CAJ | 학술논문

目的系统观察阈下抑郁患者应用脑电生物反馈干预3周之后的转归,探索脑电生物反馈对阈下抑郁的干预效果.方法将符合纳入标准的60例患者按随机数字表法分为治疗组和对照组,每组30例.治疗组采用脑电生物反馈治疗仪进行干预治疗3周,每周治疗2次并评定1次；对照组不采用任何方法干预,观察3周,每周评定1次.连续观察3周和治疗后第6周随访,分别采用汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)和流行病学研究中心调查用抑郁量表(CES-D)对2组患者进行评分和分析,并以HAMD的减分率作为总体疗效标准.结果对阈下抑郁患者进行脑电生物反馈干预的治疗组疗效优于对照组,且差异有统计学意义(P＜0.01).治疗3周后,治疗组痊愈率、显效率和有效率分别为23.33％、70.00％和6.67％,而相应的对照组分别为0.00％、10.00％和16.67％.治疗后,治疗组SDS和CES-D的评分较治疗前均明显下降(P＜0.05),且与对照组同时间点组间比较,差异均有统计学意义(P＜0.05).结论脑电生物反馈能有效降低阈下抑郁患者的SDS、HAMD和CES-D评分；脑电生物反馈干预能有效改善患者的症状.
목적 계통관찰역하억욱환자응용뇌전생물반궤간예3주지후적전귀,탐색뇌전생물반궤대역하억욱적간예효과.방법 장부합납입표준적60례환자안수궤수자표법분위치료조화대조조,매조30례.치료조채용뇌전생물반궤치료의진행간예치료3주,매주치료2차병평정1차；대조조불채용임하방법간예,관찰3주,매주평정1차.련속관찰3주화치료후제6주수방,분별채용한밀이돈억욱량표(HAMD)、억욱자평량표(SDS)화류행병학연구중심조사용억욱량표(CES-D)대2조환자진행평분화분석,병이HAMD적감분솔작위총체료효표준.결과 대역하억욱환자진행뇌전생물반궤간예적치료조료효우우대조조,차차이유통계학의의(P＜0.01).치료3주후,치료조전유솔、현효솔화유효솔분별위23.33％、70.00％화6.67％,이상응적대조조분별위0.00％、10.00％화16.67％.치료후,치료조SDS화CES-D적평분교치료전균명현하강(P＜0.05),차여대조조동시간점조간비교,차이균유통계학의의(P＜0.05).결론 뇌전생물반궤능유효강저역하억욱환자적SDS、HAMD화CES-D평분；뇌전생물반궤간예능유효개선환자적증상.
Objective To explore the effect of electroencephalographic biofeedback (EEGBF) on subclinical depression by observing patients' outcome after 3 weeks of EEGBF intervention.Methods Sixty depressed patients were assigned to a treatment group and a control group using a random digits table,with 30 in each group.Patients in the treatment group received EEGBF twice weekly for 3 weeks and were evaluated once a week; patients in control group were not treated but were also evaluated weekly.The patients were observed for 3 weeks,then followed up 6 weeks after the treatment had ended.Scores on the Hamilton depression scale (HAMD),the self-rating depression scale (SDS) and the Center for Epidemiology survey (CES-D) were analyzed.Reduced HAMD score was regarded as the standard for evaluating the effectiveness of EEGBF.Results The effect in the treated group was significantly better than in the control group.After 3 weeks of treatment,the rate of cure was 23％,excellence was rated 70％ and effectiveness was 6.67％.The corresponding ratings for the control group were 0％,10％ and 17％ respectively.In treated group,SDS and CES-D scores were significantly lower than before treatment and significantly better than in the control group.Conclusion EEGBF can reduce patients' SDS,HAMD and CES-D scores and improve the signs of subclinical depression effectively.