CAJ | 학술논문

目的分析初发型广泛型UC的临床特征.方法回顾性分析新疆维吾尔自治区人民医院2007年5月至2013年3月确诊为初发型UC并住院治疗患者的病历资料,比较广泛型、直肠型及左半结肠型患者的民族构成比、性别比、诊断时年龄、居住环境、疾病严重程度、临床症状、实验室检查结果、结肠镜结果及病理组织学检查结果.三组间比较时,正态分布资料采用单因素方差分析,偏态分布资料及等级资料采用Kruskal-Wallis H检验,计数资料采用卡方检验.结果共纳入初发型广泛型UC患者67例,其中汉族、维吾尔族及哈萨克族分别为22例(32.8％)、39例(58.2％)、6例(9.0％),男女性别比为1.48∶1,诊断时的平均年龄为(43.27±16.91)岁,城市与农村患者比为3.19∶1,疾病严重程度以轻度多见,轻、中、重度分别为38例(56.7％)、14例(20.9％)、15例(22.4％).症状主要以腹痛、腹泻及黏液脓血便多见,部分患者可有发热及里急后重,少数患者伴有腹胀、恶心呕吐及外周关节炎.ESR加快、超敏CRP升高及血浆纤维蛋白原升高分别占37.3％(25/67)、44.8％(30/67)、31.3％(21/67).与初发型直肠型UC及初发型左半结肠型UC相比,初发型广泛型UC患者腹痛、腹泻、重度、维吾尔族多见及Mayo评分较高.且腹痛、腹泻、重度、维吾尔族及Mayo评分在三组间的两两比较中差异有统计学意义(P均＜0.017).结论新疆地区初发型广泛型UC以腹痛、腹泻及维吾尔族多见,Mayo评分较高,病变以轻中度为主,与直肠型及左半结肠型比较,重度明显增多.
목적 분석초발형엄범형UC적림상특정.방법 회고성분석신강유오이자치구인민의원2007년5월지2013년3월학진위초발형UC병주원치료환자적병력자료,비교엄범형、직장형급좌반결장형환자적민족구성비、성별비、진단시년령、거주배경、질병엄중정도、림상증상、실험실검사결과、결장경결과급병리조직학검사결과.삼조간비교시,정태분포자료채용단인소방차분석,편태분포자료급등급자료채용Kruskal-Wallis H검험,계수자료채용잡방검험.결과 공납입초발형엄범형UC환자67례,기중한족、유오이족급합살극족분별위22례(32.8％)、39례(58.2％)、6례(9.0％),남녀성별비위1.48∶1,진단시적평균년령위(43.27±16.91)세,성시여농촌환자비위3.19∶1,질병엄중정도이경도다견,경、중、중도분별위38례(56.7％)、14례(20.9％)、15례(22.4％).증상주요이복통、복사급점액농혈편다견,부분환자가유발열급리급후중,소수환자반유복창、악심구토급외주관절염.ESR가쾌、초민CRP승고급혈장섬유단백원승고분별점37.3％(25/67)、44.8％(30/67)、31.3％(21/67).여초발형직장형UC급초발형좌반결장형UC상비,초발형엄범형UC환자복통、복사、중도、유오이족다견급Mayo평분교고.차복통、복사、중도、유오이족급Mayo평분재삼조간적량량비교중차이유통계학의의(P균＜0.017).결론 신강지구초발형엄범형UC이복통、복사급유오이족다견,Mayo평분교고,병변이경중도위주,여직장형급좌반결장형비교,중도명현증다.
Objective To analyze the clinical characteristics of new onset diffuse type ulcerative colitis.Methods From May 2007 to March 2012,clinical data of hospitalized patients diagnosed in the People's Hospital of Xinjiang Autonomous Region as new onset ulcerative colitis were retrospectively analyzed,and constituent ratios of nationality,gender,age at diagnosis,residential environment,severity of disease,clinical symptoms,results of laboratory examination,results of colonoscopic examination and results of histopathological examination were compared among the diffuse type,the type of proctosigmoiditis and the type of left-sided colitis.Normal distribution data were analyzed by one-way analysis of variance,skew distribution data and ordinal data were analyzed by Kruskal-Wallis H test,and count data were analyzed by chi-square test in the comparison among the three groups.Results A total of 67 patients with new-onset diffuse type ulcerative colitis were enrolled.The constituent ratios of Han nationality,Uygur nationality and Kazak nationality were 32.8％(22/67),58.2％(39/67),and 9.0％(6/67),respectively.The ratio of male to female was 1.48∶ 1.The age at diagnosis was (43.27 ± 16.91) years old.The ratio of city to countryside was 3.19∶ 1.To the severity of the disease,mild was more common,the proportion of mild,moderate and severe were 56.7％(38/67),20.9％(14/67) and 22.4％ (15/67),respectively.Abdominal pain,diarrhea and purulent stools were the predominant symptoms.Some patients might have fever and tenesmus,a few patients accompanied with abdominal distension,nausea,vomiting and peripheral arthritis.The percentage of increasesed erythrocyte sedimentation rate,hypersensitive Creation protein and plasmatic fibrinogen was 37.3％(25/67),44.8％(30/67) and 31.3％ (21/67),respectively.To compare with patients with proctosigmoiditis and left-sided colitis,the patients with new-onset diffuse type colitis had higher Mayo score and were more prone to develop abdominal pain,diarrhea,severe colitis,and were more common in Uygur nationality.There were statistical differences in abdominal pain,diarrhea,severity,ratio of Uygur nationality and Mayo score in pairwise comparison among the three groups (all P＜0.017).Conclusion Abdominal pain,diarrhea and Uygur nationality are more common in new onset diffuse ulcerative colitis in Xinjiang Region,with relatively high Mayo score and mild to moderate degree,while severity significantly increased compared to the type of proctosigmoiditis and the type of left-sided colitis.