中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2014年
6期
419-423
,共5页
周岩%邓永明%李川%龚运兵%毛志国%吴俊%李素芝%刘志红%唐政
週巖%鄧永明%李川%龔運兵%毛誌國%吳俊%李素芝%劉誌紅%唐政
주암%산영명%리천%공운병%모지국%오준%리소지%류지홍%당정
活组织检查,针吸%病理学,临床%高原
活組織檢查,針吸%病理學,臨床%高原
활조직검사,침흡%병이학,림상%고원
Biopsy,needle%Pathology,clinical%Plateaus
目的 探讨我国西藏高原地区与内地平原地区慢性肾脏病患者肾脏病理类型特点的差异.方法 采用回顾性对照研究,比较西藏高原地区80例与内地平原地区160例肾活检患者的一般情况及病理类型分布特点,以及病理与临床表现的关系.结果 (1)高原组与平原组男女比例存在明显差异(0.60∶1比1.11∶1,P＜0.01).(2)两组患者的病理类型分布存在明显差异,高原地区的原发性肾小球肾炎以微小病变为主(51.39％比14.53％,P＜0.01),而平原地区则以IgA肾病为主(49.57％比6.94％,P＜ 0.01),同时继发性肾小球肾炎中狼疮肾炎(LN)比例明显低于平原组(12.6％比34.9％,P＜0.05).结论 西藏高原地区最常见的临床表现是肾病综合征,最常见的原发性肾小球肾炎病理类型为微小病变,内地平原地区则以IgA肾病最为常见.西藏高原地区的继发性肾脏病以过敏性紫癜性肾炎为主,平原地区以LN为主.
目的 探討我國西藏高原地區與內地平原地區慢性腎髒病患者腎髒病理類型特點的差異.方法 採用迴顧性對照研究,比較西藏高原地區80例與內地平原地區160例腎活檢患者的一般情況及病理類型分佈特點,以及病理與臨床錶現的關繫.結果 (1)高原組與平原組男女比例存在明顯差異(0.60∶1比1.11∶1,P＜0.01).(2)兩組患者的病理類型分佈存在明顯差異,高原地區的原髮性腎小毬腎炎以微小病變為主(51.39％比14.53％,P＜0.01),而平原地區則以IgA腎病為主(49.57％比6.94％,P＜ 0.01),同時繼髮性腎小毬腎炎中狼瘡腎炎(LN)比例明顯低于平原組(12.6％比34.9％,P＜0.05).結論 西藏高原地區最常見的臨床錶現是腎病綜閤徵,最常見的原髮性腎小毬腎炎病理類型為微小病變,內地平原地區則以IgA腎病最為常見.西藏高原地區的繼髮性腎髒病以過敏性紫癜性腎炎為主,平原地區以LN為主.
목적 탐토아국서장고원지구여내지평원지구만성신장병환자신장병리류형특점적차이.방법 채용회고성대조연구,비교서장고원지구80례여내지평원지구160례신활검환자적일반정황급병리류형분포특점,이급병리여림상표현적관계.결과 (1)고원조여평원조남녀비례존재명현차이(0.60∶1비1.11∶1,P＜0.01).(2)량조환자적병리류형분포존재명현차이,고원지구적원발성신소구신염이미소병변위주(51.39％비14.53％,P＜0.01),이평원지구칙이IgA신병위주(49.57％비6.94％,P＜ 0.01),동시계발성신소구신염중랑창신염(LN)비례명현저우평원조(12.6％비34.9％,P＜0.05).결론 서장고원지구최상견적림상표현시신병종합정,최상견적원발성신소구신염병리류형위미소병변,내지평원지구칙이IgA신병최위상견.서장고원지구적계발성신장병이과민성자전성신염위주,평원지구이LN위주.
Objective To compare the characteristics of renal disease based on renal biopsy data between the Tibetan plateaus and the plain.Methods 160 chronic kidney diseases patients underwent renal biopsy from the plain and 80 cases from Tibet plateau were compared by parallel controlled manner.The relationship of renal pathology and clinical signs were also compared.Results (1) The male to female ratio was quite different between Tibet plateau and plain groups (0.60∶1 vs 1.11 ∶ 1,P ＜ 0.01).(2) The distribution of pathological types between two groups was quite different.The main reason of primary renal disease at Tibet plateau was minimal change disease (51.39％ vs 14.53％,P ＜ 0.01),but at plain it was IgA nephrology (49.57％ vs 6.94％,P ＜ 0.01).Meanwhile,the LN ratio in the secondary glomerulonephritis at the plateau region was significantly lower than those in the plain region (12.6％ vs 34.9％,P ＜ 0.05).Conclusions The most common reason of primary glomerular disease in plateau region is minimal change,and the most common clinical manifestation is nephrotic syndrome.IgA nephropathy in the plain is the most frequent primary renal disease.In terms of the secondary renal diseases,allergic purpura nephritis is dominated in the plateau region,whereas LN is frequently found in the plain.
