中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2013年
11期
916-921
,共6页
毛婷%苗海军%许国军%甘天翊%周贤惠%张健%李发鹏%汤宝鹏
毛婷%苗海軍%許國軍%甘天翊%週賢惠%張健%李髮鵬%湯寶鵬
모정%묘해군%허국군%감천익%주현혜%장건%리발붕%탕보붕
心房颤动%多态性,单核苷酸%维吾尔族%汉族
心房顫動%多態性,單覈苷痠%維吾爾族%漢族
심방전동%다태성,단핵감산%유오이족%한족
Atrial fibrillation%Polymorphism,single nucleotide%Uygur nationlity%Han nationlity
目的 探讨新疆地区维吾尔族及汉族人群心房颤动(房颤)患者与KCNE1 G38S及KCNE4 E145D的关系.方法 收集新疆地区房颤患者维吾尔族组237例及汉族组251例,按年龄和性别1∶1比例配对,选取维吾尔族对照237例及汉族对照251例,采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)鉴定KCNE1 G38S及KCNE4 E145D基因型及等位基因分布.结果 KCNE1 G38S基因型及等位基因频率分布在汉族人群中未证实与房颤有关(P =0.556,P=0.946),多因素logistic回归分析显示仍无统计学差异(P=0.698);在维吾尔族人群中有统计学意义(P=0.018,P=0.003),多因素logistic回归分析,KCNE1 38G是维吾尔族房颤的独立危险因素之一(OR=1.634,95％ CI:1.192 ～2.240,P=0.002).KCNE4 E145D基因型及等位基因频率分布在维吾尔族及汉族人群中均有统计学意义(P =0.041,P=0.015; P=0.032,P=0.013),多因素logistic回归分析显示,KCNE4 145D在两人群中均是房颤患者的危险因素之一(OR=1.636,95％CI:1.173～2.281,P=0.004;OR=1.491,95％CI:1.076 ～2.065,P=0.016).结论 在新疆地区汉族人群中,KCNE1 G38S多态性与房颤无相关性;在维族人群中,KCNE1 G38S与房颤相关.在维吾尔族人群及汉族人群中,KCNF4 E145D与房颤相关.
目的 探討新疆地區維吾爾族及漢族人群心房顫動(房顫)患者與KCNE1 G38S及KCNE4 E145D的關繫.方法 收集新疆地區房顫患者維吾爾族組237例及漢族組251例,按年齡和性彆1∶1比例配對,選取維吾爾族對照237例及漢族對照251例,採用聚閤酶鏈反應-限製性內切酶片段長度多態性(PCR-RFLP)鑒定KCNE1 G38S及KCNE4 E145D基因型及等位基因分佈.結果 KCNE1 G38S基因型及等位基因頻率分佈在漢族人群中未證實與房顫有關(P =0.556,P=0.946),多因素logistic迴歸分析顯示仍無統計學差異(P=0.698);在維吾爾族人群中有統計學意義(P=0.018,P=0.003),多因素logistic迴歸分析,KCNE1 38G是維吾爾族房顫的獨立危險因素之一(OR=1.634,95％ CI:1.192 ～2.240,P=0.002).KCNE4 E145D基因型及等位基因頻率分佈在維吾爾族及漢族人群中均有統計學意義(P =0.041,P=0.015; P=0.032,P=0.013),多因素logistic迴歸分析顯示,KCNE4 145D在兩人群中均是房顫患者的危險因素之一(OR=1.636,95％CI:1.173～2.281,P=0.004;OR=1.491,95％CI:1.076 ～2.065,P=0.016).結論 在新疆地區漢族人群中,KCNE1 G38S多態性與房顫無相關性;在維族人群中,KCNE1 G38S與房顫相關.在維吾爾族人群及漢族人群中,KCNF4 E145D與房顫相關.
목적 탐토신강지구유오이족급한족인군심방전동(방전)환자여KCNE1 G38S급KCNE4 E145D적관계.방법 수집신강지구방전환자유오이족조237례급한족조251례,안년령화성별1∶1비례배대,선취유오이족대조237례급한족대조251례,채용취합매련반응-한제성내절매편단장도다태성(PCR-RFLP)감정KCNE1 G38S급KCNE4 E145D기인형급등위기인분포.결과 KCNE1 G38S기인형급등위기인빈솔분포재한족인군중미증실여방전유관(P =0.556,P=0.946),다인소logistic회귀분석현시잉무통계학차이(P=0.698);재유오이족인군중유통계학의의(P=0.018,P=0.003),다인소logistic회귀분석,KCNE1 38G시유오이족방전적독립위험인소지일(OR=1.634,95％ CI:1.192 ～2.240,P=0.002).KCNE4 E145D기인형급등위기인빈솔분포재유오이족급한족인군중균유통계학의의(P =0.041,P=0.015; P=0.032,P=0.013),다인소logistic회귀분석현시,KCNE4 145D재량인군중균시방전환자적위험인소지일(OR=1.636,95％CI:1.173～2.281,P=0.004;OR=1.491,95％CI:1.076 ～2.065,P=0.016).결론 재신강지구한족인군중,KCNE1 G38S다태성여방전무상관성;재유족인군중,KCNE1 G38S여방전상관.재유오이족인군급한족인군중,KCNF4 E145D여방전상관.
Objective To investigate the association between the KCNE1 gene G38S and the KCNE4 gene E145D and atrial fibrillation in Uygur and Han populations living in Xinjiang.Methods KCNE1 gene G38S and the KCNE4 gene E145D genotype and frequency were determined using PCR restriction fragment length polymorphism (PCR-RFLP) in 488 atrial fibrillation patients (237 Uygur and 251 Han residents) and 488 age-and-gender matched controls (237 Uygur and 251 Han residents).Results Genotype and allele frequency of KCNE1 gene G38S were similar between atrial fibrillation group and control group in the Han population (P =0.556,P =0.946).In the Uygur population,there was a statistical difference between atrial fibrillation group and control group (P =0.018,P =0.003).Logistic regression analysis revealed the KCNE1 38 G was one of the independent risk factors for atrial fibrillation in the Uygur population (OR =1.634,95％ CI:1.192-2.240,P =0.002).The KCNE4 gene E145D,genotype and allele frequency were significantly different between atrial fibrillation group and control group in the Uygur population and Han population(P =0.041,P =0.015 ;P =0.032,P =0.013).Logistic regression analysis revealed the KCNE4 145D was one of the independent risk factors for atrial fibrillation in the Uygur population and Han population (OR =1.636,95％ CI:1.173-2.281,P =0.004; OR =1.491,95％ CI:1.076-2.065,P =0.016).Conclusions KCNE1 G38S is not associated with atrial fibrillation in the Han population while the KCNE1 G38S is associated with atrial fibrillation in the Uygur population.KCNE4 gene E145D is associated with atrial fibrillation in both Uygur population and Han population.
