CAJ | 학술논문

目的调查福建沿海某地区正常高值血压和高血压人群心血管危险因素和全身血管损伤情况.方法横断面调查福建沿海某地区30岁以上人群3344例,行糖脂、尿酸、尿微量蛋白、肱踝脉搏波速度(baPWV)和视网膜中央动脉直径(CRAE)等检测,采用方差分析和logistic回归分析正常高值血压和高血压人群危险因素及血管损伤情况.结果 (1)调查地区年龄标化后正常高值血压人群占总调查人群比例和年龄标化后高血压的患病率均为30.0％；高血压人群65.5％ (909/1388)合并3种及以上心血管危险因素,正常高值血压人群37.5％(330/880)合并3种及以上心血管危险因素.(2)高血压和正常高值血压人群UACR、baPWV、CRAE异常发生率分别为25.7％ (357/1388)、84.2％ (1169/1388)、29.5％ (409/1388)和20.0％ (176/880)、29.1％ (256/880)、25.6％(225/880),较正常血压人群异常发率生8.5％(91/1076)、8.9％(96/1076)、18.8％(202/1076)均明显升高(P均＜0.05).(3)logistic回归示正常高值血压和高血压是UACR、baPWV、CRAE的独立相关因素,正常高值的OR值和95％可信区间分别为1.496(1.095 ～2.044)、2.477(1.815～3.381)、0.700(0.549 ～0.891),高血压的OR值和95％可信区间分别为1.976(1.454～2.686)、17.707(12.938～24.235)、0.591 (0.474 ～0.736).结论福建省沿海地区正常高值血压和高血压人群合并多种心血管危险因素,正常高值血压和高血压血管损伤风险较正常血压人群明显升高.
목적 조사복건연해모지구정상고치혈압화고혈압인군심혈관위험인소화전신혈관손상정황.방법 횡단면조사복건연해모지구30세이상인군3344례,행당지、뇨산、뇨미량단백、굉과맥박파속도(baPWV)화시망막중앙동맥직경(CRAE)등검측,채용방차분석화logistic회귀분석정상고치혈압화고혈압인군위험인소급혈관손상정황.결과 (1)조사지구년령표화후정상고치혈압인군점총조사인군비례화년령표화후고혈압적환병솔균위30.0％；고혈압인군65.5％ (909/1388)합병3충급이상심혈관위험인소,정상고치혈압인군37.5％(330/880)합병3충급이상심혈관위험인소.(2)고혈압화정상고치혈압인군UACR、baPWV、CRAE이상발생솔분별위25.7％ (357/1388)、84.2％ (1169/1388)、29.5％ (409/1388)화20.0％ (176/880)、29.1％ (256/880)、25.6％(225/880),교정상혈압인군이상발솔생8.5％(91/1076)、8.9％(96/1076)、18.8％(202/1076)균명현승고(P균＜0.05).(3)logistic회귀시정상고치혈압화고혈압시UACR、baPWV、CRAE적독립상관인소,정상고치적OR치화95％가신구간분별위1.496(1.095 ～2.044)、2.477(1.815～3.381)、0.700(0.549 ～0.891),고혈압적OR치화95％가신구간분별위1.976(1.454～2.686)、17.707(12.938～24.235)、0.591 (0.474 ～0.736).결론 복건성연해지구정상고치혈압화고혈압인군합병다충심혈관위험인소,정상고치혈압화고혈압혈관손상풍험교정상혈압인군명현승고.
Objective To observe the cardiovascular risk factors and vascular damage status of preand hypertentsive population in the coastal areas of Fujian province.Methods This cross-sectional study surved 3344 Fujian coastal people aged older than 30 years.Glycolipids,uric acid,urine,microalbumin,brachial-ankle pulse wave velocity (baPWV) and central retinal arteriolar equivalent(CRAE) measurements were performed.Variance analysis and binary logistic regression were applied to evaluate cardiovascular risk factors and vascular damage of prehypertensive as well as hypertensive population.Results (1) The morbidity of prehypertension as well as hypertension was 30.0％ in coastal population of Fujian Province,there were more than 3 cardiovascular risk factors in 65.5％ (909/1388) of the hypertensive population and 37.5％ of the prehypertensive population.(2) The abnormal rates of creatinine ratio(UACR),baPWV,and CRAE in hypertensive [25.7％ (357/1388),84.2％ (1169/1388),29.5％ (409/1388)] and prehypertensive population [20.0％ (176/880),29.1％ (256/880),25.6％ (225/880)] were significantly higher than those of normotensive individuals [8.5％ (91/1076),8.9％ (96/1076),18.8％(202/1076),all P ＜ 0.05].(3) Prehypertension and hypertension served as independent risk factors of UACR,baPWV and CRAE according to logistic regression analysis.The odds ratios (OR) value and 95％ confidence intervals were 1.496 (1.095-2.044),2.477 (1.815-3.381),0.700 (0.549-0.891) in prehypertensive population,and 1.976 (1.454-2.686),7.707 (12.938-24.235),0.591 (0.474-0.736) in hypertensive population.Conclusion Multiple cardiovascular risk factors coexist in prehypertensive and hypertensive population in the coastal area of coster areas of Fujian province and there is more morbidity of vascular damage in prehypertensive and hypertensive individuals compared to normotensive subiects in these areas.