CAJ | 학술논문

报告1例儿童1型糖尿病合并肺毛霉病的临床表现及诊治情况,并复习文献,总结诊治经验.患儿为14岁女孩,新发1型糖尿病合并酮症酸中毒,并发毛霉菌肺炎.临床过程凶险、肺部病变快速进展,糖尿病控制差,入院2周起予两性霉素B脂质体治疗反应差,支气管灌洗无效,未及手术而于住院第51天大咯血死亡.复习文献,毛霉病多发生于血糖控制不良的2型成人糖尿病患者,儿童新发1型糖尿病并发毛霉菌肺炎少见.目前国际上推荐糖尿病合并肺毛霉病的治疗方案为:早期诊断,积极治疗原发病,尽早应用两性霉素B脂质体及尽早外科手术清创并切除受累的肺叶.
보고1례인동1형당뇨병합병폐모매병적림상표현급진치정황,병복습문헌,총결진치경험.환인위14세녀해,신발1형당뇨병합병동증산중독,병발모매균폐염.림상과정흉험、폐부병변쾌속진전,당뇨병공제차,입원2주기여량성매소B지질체치료반응차,지기관관세무효,미급수술이우주원제51천대각혈사망.복습문헌,모매병다발생우혈당공제불량적2형성인당뇨병환자,인동신발1형당뇨병병발모매균폐염소견.목전국제상추천당뇨병합병폐모매병적치료방안위:조기진단,적겁치료원발병,진조응용량성매소B지질체급진조외과수술청창병절제수루적폐협.
To analyze a rare case of pulmonary mucormycosis in a 14-year-old type 1 diabetes child and review the literatures of pulmonary mucormycosis in diabetes.The child was new onset type 1 diabetes and ketoacidosis combination with pulmonary mucormycosis.There was poor efficacy of treatment with amphotericin B liposome after admission 2 weeks and no effect of fibreoptic bronchoscopy.She died from severe haemoptysis due to no lung surgery.The literatures suggest that mucormycosis mostly occurs in poor glycemic control in adults with type 2 diabetes,rarely occurs in children new-onset type 1 diabetes.Current international recommendations on pulmonary mucormycosis diabetes requires early diagnosis,active treatment of primary disease,surgical debridement and liposomal amphotericin B.