中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2014年
9期
655-659
,共5页
糖尿病,2型%鸢尾素%胰岛素抵抗
糖尿病,2型%鳶尾素%胰島素牴抗
당뇨병,2형%연미소%이도소저항
Diabetes mellitus,type 2%Irisin%Insulin resistance
目的 探讨血清鸢尾素(irisin)水平与胰岛素抵抗是否存在相关性.方法 选取2013年6月至2014年1月在浙江大学医学院附属第一医院内分泌科2型糖尿病(T2DM)住院患者82例(男48例,女34例)为T2DM组,同期体检中心健康体检者62名(男33名,女29名)为对照组(NC组).所有受试者均接受体格检查、生化指标和血清irisin水平检测,T2DM组加测空腹胰岛素(FINS)、餐后血糖.采用Studentt检验、Pearson相关分析和多元线性回归进行统计学分析.结果 T2DM组血清irisin浓度明显低于NC组[(1.5±0.6)比(2.6±0.6)ng/L,t=-10.233,P＜0.05];且经Pearson相关分析,T2DM组血清irisin浓度与腰臀比(WHR)、餐后2h血糖、稳态模型胰岛素抵抗指数(HOMA-IR)呈负相关(r=-0.603、-0.295、-0.22,均P＜0.05);与病程、性别、年龄、是否吸烟、是否存在并发症、是否存在合并症、体质指数(BMI)、收缩压、舒张压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、FINS、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、动脉粥样硬化指数(AI)无明显相关性(均P＞0.05);进一步用多元线性回归分析发现,在排除性别、年龄、血压、并发症、合并症后,血清irisin水平与WHR呈显著负相关,WHR是血清irisin水平独立的负性影响因子(标准化回归系数=-3.995,P＜0.05).结论 T2DM患者血清irisin水平较正常人减低,并与胰岛素抵抗的发生发展有关.
目的 探討血清鳶尾素(irisin)水平與胰島素牴抗是否存在相關性.方法 選取2013年6月至2014年1月在浙江大學醫學院附屬第一醫院內分泌科2型糖尿病(T2DM)住院患者82例(男48例,女34例)為T2DM組,同期體檢中心健康體檢者62名(男33名,女29名)為對照組(NC組).所有受試者均接受體格檢查、生化指標和血清irisin水平檢測,T2DM組加測空腹胰島素(FINS)、餐後血糖.採用Studentt檢驗、Pearson相關分析和多元線性迴歸進行統計學分析.結果 T2DM組血清irisin濃度明顯低于NC組[(1.5±0.6)比(2.6±0.6)ng/L,t=-10.233,P＜0.05];且經Pearson相關分析,T2DM組血清irisin濃度與腰臀比(WHR)、餐後2h血糖、穩態模型胰島素牴抗指數(HOMA-IR)呈負相關(r=-0.603、-0.295、-0.22,均P＜0.05);與病程、性彆、年齡、是否吸煙、是否存在併髮癥、是否存在閤併癥、體質指數(BMI)、收縮壓、舒張壓、空腹血糖(FBG)、糖化血紅蛋白(HbA1c)、FINS、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、總膽固醇(TC)、甘油三酯(TG)、動脈粥樣硬化指數(AI)無明顯相關性(均P＞0.05);進一步用多元線性迴歸分析髮現,在排除性彆、年齡、血壓、併髮癥、閤併癥後,血清irisin水平與WHR呈顯著負相關,WHR是血清irisin水平獨立的負性影響因子(標準化迴歸繫數=-3.995,P＜0.05).結論 T2DM患者血清irisin水平較正常人減低,併與胰島素牴抗的髮生髮展有關.
목적 탐토혈청연미소(irisin)수평여이도소저항시부존재상관성.방법 선취2013년6월지2014년1월재절강대학의학원부속제일의원내분비과2형당뇨병(T2DM)주원환자82례(남48례,녀34례)위T2DM조,동기체검중심건강체검자62명(남33명,녀29명)위대조조(NC조).소유수시자균접수체격검사、생화지표화혈청irisin수평검측,T2DM조가측공복이도소(FINS)、찬후혈당.채용Studentt검험、Pearson상관분석화다원선성회귀진행통계학분석.결과 T2DM조혈청irisin농도명현저우NC조[(1.5±0.6)비(2.6±0.6)ng/L,t=-10.233,P＜0.05];차경Pearson상관분석,T2DM조혈청irisin농도여요둔비(WHR)、찬후2h혈당、은태모형이도소저항지수(HOMA-IR)정부상관(r=-0.603、-0.295、-0.22,균P＜0.05);여병정、성별、년령、시부흡연、시부존재병발증、시부존재합병증、체질지수(BMI)、수축압、서장압、공복혈당(FBG)、당화혈홍단백(HbA1c)、FINS、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、총담고순(TC)、감유삼지(TG)、동맥죽양경화지수(AI)무명현상관성(균P＞0.05);진일보용다원선성회귀분석발현,재배제성별、년령、혈압、병발증、합병증후,혈청irisin수평여WHR정현저부상관,WHR시혈청irisin수평독립적부성영향인자(표준화회귀계수=-3.995,P＜0.05).결론 T2DM환자혈청irisin수평교정상인감저,병여이도소저항적발생발전유관.
Objective To investigate the association between serum irisin and insulin resistance.Methods Eighty two subjects with type 2 diabetes mellitus(T2DM) were selected from in-patients in Department of Endocrinology,the First Affiliated Hospital,Zhejiang University School of Medicine (including 48 men and 34 women) as type 2 diabetes group,and 62 control subjects (NC) were selected from healthy people in medical centre (including 33 men and 29 women) as normal control group.Anthropometric indexes,metabolic parameters and serum irisin levels were measured in all subjects.Fasting insulin (FINS),postprandials blood glucose was measured in T2DM group.The data were analyzed using student-t test,Pearson correlation analysis and multiple linear regression analysis.Results Serum irisin levels were significantly decreased in T2D group compared with NC group((1.5 ±0.6)vs (2.6±0.6) ng/L,t=-10.233,P＜0.05).Pearson correlation analysis showed serum irisin levels in T2DM group were inversely associated with waist hip ratio (WHR),2 hour-postprandial blood glucose and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-0.603,-0.295,-0.22,P＜0.05).Other clinical parameters,including disease duration,gender,age,smoking habit,diabetic complications,other complications,body mass index (BMI),systolic blood pressure,diastolic blood pressure,fasting blood glucose (FBG),glycated hemoglobin A1c (HbA1c),FINS,high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),serum total cholesterol (TC),total triglycerides (TG) and atherosclerosis index (AI),were not correlated with irisin levels (P＞0.05 all above).Multiple linear regression analysis showed that after adjusting for gender,age,blood pressure,diabetic complications and other complications,WHR was significantly negatively associated with serum irisin levels,and WHR was the negative independent determinant of serum irisin (standardized regression coefficient =-3.995,P＜0.05).Conclusion Serum irisin levels are decreased in patients with T2DM and associated with the development of insulin resistance.
