中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2014年
11期
805-812
,共8页
欧姆%梁孟君%张望%唐雪晴%陈崴%杨琼琼%毛海萍%余学清
歐姆%樑孟君%張望%唐雪晴%陳崴%楊瓊瓊%毛海萍%餘學清
구모%량맹군%장망%당설청%진외%양경경%모해평%여학청
狼疮肾炎%高尿酸血症%患病率%危险因素
狼瘡腎炎%高尿痠血癥%患病率%危險因素
랑창신염%고뇨산혈증%환병솔%위험인소
Lupus nephritis%Hyperuricemia%Prevalence%Risk factor
目的 了解本院狼疮肾炎(LN)患者高尿酸血症的患病率及其相关危险因素.方法 回顾性分析1998年1月至2010年12月于中山大学附属第一医院确诊为LN的959例患者的临床及病理特征.采用多因素Logistic回归分析LN患者高尿酸血症发生的影响因素.结果 本研究LN患者中,高尿酸血症的患病率为57.7％,其中CKD1～5期各期患者高尿酸血症的患病率分别为44.1％、65.7％、74.7％、77.6％、73.9％.LN患者伴发高尿酸血症的独立危险因素为血三酰甘油水平的升高及内皮细胞增生(≥50％);肾损害早期(CKD1～2期)LN患者伴发高尿酸血症的独立危险因素为血三酰甘油水平升高;肾损害中晚期(CKD3～5期)LN患者伴发高尿酸血症的独立危险因素为dsDNA阳性及抗心磷脂抗体IgM阳性.结论 本研究中LN患者高尿酸血症的患病率为57.7％,LN患者包括肾损害早期患者高尿酸血症发生与血三酰甘油密切相关,提示LN患者高尿酸血症的发生与代谢紊乱密切相关.
目的 瞭解本院狼瘡腎炎(LN)患者高尿痠血癥的患病率及其相關危險因素.方法 迴顧性分析1998年1月至2010年12月于中山大學附屬第一醫院確診為LN的959例患者的臨床及病理特徵.採用多因素Logistic迴歸分析LN患者高尿痠血癥髮生的影響因素.結果 本研究LN患者中,高尿痠血癥的患病率為57.7％,其中CKD1～5期各期患者高尿痠血癥的患病率分彆為44.1％、65.7％、74.7％、77.6％、73.9％.LN患者伴髮高尿痠血癥的獨立危險因素為血三酰甘油水平的升高及內皮細胞增生(≥50％);腎損害早期(CKD1～2期)LN患者伴髮高尿痠血癥的獨立危險因素為血三酰甘油水平升高;腎損害中晚期(CKD3～5期)LN患者伴髮高尿痠血癥的獨立危險因素為dsDNA暘性及抗心燐脂抗體IgM暘性.結論 本研究中LN患者高尿痠血癥的患病率為57.7％,LN患者包括腎損害早期患者高尿痠血癥髮生與血三酰甘油密切相關,提示LN患者高尿痠血癥的髮生與代謝紊亂密切相關.
목적 료해본원랑창신염(LN)환자고뇨산혈증적환병솔급기상관위험인소.방법 회고성분석1998년1월지2010년12월우중산대학부속제일의원학진위LN적959례환자적림상급병리특정.채용다인소Logistic회귀분석LN환자고뇨산혈증발생적영향인소.결과 본연구LN환자중,고뇨산혈증적환병솔위57.7％,기중CKD1～5기각기환자고뇨산혈증적환병솔분별위44.1％、65.7％、74.7％、77.6％、73.9％.LN환자반발고뇨산혈증적독립위험인소위혈삼선감유수평적승고급내피세포증생(≥50％);신손해조기(CKD1～2기)LN환자반발고뇨산혈증적독립위험인소위혈삼선감유수평승고;신손해중만기(CKD3～5기)LN환자반발고뇨산혈증적독립위험인소위dsDNA양성급항심린지항체IgM양성.결론 본연구중LN환자고뇨산혈증적환병솔위57.7％,LN환자포괄신손해조기환자고뇨산혈증발생여혈삼선감유밀절상관,제시LN환자고뇨산혈증적발생여대사문란밀절상관.
Objective To investigate the prevalence and related risk factors of hyperuricemia in patients with lupus nephritis (LN) in Southern China.Methods A single center retrospective study,959 adult LN patients diagnosed with biopsy-proven,who admitted to The First Affiliated Hospital,Sun Yat-sen University from 1998.01 to 2010.12 were recruited.Results Among this cohort,the prevalence of hyperuricemia was 57.7％.The prevalence of hyperuricemia for CKD stage 1,2,3,4,5 was 44.1％,65.7％,74.7％,77.6％,73.9％,respectively.Logistic regression analysis showed that increased serum triglyceride level and endothelial proliferation (≥50％) were independent risk factors of hyperuricemia in LN patients; Also,increased serum triglyceride level was an independent risk factor of hyperuricemia in LN patients of CKD stage 1-2; Positive dsDNA and positive anticardiolipin antibody were independent risk factors of hyperuricemia in LN patients of CKD stage 3-5.Conclusion The prevalence of hyperuricemia in LN patients from this cohort is 57.7％.Increased level of serum triglyceride is an independent risk factor associated with hyperuricemia in both overall LN patients and those of CKD stages 1-2.Therefore,the present study indicates that metabolic factors may influence each other,and should be paid more attention in the clinical practice of LN care.
