CAJ | 학술논문

目的观察太极拳运动对稳定期慢性阻塞性肺疾病(COPD)患者血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)含量的影响.方法采用随机数字表法将74例稳定期COPD患者分为太极拳组及对照组.2组患者均给予对症支持治疗,太极拳组在此基础上辅以24式杨式太极拳训练,对照组仍按照往常习惯生活,未给予特殊训练干预.于入选时、干预6周及干预12周后分别抽取各组患者清晨空腹静脉血5 ml,对其血清中IL-6、IL-8及TNF-α浓度进行测定.结果对照组患者经干预6周及12周后,其血清中IL-6、IL-8及TNF-α浓度均较入选时无显著变化(P＞0.05);太极拳组患者经干预6周后,其血清中IL-6浓度[(248.86 ±64.18) pg/ml]较入选时无明显变化(P＞0.05),而IL-8浓度[(146.25±17.60) pg/ml]及TNF-α浓度[(57.03±12.19) pg/ml]均较入选时明显降低(P＜0.05);通过组间比较发现,2组患者上述指标组间差异均无统计学意义(P＞0.05);太极拳组患者经干预12周后,其血清中IL-6浓度[(220.89±62.25) pg/ml]、IL-8浓度[(138.28±24.86) pg/ml]及TNF-α浓度[(51.44 ±11.88)pg/ml]均较入选时进一步降低(P＜0.05),并且上述指标亦显著低于同期对照组水平(P＜0.05).结论太极拳锻炼能显著降低稳定期COPD患者血清中IL-6、IL-8及TNF-α浓度,推测太极拳锻炼改善COPD患者病情的作用机制可能与下调血清中IL-6、IL-8及TNF-α含量有关.
목적 관찰태겁권운동대은정기만성조새성폐질병(COPD)환자혈청중백세포개소-6(IL-6)、백세포개소-8(IL-8)급종류배사인자-α(TNF-α)함량적영향.방법 채용수궤수자표법장74례은정기COPD환자분위태겁권조급대조조.2조환자균급여대증지지치료,태겁권조재차기출상보이24식양식태겁권훈련,대조조잉안조왕상습관생활,미급여특수훈련간예.우입선시、간예6주급간예12주후분별추취각조환자청신공복정맥혈5 ml,대기혈청중IL-6、IL-8급TNF-α농도진행측정.결과 대조조환자경간예6주급12주후,기혈청중IL-6、IL-8급TNF-α농도균교입선시무현저변화(P＞0.05);태겁권조환자경간예6주후,기혈청중IL-6농도[(248.86 ±64.18) pg/ml]교입선시무명현변화(P＞0.05),이IL-8농도[(146.25±17.60) pg/ml]급TNF-α농도[(57.03±12.19) pg/ml]균교입선시명현강저(P＜0.05);통과조간비교발현,2조환자상술지표조간차이균무통계학의의(P＞0.05);태겁권조환자경간예12주후,기혈청중IL-6농도[(220.89±62.25) pg/ml]、IL-8농도[(138.28±24.86) pg/ml]급TNF-α농도[(51.44 ±11.88)pg/ml]균교입선시진일보강저(P＜0.05),병차상술지표역현저저우동기대조조수평(P＜0.05).결론 태겁권단련능현저강저은정기COPD환자혈청중IL-6、IL-8급TNF-α농도,추측태겁권단련개선COPD환자병정적작용궤제가능여하조혈청중IL-6、IL-8급TNF-α함량유관.
Objective To evaluate the effects of Taijiquan (TJQ) on serum concentration of interleukin-6 (IL-6) interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) in chronic obstructive pulmonary disease (COPD) in stationary stage.Methods Seventy-four patients with COPD at stationary stage were randomly divided into TJQ group,and control group,all patients received 12 weeks exercise.Subjects in TJQ group received 24 Yang's style TJQ program,while those in control group were instructed to maintain their usual activities and prescribed no any special exercise program.For each subject,data collection and comparative analysis of serum concentrations of IL-6,IL-8 and TNF-α were performed at baseline and at the 6th and 12th week.Results Serum concentrations of IL-6,IL-8 and TNF-α of control group at the 6th and 12th week showed no significant change compared with baseline(P ＞ 0.05) ; After 6 weeks of training,serum concentrations of IL-6 of TJQ group [(248.86 ± 64.18) ps/ml] showed no significant difference from baseline (P ＞ 0.05),serum concentrations of IL-8 [(146.25 ± 17.60)pg/ml] decreased (P ＜ 0.05),and TNF-α [(57.03 ± 12.19)pg/ml] decreased significantly compared with baseline (P ＜ 0.01).But compared with control group,the changes of three indexes were not statistically different (P ＞ 0.05).After 12 weeks of training,three indexes of TJQ group decreased significantly compared with baseline (P ＜ 0.01) ; compared with control group,serum concentrations of IL-6 [(220.89 ± 62.25) pg/ml] decreased and had statistical difference (P＜0.05),serum concentrations of IL-8 [(138.28 ± 24.86) pg/ml] and TNF-α[(51.44 ± 11.88)] also decreased compared with control group at the same period,and had significant difference (P ＜ 0.05).Conclusion TJQ exercise can decrease serum concentrations of IL-1,IL-6 and TNF-αin patients with COPD in stationary stage.It is speculated that the rehabilitation treatment mechanism of TJQ exercise on COPD may be associated with down-regulation of serum concentrations of IL-6,IL-8 and TNF-α.