中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2014年
4期
241-244
,共4页
赵然%常宝成%单春艳%杨菊红%徐延光%王颖%任惠珠%郑妙艳%王晓宇
趙然%常寶成%單春豔%楊菊紅%徐延光%王穎%任惠珠%鄭妙豔%王曉宇
조연%상보성%단춘염%양국홍%서연광%왕영%임혜주%정묘염%왕효우
糖尿病,2型%肾小球滤过率%胆红素
糖尿病,2型%腎小毬濾過率%膽紅素
당뇨병,2형%신소구려과솔%담홍소
Diabetes mellitus,type 2%Glomerular filtration rate%Bilirubin
目的 研究2型糖尿病患者预估肾小球滤过率(eGFR)与血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)的相关性.方法 选取2011年11月至2012年9月于天津医科大学代谢病医院糖尿病肾病科住院治疗的2型糖尿病患者523例为研究对象,按eGFR分为肾小球高滤过组(133例)、肾功能正常组(194例)、肾功能轻度下降组(125例)、肾功能中重度下降组(71例).比较各组TBIL、DBIL、IBIL水平,并行相关因素分析,多组计量资料间比较采用方差分析.结果 肾小球高滤过组各胆红素水平较肾功能正常组水平均明显下降[分别为TBIL:(10.9±4.0)比(12.5 ±4.5)μmol/L、DBIL:(3.8±1.6)比(4.4±1.7) μmol/L、IBIL:(7.1 ±2.8)比(8.0±3.1)μmol/L,均P＜0.05].肾功能中重度下降组TBIL、DBIL、IBIL水平较其他3组均明显下降(F=15.296、15.024、11.609,均P＜0.05).在eGFR＜ 130 ml/min的人群中,eGFR的相关分析结果提示:eGFR与年龄、病程、总胆固醇、低密度脂蛋白胆固醇呈负相关(r=-0.307、-0.203、-0.149、-0.111,均P＜0.05),与TBIL、DBIL、IBIL呈正相关(r=0.291、0.275、0.254,均P＜0.05).结论 2型糖尿病患者血清胆红素水平与肾小球滤过率相关.
目的 研究2型糖尿病患者預估腎小毬濾過率(eGFR)與血清總膽紅素(TBIL)、直接膽紅素(DBIL)、間接膽紅素(IBIL)的相關性.方法 選取2011年11月至2012年9月于天津醫科大學代謝病醫院糖尿病腎病科住院治療的2型糖尿病患者523例為研究對象,按eGFR分為腎小毬高濾過組(133例)、腎功能正常組(194例)、腎功能輕度下降組(125例)、腎功能中重度下降組(71例).比較各組TBIL、DBIL、IBIL水平,併行相關因素分析,多組計量資料間比較採用方差分析.結果 腎小毬高濾過組各膽紅素水平較腎功能正常組水平均明顯下降[分彆為TBIL:(10.9±4.0)比(12.5 ±4.5)μmol/L、DBIL:(3.8±1.6)比(4.4±1.7) μmol/L、IBIL:(7.1 ±2.8)比(8.0±3.1)μmol/L,均P＜0.05].腎功能中重度下降組TBIL、DBIL、IBIL水平較其他3組均明顯下降(F=15.296、15.024、11.609,均P＜0.05).在eGFR＜ 130 ml/min的人群中,eGFR的相關分析結果提示:eGFR與年齡、病程、總膽固醇、低密度脂蛋白膽固醇呈負相關(r=-0.307、-0.203、-0.149、-0.111,均P＜0.05),與TBIL、DBIL、IBIL呈正相關(r=0.291、0.275、0.254,均P＜0.05).結論 2型糖尿病患者血清膽紅素水平與腎小毬濾過率相關.
목적 연구2형당뇨병환자예고신소구려과솔(eGFR)여혈청총담홍소(TBIL)、직접담홍소(DBIL)、간접담홍소(IBIL)적상관성.방법 선취2011년11월지2012년9월우천진의과대학대사병의원당뇨병신병과주원치료적2형당뇨병환자523례위연구대상,안eGFR분위신소구고려과조(133례)、신공능정상조(194례)、신공능경도하강조(125례)、신공능중중도하강조(71례).비교각조TBIL、DBIL、IBIL수평,병행상관인소분석,다조계량자료간비교채용방차분석.결과 신소구고려과조각담홍소수평교신공능정상조수평균명현하강[분별위TBIL:(10.9±4.0)비(12.5 ±4.5)μmol/L、DBIL:(3.8±1.6)비(4.4±1.7) μmol/L、IBIL:(7.1 ±2.8)비(8.0±3.1)μmol/L,균P＜0.05].신공능중중도하강조TBIL、DBIL、IBIL수평교기타3조균명현하강(F=15.296、15.024、11.609,균P＜0.05).재eGFR＜ 130 ml/min적인군중,eGFR적상관분석결과제시:eGFR여년령、병정、총담고순、저밀도지단백담고순정부상관(r=-0.307、-0.203、-0.149、-0.111,균P＜0.05),여TBIL、DBIL、IBIL정정상관(r=0.291、0.275、0.254,균P＜0.05).결론 2형당뇨병환자혈청담홍소수평여신소구려과솔상관.
Objective To investigate the correlation between glomerular filtration rate (estimated glomerular filtration rate,eGFR) and serum total bilirubin (TBIL),direct bilirubin (DBIL),indirect bilirubin(IBIL) in patients with type 2 diabetes mellitus.Methods According to eGFR levcl,523 cases of type 2 diabetic inpatients from October 2011 to September 2012 in Department of Diabetic Nephropathy,Metabolic Diseases Hospital,Tianjin Medical University were divided into four groups:glomerular hyperfiltration group (n =133),normal renal function group (n =194),mild renal dysfunction group (n =125),moderate and severe renal dysfunction group (n =171).The differences of TBIL,DBIL and IBIL levels among the four groups were compared.The related factors analysis of eGFR was perfor,med.Variance analysis was used to analysize mulitiple groups of data.Results The bilirubin levels of glomerular hyperfiltration group was significantly lower than normal renal function group (P ＜ 0.05).TBIL level was (10.9 ±4.0) vs (12.5 ±4.5) μmol/L,DBIL level was (3.8 ± 1.6) vs (4.4 ± 1.7) μmol/L,IBIL level was (7.1 ± 2.8) vs (8.0 ± 3.1) μ mol/L.The levels of TBIL,DBIL and IBIL in moderate and severe renal dysfunction group significantly reduced than those of other three groups (F =15.296,15.024,11.609,all P＜ 0.05).In the patients with eGFR ＜ 130 ml/min,correlation analysis results indicate:eGFR was negatively correlated with age,the course of diabetes,total cholesterol,low-density lipoprotein cholesterol (r =-0.307,-0.203,-0.149,-0.111,all P ＜ 0.05),and was positively correlated with TBIL,DBIL and IBIL (r =0.291,0.275,0.254,all P ＜ 0.05).Conclusion Serum bilirubin levels are associated with glomerular filtration rate in patients with type 2 diabetes.
