中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2013年
8期
528-531
,共4页
闵晓红%王俊涛%袁静萍%李力
閔曉紅%王俊濤%袁靜萍%李力
민효홍%왕준도%원정평%리력
神经内分泌瘤%直肠肿瘤%直肠镜检查%肿瘤转移
神經內分泌瘤%直腸腫瘤%直腸鏡檢查%腫瘤轉移
신경내분비류%직장종류%직장경검사%종류전이
Neuroendocrine tumors%Rectal neoplasms%Proctoscopy%Neoplasm metastasis
目的 分析直肠神经内分泌肿瘤(NEN)的肠镜下特征和病理特征.方法 收集2005年1月至2012年5月66例直肠NEN患者的肠镜资料和病理资料,按照世界卫生组织胃肠胰腺NEN病理分类分级标准对其进行分类和分级,采用卡方检验和Fisher确切概率法分析神经内分泌瘤(NET)和神经内分泌癌(NEC)转移的相关因素.结果 66例直肠NEN分布于距肛门3～15 cm处.54例最大径≤1 cm,肠镜下多表现为黏膜下半球形息肉状隆起；9例最大径＞1～2 cm,其中5例表现为黏膜下局限性增厚或广基息肉状隆起；3例最大径＞2 cm,表现为菜花状或隆起型肿物致管腔环形狭窄.61例为NET(G1级),3例为NEC(G3级),2例混合性腺神经内分泌癌由NEC和腺癌两种成分组成.NET和NEC转移与患者性别无关(x2=0.158,P＞0.05),与年龄无关(Fisher确切概率法,P＞0.05),与肿瘤最大径有关(Fisher确切概率法,P＜0.05).结论 NEN是一组肠镜下特征和病理特征各异的肿瘤,NET和NEC转移似与患者性别和年龄无关,似与肿瘤最大径有关.
目的 分析直腸神經內分泌腫瘤(NEN)的腸鏡下特徵和病理特徵.方法 收集2005年1月至2012年5月66例直腸NEN患者的腸鏡資料和病理資料,按照世界衛生組織胃腸胰腺NEN病理分類分級標準對其進行分類和分級,採用卡方檢驗和Fisher確切概率法分析神經內分泌瘤(NET)和神經內分泌癌(NEC)轉移的相關因素.結果 66例直腸NEN分佈于距肛門3～15 cm處.54例最大徑≤1 cm,腸鏡下多錶現為黏膜下半毬形息肉狀隆起；9例最大徑＞1～2 cm,其中5例錶現為黏膜下跼限性增厚或廣基息肉狀隆起；3例最大徑＞2 cm,錶現為菜花狀或隆起型腫物緻管腔環形狹窄.61例為NET(G1級),3例為NEC(G3級),2例混閤性腺神經內分泌癌由NEC和腺癌兩種成分組成.NET和NEC轉移與患者性彆無關(x2=0.158,P＞0.05),與年齡無關(Fisher確切概率法,P＞0.05),與腫瘤最大徑有關(Fisher確切概率法,P＜0.05).結論 NEN是一組腸鏡下特徵和病理特徵各異的腫瘤,NET和NEC轉移似與患者性彆和年齡無關,似與腫瘤最大徑有關.
목적 분석직장신경내분비종류(NEN)적장경하특정화병리특정.방법 수집2005년1월지2012년5월66례직장NEN환자적장경자료화병리자료,안조세계위생조직위장이선NEN병리분류분급표준대기진행분류화분급,채용잡방검험화Fisher학절개솔법분석신경내분비류(NET)화신경내분비암(NEC)전이적상관인소.결과 66례직장NEN분포우거항문3～15 cm처.54례최대경≤1 cm,장경하다표현위점막하반구형식육상륭기；9례최대경＞1～2 cm,기중5례표현위점막하국한성증후혹엄기식육상륭기；3례최대경＞2 cm,표현위채화상혹륭기형종물치관강배형협착.61례위NET(G1급),3례위NEC(G3급),2례혼합성선신경내분비암유NEC화선암량충성분조성.NET화NEC전이여환자성별무관(x2=0.158,P＞0.05),여년령무관(Fisher학절개솔법,P＞0.05),여종류최대경유관(Fisher학절개솔법,P＜0.05).결론 NEN시일조장경하특정화병리특정각이적종류,NET화NEC전이사여환자성별화년령무관,사여종류최대경유관.
Objective To analyze the endoscopic and pathological characteristics of rectum neuroendocrine neoplasm (NEN).Methods From January 2005 to May 2012,the endoscopic and pathological data of 66 patients with rectum NEN were collected and graded according to historistic grade of gastroenteropancreatic-neuroendocrine neoplasm (GEP-NEN) by World Health Organization (WHO).The factors related with the metastasis of neuroendocrine tumor (NET) and neuroendocrine cancer (NEC) were analyzed by Chi square test and Fisher exact probability method.Results The locations of 66 NEN cases were between three and 15 cm from the anus.The diameters of 54 cases were less than 1 cm and under endoscopy the appearance of most tumors was submucosal hemispherical polypoid bulge.The diameters of nine cases were over 1 cm but less than 2 cm,of which the appearance of five cases was submucosal thickening or sessile polypoid bulge.The diameter of three cases was over 2 cm and the appearance was cauliflower-like or polypoid tumor which caused annular lumen stenosis.Sixty-one cases were NET (grade G1),three cases were NEC (grade G3) and two cases were mixed adenoendocrine carcinoma with both NEC and adenocarcinoma components.The metastasis of NET and NEC was not related with gender (x2 =0.158,P＞0.05) and age (Fisher exact probability method,P＞ 0.05),however was related with the diameter of tumor (Fisher exact probability method,P＜0.05).Conclusions NEN is a tumor with variety endoscopic characteristics and pathological features.The metastasis of NET and NEC seems not related with gender and age,but related with diameter.
