中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2014年
2期
118-120
,共3页
唐琪%周平%陈晓%王箫剑%毛高平%曹传平
唐琪%週平%陳曉%王簫劍%毛高平%曹傳平
당기%주평%진효%왕소검%모고평%조전평
Peutz-Jeghers综合征%肠套叠%内窥镜检查,胃肠道%小肠%肠息肉
Peutz-Jeghers綜閤徵%腸套疊%內窺鏡檢查,胃腸道%小腸%腸息肉
Peutz-Jeghers종합정%장투첩%내규경검사,위장도%소장%장식육
Peutz-Jeghers syndrome%Intussusception%Endoscopy,gastrointestinal%Intestine,small%Intestinal polyps
目的 分析Peutz-Jeghers综合征患者肠套叠的特点、危险度和始发因素.方法 选取2005年3月2日至2013年5月25日的Peutz-Jeghers综合征患者130例.采集患者临床资料,包括性别、年龄、Peutz-Jeghers综合征诊断年龄、家族史,以及肠套叠确诊年龄、临床表现、发生部位、治疗情况和导致肠套叠的息肉的最大径.以Kplan-Meier法分析肠套叠的累积危险度.结果 130例Peutz-Jeghers综合征患者中90例发生肠套叠,首次发生年龄为4～33岁,中位发生年龄为16岁.10、15、20、25、30岁时首次发生肠套叠的累积危险度分别为12.308％(16/130)、31.538％(41/130)、51.538％(67/130)、64.615％(84/130)、66.923％(87/130).男性与女性间、有家族史者和无家族史者间的肠套叠累积危险度差异均无统计学意义(P均＞0.05).90例患者共发生131次肠套叠,其中经手术、影像学检查、病史回顾确诊的分别有125、4、2次,初发症状为急腹症、腹痛呕吐的分别有111和15次,其余5次在常规检查中发现;115次发生于小肠,16次发生于结肠;予手术治疗、保守治疗、内镜下治疗(双气囊小肠镜下息肉切除术)的分别有127、3、1次.引起肠套叠的息肉最大径为15～70 mm,均数为40 mm.结论 Peutz-Jeghers综合征患者肠套叠发生年龄小,累积危险度高.肠套叠多由最大径≥15mm的息肉引起.
目的 分析Peutz-Jeghers綜閤徵患者腸套疊的特點、危險度和始髮因素.方法 選取2005年3月2日至2013年5月25日的Peutz-Jeghers綜閤徵患者130例.採集患者臨床資料,包括性彆、年齡、Peutz-Jeghers綜閤徵診斷年齡、傢族史,以及腸套疊確診年齡、臨床錶現、髮生部位、治療情況和導緻腸套疊的息肉的最大徑.以Kplan-Meier法分析腸套疊的纍積危險度.結果 130例Peutz-Jeghers綜閤徵患者中90例髮生腸套疊,首次髮生年齡為4～33歲,中位髮生年齡為16歲.10、15、20、25、30歲時首次髮生腸套疊的纍積危險度分彆為12.308％(16/130)、31.538％(41/130)、51.538％(67/130)、64.615％(84/130)、66.923％(87/130).男性與女性間、有傢族史者和無傢族史者間的腸套疊纍積危險度差異均無統計學意義(P均＞0.05).90例患者共髮生131次腸套疊,其中經手術、影像學檢查、病史迴顧確診的分彆有125、4、2次,初髮癥狀為急腹癥、腹痛嘔吐的分彆有111和15次,其餘5次在常規檢查中髮現;115次髮生于小腸,16次髮生于結腸;予手術治療、保守治療、內鏡下治療(雙氣囊小腸鏡下息肉切除術)的分彆有127、3、1次.引起腸套疊的息肉最大徑為15～70 mm,均數為40 mm.結論 Peutz-Jeghers綜閤徵患者腸套疊髮生年齡小,纍積危險度高.腸套疊多由最大徑≥15mm的息肉引起.
목적 분석Peutz-Jeghers종합정환자장투첩적특점、위험도화시발인소.방법 선취2005년3월2일지2013년5월25일적Peutz-Jeghers종합정환자130례.채집환자림상자료,포괄성별、년령、Peutz-Jeghers종합정진단년령、가족사,이급장투첩학진년령、림상표현、발생부위、치료정황화도치장투첩적식육적최대경.이Kplan-Meier법분석장투첩적루적위험도.결과 130례Peutz-Jeghers종합정환자중90례발생장투첩,수차발생년령위4～33세,중위발생년령위16세.10、15、20、25、30세시수차발생장투첩적루적위험도분별위12.308％(16/130)、31.538％(41/130)、51.538％(67/130)、64.615％(84/130)、66.923％(87/130).남성여녀성간、유가족사자화무가족사자간적장투첩루적위험도차이균무통계학의의(P균＞0.05).90례환자공발생131차장투첩,기중경수술、영상학검사、병사회고학진적분별유125、4、2차,초발증상위급복증、복통구토적분별유111화15차,기여5차재상규검사중발현;115차발생우소장,16차발생우결장;여수술치료、보수치료、내경하치료(쌍기낭소장경하식육절제술)적분별유127、3、1차.인기장투첩적식육최대경위15～70 mm,균수위40 mm.결론 Peutz-Jeghers종합정환자장투첩발생년령소,루적위험도고.장투첩다유최대경≥15mm적식육인기.
Objective To analyze the characteristics,risk and induced factors of intussusception in Peutz-Jeghers syndrome (PJS).Methods From March 2nd 2005 to May 25th 2013,a total of 130 patients with PJS were selected.The clinical data of patients were collected,which included gender,age,the diagnostic age of PJS,family history,the diagnostic age of intussusception,clinical features,location,treatment and the maximum diameter of polyps which caused intussusception.Kaplan-Meier was performed to analyze the cumulative risk of intussusception.Results Among 130 patients with PJS,90 cases had intussusception.The age when first time diagnosed was from four to 33,median age was 16.The cumulative risks of intussusception at 10,15,20,25 and 30 years were 12.308％ (16/130),31.538％(41/130),51.538％(67/130),64.615％(84/130) and 66.923％(87/130).There was no significant difference in the cumulative risk of intussusception between male and female; with family history and no family history (both P＞0.05).A total of 131 intussusception happened in 90 patients,of which diagnosed by surgery,imaging examination and history reviewer was 125,four and two times,respectively.The initial symptom of 111 times of intussusception was acute abdomen and 15 were abdominal pain and vomiting.The left five intussusception was found by regular:examination.One hundred and fifteen intussusception was in small intestine and 16 in colon.There was 127,three and one time treated with surgery,conservative treatment,endoscopic therapy (dual airbags intestinal endoscopic polypectomy),respectively.The maximum diameter of polyps which caused intussusception was from 15 to 70 mm,average 40 mm.Conclusions Intussusception of patients with PJS is at young age and with a high cumulative risk.Intussusception is generally caused by diameter over 15 mm polyps.
