CAJ | 학술논문

通过对1例42岁患有糖尿病合并先天性性征缺陷的女性患者进行系统的检查,了解Turner综合征的临床特征及其合并症,确定合适的治疗方案.该患者因口干、多饮、多尿12年,呕吐腹泻2d就诊.B超显示小子宫,双侧卵巢未见.糖化血红蛋白12.66％,口服葡萄糖耐量试验(OGTT)达到糖尿病诊断标准,同时C肽释放试验呈低平曲线.骨密度检查:腰椎骨质疏松,T值:-3.25,Z值:-3.01.外周血染色体核型分析示:45,X/46,XX.肾上腺皮质功能正常.确诊为Turner综合征(嵌合型)合并糖尿病及骨质疏松症.本研究表明当糖尿病合并先天性躯体发育异常时,临床医师应尽早注意全面检查,以便及早确诊Turner综合征并作相应治疗.
통과대1례42세환유당뇨병합병선천성성정결함적녀성환자진행계통적검사,료해Turner종합정적림상특정급기합병증,학정합괄적치료방안.해환자인구간、다음、다뇨12년,구토복사2d취진.B초현시소자궁,쌍측란소미견.당화혈홍단백12.66％,구복포도당내량시험(OGTT)체도당뇨병진단표준,동시C태석방시험정저평곡선.골밀도검사:요추골질소송,T치:-3.25,Z치:-3.01.외주혈염색체핵형분석시:45,X/46,XX.신상선피질공능정상.학진위Turner종합정(감합형)합병당뇨병급골질소송증.본연구표명당당뇨병합병선천성구체발육이상시,림상의사응진조주의전면검사,이편급조학진Turner종합정병작상응치료.
A 42 year old woman who complained of dry mouth,polydipsia for 12 years,vomiting and diarrhea for 2 days was clinically diagnosed as Turner syndrome.She was diagnosed as hypothyroidism 2 years ago.We completed systemic examinations for the patient.The type B ultrasound test of uterus and ovaries showed that her uterus was infantilism and the bilateral ovarian didn't imaging.The glycated hemoglobin(HbAlc) level was 12.66％,the results of oral glucose tolerance tests (OGTT) met the diagnostic criteria for diabetes mellitus.Bone mineral density:lumbar osteoporosis (T value:-3.25,Z value:-3.01).Chromosomal inspection showed a 45,X/46,XX karyotype.Adrenal cortex function was normal The patient was finally diagnosed as Turner syndrome(mosaictype type) and accompanied by diabetes,hypothyroidism and osteoporosis.This showed we should take a systematic inspection for a patient with diabetes and congenital defects sexuality in order to confirm the diagnosis of Turner syndrome and its complications as soon as possible,and to give an appropriate treatment.