CAJ | 학술논문

目的分析高频及低频重复经颅磁刺激(rTMS)分别对强直型及震颤型帕金森病(PD)的治疗作用及机理.方法 69例PD患者各分别接受高频(5Hz)及低频(0.5Hz) rTMS治疗,采用UPDRS评分、运动功能试验及运动诱发电位检查等分别评价疗效.结果 32例以强直为主要表现的PD患者经高频rTMS治疗后UPDRS总分较治疗前均显著降低(均P＜0.01),运动功能试验明显改善(P＜0.01),运动诱发电位静息阈值明显改善(P ＜0.01)；37例以震颤为主要表现的PD患者经低频rTMS治疗结束后UPDRS总分较治疗前均显著降低(均P＜0.01),运动功能试验明显改善(P＜0.01),运动诱发电位静息阈值明显改善(P＜0.01).结论高频rTMS对PD强直型效果优于震颤型,而低频rTMS对震PD颤型效果优于强直型.
목적 분석고빈급저빈중복경로자자격(rTMS)분별대강직형급진전형파금삼병(PD)적치료작용급궤리.방법 69례PD환자각분별접수고빈(5Hz)급저빈(0.5Hz) rTMS치료,채용UPDRS평분、운동공능시험급운동유발전위검사등분별평개료효.결과 32례이강직위주요표현적PD환자경고빈rTMS치료후UPDRS총분교치료전균현저강저(균P＜0.01),운동공능시험명현개선(P＜0.01),운동유발전위정식역치명현개선(P ＜0.01)；37례이진전위주요표현적PD환자경저빈rTMS치료결속후UPDRS총분교치료전균현저강저(균P＜0.01),운동공능시험명현개선(P＜0.01),운동유발전위정식역치명현개선(P＜0.01).결론 고빈rTMS대PD강직형효과우우진전형,이저빈rTMS대진PD전형효과우우강직형.
Objective To investigate the therapeutic effects of repeated transcranial magnetic stimulation (rTMS) at high and low frequency for the rigidity and tremors of Parkinson's disease (PD).Methods Sixty-nine patients with PD received rTMS at 5 Hz or 0.5 Hz.The efficacy was assessed using the unified Parkinson's disease rating scale (UPDRS),motor function tests and motor evoked potentials (MEPs).Results Thirty-two patients with rigidity from PD received 5 Hz rTMS therapy,and their UPDRS total scores decreased significantly.Their motor function test results improved significantly and their MEP relaxed motor thresholds were significantly elevated.Thirtyseven patients with tremors from PD received 0.5 Hz rTMS therapy,and their UPDRS total scores were significantly decreased.Their motor function test results improved significantly and their MEP relaxed motor thresholds were significantly elevated.Conclusion High frequency rTMS may improve the symptoms of patients with PD rigidity and low frequency rTMS may improve the symptoms of patients with PD tremors.