中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
9期
795-799
,共5页
叶雯婧%郑铃%王征桦%陈欢欢
葉雯婧%鄭鈴%王徵樺%陳歡歡
협문청%정령%왕정화%진환환
高血压%多态性,单核苷酸%荟萃分析
高血壓%多態性,單覈苷痠%薈萃分析
고혈압%다태성,단핵감산%회췌분석
Hypertension%Polymorphism,single nucleotide%meta-analysis
目的 荟萃分析评价CYP11B2-344C/T多态性与中国汉族原发性高血压易感及血压水平的关联.方法 检索相关数据库,收集国内外研究CYP11 B2-344C/T多态性与中国汉族原发性高血压关联的文献,依据NEWCASTLE-OTTAWA病例对照研究质量评定量表(NOS)评价文献质量,应用Stata选择最佳遗传模型,分析异质性和计算合并OR、收缩压和舒张压的标准化均数差(SMD)值及95％ CI.结果研究对象共计9249例,原发性高血压与对照组CC比TT、CT比TT、CC比CT的OR(95％ CI)值依次为1.022(95％ CI:0.879 ～1.190)、1.108 (95％ CI:0.951 ～1.291)、1.050(95％ CI:0.995～1.109)；收缩压(共显性模型)CC比TT的SMD值及95％ CI为0.315 (0.066～0.565),Z=2.48,P=0.013,CT比TT的SMD值及95％ CI为0.088(0.014 ～0.162),Z=2.24,P=0.019.结论 C等位基因的携带可使中国汉族人群收缩压上升,尚无证据证明CYP11B2(-344C/T)多态性与中国汉族原发性高血压易感有关联.
目的 薈萃分析評價CYP11B2-344C/T多態性與中國漢族原髮性高血壓易感及血壓水平的關聯.方法 檢索相關數據庫,收集國內外研究CYP11 B2-344C/T多態性與中國漢族原髮性高血壓關聯的文獻,依據NEWCASTLE-OTTAWA病例對照研究質量評定量錶(NOS)評價文獻質量,應用Stata選擇最佳遺傳模型,分析異質性和計算閤併OR、收縮壓和舒張壓的標準化均數差(SMD)值及95％ CI.結果研究對象共計9249例,原髮性高血壓與對照組CC比TT、CT比TT、CC比CT的OR(95％ CI)值依次為1.022(95％ CI:0.879 ～1.190)、1.108 (95％ CI:0.951 ～1.291)、1.050(95％ CI:0.995～1.109)；收縮壓(共顯性模型)CC比TT的SMD值及95％ CI為0.315 (0.066～0.565),Z=2.48,P=0.013,CT比TT的SMD值及95％ CI為0.088(0.014 ～0.162),Z=2.24,P=0.019.結論 C等位基因的攜帶可使中國漢族人群收縮壓上升,尚無證據證明CYP11B2(-344C/T)多態性與中國漢族原髮性高血壓易感有關聯.
목적 회췌분석평개CYP11B2-344C/T다태성여중국한족원발성고혈압역감급혈압수평적관련.방법 검색상관수거고,수집국내외연구CYP11 B2-344C/T다태성여중국한족원발성고혈압관련적문헌,의거NEWCASTLE-OTTAWA병례대조연구질량평정량표(NOS)평개문헌질량,응용Stata선택최가유전모형,분석이질성화계산합병OR、수축압화서장압적표준화균수차(SMD)치급95％ CI.결과연구대상공계9249례,원발성고혈압여대조조CC비TT、CT비TT、CC비CT적OR(95％ CI)치의차위1.022(95％ CI:0.879 ～1.190)、1.108 (95％ CI:0.951 ～1.291)、1.050(95％ CI:0.995～1.109)；수축압(공현성모형)CC비TT적SMD치급95％ CI위0.315 (0.066～0.565),Z=2.48,P=0.013,CT비TT적SMD치급95％ CI위0.088(0.014 ～0.162),Z=2.24,P=0.019.결론 C등위기인적휴대가사중국한족인군수축압상승,상무증거증명CYP11B2(-344C/T)다태성여중국한족원발성고혈압역감유관련.
Objective To explore the association between CYP11B2 gene polymorphism and essential hypertension,blood pressure level in Chinese Han population by meta-analysis.Methods After searching database,the research quality was quantified according to NOS.Genetic model,heterogeneity,publication bias,overall OR/standardized mean difference (SMD) and 95％ CI were explored by Stata,19 studies including 9249 subjects were included in this meta-analysis.Results Compared to control group,0R(95％ CI) of CC vs.TT,CT vs.TT,CC vs.CT in essential hypertensive patients were 1.022(95％ CI:0.879-1.190),1.108 (95％ CI:0.951-1.291),1.050(95％ CI:0.995-1.109),respectively; SMD (95％CI) was 0.315 (0.066-0.565,P ＜ 0.05) for systolic pressure derived CC vs.TT,and 0.088 (0.014-0.162,P ＜ 0.05) for CT vs.TT.Conclusion Individuals with-344C CYP11 B2 allele are at higher risk of increased systolic blood pressure,but there is no evidence showing association between CYP11 B2 polymorphism and susceptibility of essential hypertension in Chinese Han population.
