자,안고혈압충류분위4개조:정상혈압[수축압(SBP)＜140 mmHg,서장압(DBP)＜ 90 mmHg]、고립성수축기고혈압[SBP≥140 mmHg,DBP＜ 90 mmHg]、고립성서장기고혈압[SBP＜ 140 mmHg,DBP≥90 mmHg]화쌍기고혈압[SBP≥140 mmHg,DBP≥90 mmHg].평고대동맥강경도적지표위맥압화맥박파속도.결과 여기타조상비,고립성서장기고혈압조평균년령교저(P＜0.01).재고립성수축기고혈압조당뇨병적백분비고우기타조.고립성수축기고혈압조화쌍기고혈압조대동맥강경도고우정상혈압조화고립성서장기고혈압조(P＜0.01),고립성수축기고혈압조적대동맥강경도야고우쌍기고혈압조,단재정상혈압조화고립성서장기고혈압조지간대동맥강경도차이무통계학의의.결론 불동고혈압아형적대동맥강경도명현불동,저가능시심혈관질병적병사솔재불동고혈압아형중불동적잠재원인.
Objective To investigate whether there is any difference in aortic stiffness among different hypertension subtypes in patients with chronic kidney disease.Methods Six hundred and twenty-six patients with chronic kidney disease were included in the present analysis.They were classified into four groups:normotension (n =391) with systolic blood pressure (SBP) ＜ 140 mmHg and diastolic blood pressure (DBP) ＜ 90 mmHg; isolated systolic hypertension (ISH,n =141) with SBP≥ 140mmHg and DBP ＜ 90 mmHg; isolated diastolic hypertension (IDH,n =25) with SBP ＜ 140 mmHg and DBP≥ 90 mmHg; systolic-diastolic hypertension (SDH,n =69) with SBP≥ 140 mmHg and DBP≥ 90mmHg.Aortic stiffness was assessed by pulse pressure and pulse wave velocity.Results The IDH group had lower mean age than the other groups(P ＜ 0.01).The percentage of diabetes in the ISH group was higher than that in the other groups.The comparison of aortic stiffness showed that the ISH and SDH groups had higher aortic stiffness than the normotension and IDH groups (P ＜ 0.01),but no significant difference in aortic stiffness was observed neither between the normotension and IDH groups nor between ISH and SDH groups.Conclusion Aortic stiffness is significantly different among different hypertension subtypes,which may be an underlying cause for the different cardiovascular mortality among the hypertension subtypes.
